PN placement:UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA ; PN-node mapping: group Cul1 substrate receptor=mapped/ok_for_propagation→GO:1990756; F-box/FBA subtype+type=no_mapping; class=context_only/too_broad→GO:0061630.
Consistency: Consistent. Falcon DR (NGLY1/NFE2L1 axis, proteasome bounce-back), review YAML, and the PN FBA F-box receptor placement converge. SPECIAL CASE confirmed: FBA lectin (GO:0030246, verified real) binding high-mannose/complex/sulfated glycans (chitobiose core essential, PMID:18203720), feeding glycoprotein-ERAD; plus a documented CHK1-degradation/checkpoint role (PMID:19716789, IDA).
PN story / NEW pressure: PN projects the generic GO:1990756 adaptor term (new_to_goa). Review's core MF is GO:0030246 carbohydrate binding (ACCEPT, already in GOA; experimentally grounded by PMID:18203720 glycan-array) — more informative than the generic adaptor. Catalytic GO:0061630 correctly held at contributes_to/non-core. The CHK1/DNA-damage-checkpoint role (GO:0000077) is a real second process kept non-core; review aptly MARK_AS_OVER_ANNOTATED for the GO:0006281 DNA repair term (FBXO6 terminates CHK1, is not a repair factor). Conclude: gene's distinctive lectin MF already captured; generic PN adaptor term not the best core.
Mapping strategy: Gene refines, does not change, the node — same as FBXO2. GO:1990756 group projection is the safe family MF; GO:0030246 is the more specific, already-in-GOA MF for the FBA-lectin subfamily. PN class GO:0061630 correctly too_broad.
Evidence alignment: PN reference only "15340381 / rev"; review uses gene-specific PMID:18203720 (HIGH/VERIFIED, lectin+SCF), PMID:19716789 (HIGH/VERIFIED, CHK1), PMID:34445249/ComplexPortal CPX-7905, plus Falcon DR (Fujihira/Suzuki NGLY1 review, NFE2L1). PN family review is a subset; good overlap on the SCF-receptor framing.
Verdict: Consistent; core MF correctly GO:0030246 (lectin, in GOA) over the generic PN adaptor term; CHK1 checkpoint role non-core; GO:0006281 over-annotation flagged. No over-reach.
Recommended edits: none to FBXO6-ai-review.yaml. [MAP] As for FBXO2, FBA-lectin subfamily nodes could carry GO:0030246 as the distinguishing MF in addition to GO:1990756.