ANAPC2

UniProt: Q9UJX6 (APC2) · batch: proteostasis-batch-2026-06-03 (Falcon DR 2026-06-07) · review status: COMPLETE
PN placement: 3 rows, UPS. (1) …Cullin|degenerate, APC sununit; (2) …idiosyncratic RING complex|Anaphase Promoting Complex|catalytic / core; (3) …Ubiquitin and UBL binding|E3 ligase complex component|APC / catalytic subunit. PN-node mapping: Cullin group=mapped→GO:0160072 scaffold activity (new_to_goa); APC type=mapped→GO:0005680 anaphase-promoting complex (already_in_goa_exact); RING-complex/E3-component groups=mapped→GO:0000151 ubiquitin ligase complex (entailed_by_goa_closure).
Consistency: Fully consistent. DR ↔ notes ↔ YAML ↔ PN all converge: ANAPC2 is the cullin-like scaffold subunit of the APC/C catalytic module (Apc2-Apc11). No contradiction.
PN story / NEW pressure: PN projects three terms; review handles each correctly. GO:0005680 already_in_goa → ACCEPT (IBA). GO:0000151 entailed via GO:0005680/GO:0031461 → correctly NOT added. GO:0160072 ubiquitin ligase complex scaffold activity (verified real, new_to_goa): review ADDS as action: NEW (IC, PMID:26083744) only after gene-level scrutiny of structural literature (Apc2-Apc11 catalytic module; PMID:11739784 minimal module, 16364912). Defensible — APC2 is a degenerate cullin scaffold. Conclude: ADD (GO:0160072), others already captured/entailed.
Mapping strategy: ANAPC2 supports, rather than changes, the node mappings. The Cullin-group scaffold projection is precisely the term gene-level review accepts; APC and ligase-complex memberships are appropriately already-in/entailed. Scopes (ok_for_propagation) correct; no broader/narrower mismatch.
Evidence alignment: PN cites PMID:16763193, 21107322, 29167309, 27259151, 31350353. Review uses overlapping structural set (16364912, 26083744, 11739784, 18485873, 29033132) plus DR additions PMID:37735619 (TR cryo-EM E2 docking), 39567505 (APC2 Zn module), 36548081 (DEPTOR substrate) as statement-only. Good overlap on APC/C catalytic-module structure; review enriches with newer cryo-EM.
Verdict: Consistent; GO:0160072 NEW warranted and matches PN (new_to_goa). GO:0005680 ACCEPT, GO:0000151 correctly entailed. No over-reach.
Recommended edits: none to ANAPC2-ai-review.yaml; PN mappings sound as-is.