PN placement: two rows — Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy and ...|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Modulator of class 3 PI3K complex 1 activity|Modulator of BECN1 availability ; PN-node mapping: Mitophagy type → mapped/ok GO:0000423 mitophagy (goa_status=supported_by_goa_regulation); BECN1-modulator path → context_only/too_broad GO:0035032 (class III PI3K complex), class → context_only GO:0016236.
Consistency: Consistent. PN (mitophagy receptor + BECN1-availability modulator via atypical BH3), the review, notes and Falcon deep research all agree: NIX is an OMM tail-anchored mitophagy receptor (LIR→LC3/GABARAP; PMID:20200478) that under hypoxia also promotes pro-survival macroautophagy by disrupting Bcl-2-Beclin1 (PMID:19273585). PN row 1 = review core (mitophagy); PN row 2 = review's hypoxia/BECN1 axis. No contradictions.
PN story / NEW pressure: PN row-1 GO:0000423 mitophagy is correctly "supported_by_goa_regulation" — the review carries GO:1901524 regulation of mitophagy (ACCEPT, IEA) so the process is already captured. The genuine NEW pressure is the MF: the review proposes a new term "mitophagy receptor activity" claiming none exists. This is incorrect — GO:0140580 "mitochondrion autophagosome adaptor activity" already exists (def "binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy"), exactly the LIR-tethering activity. So the MF is already captured by a real term; ADD GO:0140580 rather than a new term. BECN1-modulator (class III PI3K) row is correctly context_only (NIX modulates, is not a complex subunit).
Mapping strategy: Row-1 mitophagy projection is fine (already in GOA via regulation term). Row-2 context_only/too_broad for GO:0035032 is correct (do not assign complex membership to a modulator) — consistent with the rejected-broader precedent.
Evidence alignment: PN cites review-style titles (Marinkovic FEBS Open Bio 2021; hypoxia BH3 paper = PMID:19273585; mitophagy-initiation BST review). Review uses PMID:20200478, 19273585, 21264228, 9973195, plus FBXL4/PPTC7 turnover refs. Strong overlap on the hypoxia and receptor papers.
Verdict: Consistent; mitophagy process already captured. Key finding: the review's proposed NEW "mitophagy receptor activity" term duplicates the existing GO:0140580. Recommended edits: [YAML][REF] replace the BNIP3L proposed_new_term "mitophagy receptor activity" with the existing GO:0140580 mitochondrion autophagosome adaptor activity (add as core MF, supported by PMID:20200478).