PN placement:Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|JAMM / MPN / ubiquitin binding (row 1) and ...|Ubiquitin and UBL binding|DNA repair|BRISC complex component|... (row 2) ; PN-node mapping: group/type BRISC complex=mapped→GO:0070552 BRISC complex (already_in_goa_exact); group ...|DNA repair=mapped→GO:0006281 DNA repair (new_to_goa); class Ubiquitin and UBL binding=context_only (too_broad).
Consistency: Deep-research notes, review YAML, and PN-node BRISC mapping all agree ABRAXAS2 (=ABRO1/FAM175B) is a noncatalytic BRISC scaffold/adaptor, not a catalytic JAMM DUB. Partial contradiction at the DNA-repair node: the PN row-2 group projects broad GO:0006281 DNA repair, but the review and notes explicitly argue ABRO1 lacks the BRCA1-interacting motif and does NOT join BRCA1-A/DNA-repair sites (PMID:21282113), so direct DNA-repair propagation is rejected.
PN story / NEW pressure: BRISC complex membership is already captured (GO:0070552, IDA/IPI/NAS in GOA). The DNA-repair claim over-reaches for this paralog. The review instead adds well-supported NEW terms the PN node does not surface: GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator (OLS-verified real; PMID:25283148, ABRO1 stabilizes p53 via USP7) and GO:0060340 positive regulation of type I interferon-mediated signaling (PMID:24075985/31142841, BRISC-SHMT2/IFNAR1), plus NuMA spindle-assembly terms. Conclusion: BRISC = already captured; DNA repair = PN over-reaches; p53-DDR signaling = legitimate ADD already done in review.
Mapping strategy: The BRISC node mapping is correct and stable. The ...|DNA repair group node should not propagate GO:0006281 to ABRAXAS2 — the p53-class mediator is a paralog-specific signaling role, not direct repair. This mirrors the precedent of suppressing an over-broad projected term for a specific gene.
Evidence alignment: PN row references (PMID:36473924, 19261749) overlap the review's BRISC/polyubiquitin-binding evidence (PMID:19261749 used, marked over-annotated as BRCA1-A-specific). Review extends far beyond PN refs (PMID:21282113, 20656690, 24075985, 25283148, 26195665, 31142841, 31253574) — divergence is enrichment, not conflict.
Verdict: Consistent on BRISC; PN DNA-repair projection over-reaches and is correctly declined; review's p53-DDR/IFN NEW terms are sound. Recommended edits: [MAP] Do not project GO:0006281 DNA repair to ABRAXAS2; the supported DNA-damage role is GO:0043517 (p53-class DDR signaling), already added in the review.