PN placement:Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease ; PN-node mapping: group mapped ok_for_propagation GO:0005759 mitochondrial matrix; class mappedGO:0035694 mitochondrial protein catabolic process; branch no_mapping.
Consistency: Deep research (falcon), review YAML, and PN annotation agree on the core picture: AFG3L2 is the m-AAA inner-membrane AAA+/M41 zinc metalloprotease performing mitochondrial protein QC, processing (MRPL32), and regulated degradation (EMRE, SLC25A39/45, PINK1, TMBIM5). One deliberate, well-flagged divergence: the PN group projects GO:0005759 mitochondrial matrix as the localization target, but the review rejects this (AFG3L2 is an integral inner-membrane protein with matrix-facing catalytic domains) and keeps GO:0005743 mitochondrial inner membrane. The NEW row's reason explicitly states the matrix projection is not accepted. No contradiction beyond this intentional correction.
PN story / NEW pressure: PN class target GO:0035694 mitochondrial protein catabolic process (verified real, non-obsolete) is added as a NEW (IC) annotation and used to MODIFY the generic GO:0006508 proteolysis / GO:0030163 protein catabolic process rows. Defensible and conservative — directly supported by SLC25A39 degradation papers (PMID:37917749, 38157846). Verdict: ADD (already implemented in review).
Mapping strategy: Gene refines, does not change, the node. The class→GO:0035694 mapping is correct and adopted. The group→GO:0005759 matrix mapping is too specific/wrong-compartment for AFG3L2; review's rejection is sound (matrix-facing topology ≠ matrix residence).
Evidence alignment: PN dossier carries no reference titles; review is densely evidenced (PMID:31327635, 29932645, 19748354, 27642048, 28396416, 37917749, 38157846, 41075794). PN projection TSV is cited as supporting file for GO:0035694. No PMID-level conflicts.
Verdict: Consistent; PN GO:0035694 correctly adopted as NEW; PN matrix (GO:0005759) projection correctly overruled at gene level. Recommended edits: none required. Optional [MAP]: flag mitochondrial-proteostasis "Matrix protease" group GO:0005759 as too specific for inner-membrane matrix-facing proteases (consider GO:0005743 or no_mapping).