PN placement:ER proteostasis|Folding enzyme|Protein disulfide isomerases ; PN-node mapping: group (Protein disulfide isomerases)→GO:0003756 protein disulfide isomerase activity (mapped/ok_for_propagation, goa_status=new_to_goa); class (Folding enzyme)→no_mapping; branch→no_mapping.
Consistency: Review, notes, and UniProt agree that ERP29 is a non-catalytic, redox-inactive PDI-family escort/chaperone — it has a thioredoxin-like fold but LACKS the CXXC (CGHC) active-site motif and is NOT a disulfide isomerase. The PN-node mapping CONTRADICTS this: the "Protein disulfide isomerases" group projects GO:0003756 positively onto ERP29, but ERP29's only GOA annotation to GO:0003756 is NOT|enables (IKR, PMID:9738895) and the review ACCEPTs that negation. So the PN group rationale ("catalytically active family members") is correct only for the catalytic PDIs — ERP29 is the family exception, mis-swept into the group projection.
PN story / NEW pressure:GO:0003756 (VERIFIED real via OLS) is a catalytic isomerase activity ERP29 demonstrably does not have. This is not a defensible NEW term for ERP29 — it directly opposes the negated experimental annotation and the no-CXXC biology. The review's true core MF is GO:0051087 protein-folding chaperone binding (ACCEPT), already captured. Conclude: OVER-REACHES (worse — actively contradicted), do NOT add.
Mapping strategy: This gene SHOULD change the group projection. The catalytic-PDI mapping (GO:0003756) is the right target for active members (PDIA1, etc.) but must NOT propagate to the non-catalytic ERP29; the group node needs a per-member exclusion or ERP29 should map to a chaperone-binding/escort term (GO:0051087) instead.
Evidence alignment: PN node carries no reference titles. Review well-anchored: PMID:9738895 (lacks CXXC; founding characterization, VERIFIED) and PMID:12475965 (ER chaperone multiprotein complex, VERIFIED). No shared evidence supports a disulfide-isomerase-activity claim; the cited PMID:9738895 in fact establishes the opposite.
Verdict: OVER-REACHES / CONTRADICTED — reject projected GO:0003756 for ERP29; the gene is a non-catalytic PDI member whose function is already captured by GO:0051087. Recommended edits: [MAP] do not propagate GO:0003756 to ERP29 (it carries a curated NOT for this term); exclude non-catalytic PDI-family members from the group's isomerase projection or re-map ERP29 to GO:0051087 protein-folding chaperone binding.