ATP6V1F

UniProt: Q16864 · batch: proteostasis-batch-2026-06-06 · review status: COMPLETE (mature; ~45 annotations, full core_functions)
PN placement: Autophagy-Lysosome Pathway|...|V1 lysosomal v-ATPase proton pump component (two rows, identical pattern) ; PN-node mapping: subtype=mapped/ok GO:0046612 + GO:0033176; type=mapped/ok GO:0007042; ancestors no_mapping/context_only.
Consistency: Consistent. Notes ↔ review agree: F = smallest V1 subunit (13 kDa), central-rotor with D, interacts directly with V0 d subunit (PMID:18752060); ubiquitous housekeeping. Review correctly ACCEPTs complex/MF/process core terms and marks generic membrane/monoatomic-ion/intracellular-pH terms over-annotated. No PN/review contradiction.
PN story / NEW pressure: No over-reach, no unmet pressure. PN's mTORC1-upstream row is generic; the F review correctly does NOT add mTORC1/Ragulator annotations (no F-specific evidence) — defensible. GO:0007042 already in GOA (dossier: already_in_goa_exact; 2 hits) and ACCEPTed. GO:0046612 (verified real, OLS) absent from GOA — defensible more-specific ADD. GO:0033176 already in GOA (2 hits) ACCEPT.
Mapping strategy: F does not change node mapping. F GOA lacks lysosomal-specific complex CC (GO:0046611 absent); review's most specific complex term is GO:0016471 (vacuolar V-ATPase complex, IDA/ACCEPT). The subtype-complex projection GO:0033176 is broader; GO:0046612 V1-domain target is correctly specific.
Evidence alignment: Minimal overlap. PN cites generic V-ATPase/mTORC1 review titles; review anchors on F-specific primaries: PMID:8581736 (14-kDa F cloning), 18752060 (central stalk/d-subunit, IDA), 33065002 (cryo-EM), 32001091 (= one PN review, overlap). PN evidence non-F-specific.
Verdict: Consistent / ADD GO:0046612 (verified) as more-specific CC; no contradictions. Recommended edits: none required; mappings sound (broader GO:0033176 acceptable given F GOA lacks a lysosomal-specific complex term).