ATP6V0C

UniProt: P27449 · batch: proteostasis-batch-2026-06-03 · review status: COMPLETE
PN placement: ALP|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component (also ...|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0...) ; PN-node mapping: subtype mapped→GO:0046610 lysosomal V0 domain (Pre-init leaf, more_specific_than_existing_goa) / GO:0033179 V0 domain (Lysosomal leaf, already_in_goa_exact); type mapped→GO:0007042 lysosomal lumen acidification (already_in_goa_exact). GO:0046610 verified real (OLS).
Consistency: Consistent. Four deep-research files (openai/falcon/perplexity/cyberian), review YAML, PN annotation, and PN-node mapping all describe ATP6V0C as the c-ring proteolipid of the V0 sector driving organelle/lysosomal acidification. Review ADDED GO:0046610 (action: NEW, part_of, TAS) as a lysosome-specific refinement and ACCEPTs GO:0007042 and GO:0033179. mTORC1/Wnt roles held non-core. No contradictions.
PN story / NEW pressure: PN's lysosome-specific V0 term (GO:0046610) was not previously in GOA; review correctly ADDED it as a conservative refinement of existing generic GO:0033179 + lysosomal-membrane annotations, declining the broader "autophagy-initiation/mTORC1 process" reading. Acidification (GO:0007042) and generic V0 (GO:0033179) already captured. Verdict: one ADD (GO:0046610), rest already-captured — correctly handled, no over-reach.
Mapping strategy: Gene supports node mapping. Projected lysosome-specific component term is narrower than the existing generic V0/complex annotations — an appropriate refinement, not an over-broad process projection. The dossier's two leaves redundantly target the same protein with V0/lysosomal-V0 terms, consistent with review.
Evidence alignment: PN cites V-ATPase/mTORC1 reviews (amino-acid sensing, SEA/GATOR, V-ATPase structure, neurodegeneration). Review anchors the same complex/acidification claims to the primary structural paper (PMID:33065002) and the V-ATPase review (PMID:32001091), plus disease-variant work (PMID:36074901). Convergent; review evidence is more primary. Review also correctly REMOVEs two ATP-synthase mis-annotations (GO:0015986, GO:0046933).
Verdict: Consistent; PN lysosomal-V0 projection correctly ADDED (NEW GO:0046610). No edits required.