ATP6V0A1

UniProt: Q93050 · batch: proteostasis-batch-2026-06-03 · review status: COMPLETE
PN placement: ALP|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component (also ...|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0...) ; PN-node mapping: subtype mapped→GO:0046610 lysosomal V0 domain (Pre-init leaf, more_specific_than_existing_goa) / GO:0033179 V0 domain (Lysosomal leaf, already_in_goa_exact); type mapped→GO:0007042 lysosomal lumen acidification.
Consistency: Consistent. Notes/review YAML, PN annotation, and PN-node mapping all describe ATP6V0A1 as the brain-enriched V0 a1-subunit of the lysosomal/synaptic-vesicle V-ATPase. Review ACCEPTs generic GO:0033179 ("already consistent with the PN projection") and ADDED GO:0046610 (action: NEW, IC, part_of) as the lysosome-specific refinement. No contradictions.
PN story / NEW pressure: PN's lysosome-specific V0 term (GO:0046610) was more_specific_than_existing GOA; review correctly ADDED it, supported by ATP6V0A1 disease variants impairing lysosomal/endolysosomal acidification (PMID:33833240, 34909687). Generic V0 (GO:0033179) and acidification (GO:0007042) already captured. Verdict: one ADD (GO:0046610), rest already-captured — no over-reach.
Mapping strategy: Gene supports node mapping; projected lysosomal-V0 term is narrower than the existing generic V0/complex annotations — an appropriate refinement. Notably the review used evidence code IC for the NEW row (vs TAS in the parallel ATP6V0C review) — a minor cross-gene inconsistency in how the same PN-derived lysosomal-V0 refinement is coded.
Evidence alignment: PN cites the same V-ATPase/mTORC1 review set as ATP6V0C. Review anchors claims to gene-specific disease/functional papers (PMID:33833240 ATP6V0A1 variants; PMID:34909687 endolysosome acidification; PMID:33065002 structure) — more primary and gene-specific than the PN row. Convergent direction.
Verdict: Consistent; PN lysosomal-V0 projection correctly ADDED (NEW GO:0046610). Optional: harmonize NEW-row evidence code with ATP6V0C (IC vs TAS).
Recommended edits: [YAML] Consider aligning the GO:0046610 NEW-row evidence code between ATP6V0A1 (IC) and ATP6V0C (TAS) for consistency across the V0 PN refinements (low priority; both are defensible).