CLCN7

UniProt: P51798 · batch: proteostasis-batch-2026-06-07 · review status: COMPLETE
PN placement: Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification ; PN-node mapping: the leaf and most ancestors are no_mapping; the [type] node "Lysosomal acidification" is mapped, ok_for_propagation_to_go, GO:0007042 lysosomal lumen acidification (verified real; not in GOA → new_to_goa).
Consistency: Strongly consistent. Deep-research notes, review YAML, and PN row all describe ClC-7 as the 2Cl(-)/1H(+) lysosomal antiporter (not a passive channel) that supports V-ATPase acidification. The single PN reference (PMID:18449189, "primary chloride permeation pathway in lysosomes") is the central paper in both the notes and the YAML. No contradictions.
PN story / NEW pressure: PN emphasizes ClC-7's contribution to lysosomal acidification (GO:0007042), which is absent from existing GOA. The review captures the molecular mechanism (GO:0062158 antiporter; GO:1902600 proton transport) but does NOT annotate the acidification process itself. GO:0007042 is a defensible, verified ADD — directly supported by PMID:18449189 (siRNA knockdown diminishes lysosomal acidification). Note the literature nuance (normal steady-state pH in Clcn7-/- mice; PMID:32851177) means an involved_in (contributory), not causal, framing is appropriate.
Mapping strategy: No change needed. The PN node maps at the correct (type) altitude with conservative parents left unmapped. GO:0007042 is neither broader than the review nor a TOMM20-style over-reach; it is a genuine process gap.
Evidence alignment: Full overlap on PMID:18449189. Review additionally cites PMID:21527911 (stoichiometry), PMID:32851177 (cryo-EM/complex). No divergence.
Verdict: Consistent; ADD GO:0007042 lysosomal lumen acidification (involved_in) to the review.

Recommended edits: [YAML] Add an existing_annotations/proposed_new_terms entry or core_functions.directly_involved_in for GO:0007042 lysosomal lumen acidification (involved_in, supported_by PMID:18449189), framed as contributory.