PN placement:UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA ; PN-node mapping: group Cul1 substrate receptor=mapped/ok_for_propagation→GO:1990756; F-box/FBA subtype+type=no_mapping; class=context_only/too_broad→GO:0061630.
Consistency: Consistent on substance; one nuance. Falcon DR, review YAML, and the PN FBA F-box receptor placement converge on FBXO2 as a lectin-type SCF substrate receptor for glycoprotein-ERAD. SPECIAL CASE confirmed: FBA = real carbohydrate-binding MF (GO:0030246, verified real), recognizing the innermost Man3GlcNAc2 N-glycan core on misfolded glycoproteins.
PN story / NEW pressure: PN projects the generic GO:1990756 adaptor term (new_to_goa). The review's chosen core MF is the more informative, substrate-class-specific GO:0030246 carbohydrate binding (ACCEPT, already in GOA via IEA/keyword Lectin) — a genuine lectin activity beyond bare adaptor binding. Review also correctly demotes catalytic TAS GO:0004842/GO:0061630 to non-core/contributes_to. Conclude: PN adaptor term is captured at family level but the gene's distinctive MF (carbohydrate binding) is already in GOA and is the better core — no new term needed; FBXO2 lectin function over-rides the generic adaptor projection.
Mapping strategy: Gene refines, does not change, the node. The GO:1990756 group projection is the lowest-common-denominator F-box MF; for the FBA lectin subfamily the more specific GO:0030246 is preferable and already present, so the projection is not wrong but is broader than the gene's best MF. Consider noting FBA-lectin subfamilies carry carbohydrate binding as the distinguishing MF.
Evidence alignment: PN reference only "15340381 / rev"; review draws on PMID:10531035 (family), PMID:18203720-equivalent FBA-lectin work (cited heavily for FBXO6), PMID:34515398 (xenophagy/glycan, HIGH/VERIFIED), PMID:34445249, plus Falcon DR (Yoshida/Suzuki reviews, lysophagy). Strong gene-specific evidence; PN family review is a subset.
Verdict: Consistent; core MF correctly GO:0030246 (lectin, in GOA) rather than the generic PN adaptor term. No over-reach; secondary xenophagy/lysophagy/synaptic roles kept non-core.
Recommended edits: none to FBXO2-ai-review.yaml. [MAP] Optionally annotate FBA-lectin F-box subfamily nodes so carbohydrate binding (GO:0030246) is recognized as their distinguishing MF alongside the generic GO:1990756.