PN placement:UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR ; PN-node mapping: group Cul1 substrate receptor=mapped/ok_for_propagation→GO:1990756; F-box/LRR subtype+type=no_mapping; class=context_only/too_broad→GO:0061630.
Consistency: Fully consistent. Falcon DR (cardiac Z-disc adaptor; ACTN2/FLNC substrates; zebrafish contractility; denervation atrogene), review YAML, the PN F-box LRR receptor placement, and the GO:1990756 group mapping all converge. No contradictions.
PN story / NEW pressure: PN projects GO:1990756 (verified real) as new_to_goa. Review does not add it as NEW but reaches the same endpoint via action: MODIFY of the existing GO:0061630 ubiquitin protein ligase activity (IDA, PMID:22972877) → proposed_replacement GO:1990756 — the canonical F-box correction (catalysis is in RBX1, not the receptor). Net effect = adaptor MF present, matching PN. Conclude: already addressed by review via MODIFY; concordant with PN projection.
Mapping strategy: Gene supports the node. KEY PATTERN exemplary: review explicitly demotes the catalytic ligase MF (the MGI IDA "ligase activity," which over-attributes RBX1 chemistry to the receptor) to the GO:1990756 adaptor term. PN class-level GO:0061630 correctly flagged too_broad. No broader/narrower mismatch.
Evidence alignment: PN reference is only "15340381 / rev"; review anchors on the gene-defining PMID:22972877 (HIGH/VERIFIED — Z-disc, ACTN2/FLNC, SKP1/CUL1, in vivo contractility) plus FBXL review PMID:33234069 and Falcon DR. Divergence benign — PN generic family review vs review's primary cardiac study.
Verdict: Consistent; adaptor MF (GO:1990756) supplied via MODIFY of the mis-attributed catalytic term, matching PN. No over-reach.
Recommended edits: none to FBXL22-ai-review.yaml; PN mappings sound as-is.