CDC37L1
- UniProt: Q7L3B6 · batch: proteostasis-batch-2026-06-07 · review status: COMPLETE
- PN placement:
Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain; PN-node mapping: leaf/group/class/branch allno_mapping;[type] HSP90 cochaperone→mappedGO:0051879 Hsp90 protein binding (more_specific_than_existing_goa). - Consistency: Consistent. Notes, YAML, and PN all frame CDC37L1 (Harc) as a cytoplasmic HSP90/HSP70 co-chaperone (CDC37 paralog). GO:0051879 verified real. The review's repeated MODIFY of bare GO:0005515 IPI rows (WITH HSP90AA1/AB1) → GO:0051879 directly matches the PN projection. No contradictions.
- PN story / NEW pressure: PN asserts Hsp90 binding (GO:0051879), which is not present verbatim in GOA (GOA has GO:0031072 heat shock protein binding IBA + bare GO:0005515 IPI to HSP90AA1/AB1). The review already proposes GO:0051879 via MODIFY of the IPI rows, so the PN story is captured by the review and defensibly more specific than the existing heat-shock-protein-binding parent. ADD is effectively already in the review; no over-reach.
- Mapping strategy: No change. PN maps conservatively at the
[type]altitude (cochaperone), with the family/system containers left unmapped — appropriate given CDC37 vs CDC37L1 client divergence.more_specific_than_existing_goais accurate (GO:0051879 is a child concept of the generic heat shock / protein binding annotations). - Evidence alignment: PN listed no reference titles for this row. Review evidence is genome-scale interactome screens (PMID:25036637 Taipale chaperome map is the most informative; PMID:21988832/25416956/33961781/40205054). WITH partners (HSP90AA1 P07900, HSP90AB1 P08238, STIP1 P31948) underpin the GO:0051879 call. No divergence.
- Verdict: Consistent; PN's GO:0051879 is defensible and already operationalized in the review (MODIFY of IPI rows). No new pressure beyond the review.
Recommended edits: None required. (Review already maps the HSP90-binding IPI evidence to GO:0051879, aligning with the PN node.)