PN placement (2 rows): Row1 UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40 (PMID:15340381); Row2 UPS|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40 (PMID:21070969). PN-node mapping: Row1 group=mapped GO:1990756; Row2 group=mapped GO:0061630 ubiquitin protein ligase activity (new_to_goa); both class nodes context_only/too_broad.
Consistency: Row1 consistent — review treats FBXW4 (dactylin/SHFM3) as an SCF substrate receptor (GO:0019005 IBA/NAS ACCEPT, GO:0031146 ACCEPT, proposed_new_terms GO:1990756) with substrates UNDEFINED; deep research (Lockwood 2013) confirms F-box-dependent SKP1/CUL1/RBX1 + COP9 assembly and MG132-dependent association with ubiquitinated proteins. Row2 INCONSISTENT/over-reach: the PN "idiosyncratic Ub binding | E3 ligase" node projects GO:0061630 (catalytic ubiquitin protein ligase activity). PMID:21070969 (Pashkova 2010, Mol Cell, DOI) — per PubMed, "WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins" — describes the WD40 propeller as a ubiquitin-BINDING module promoting F-box auto-ubiquitination/turnover, NOT ligase catalysis. F-box proteins are non-catalytic receptors (catalysis is RBX1 RING). Both the paper's content and the F-box pattern contradict GO:0061630.
PN story / NEW pressure: Row1 ADD GO:1990756 (verified real, new_to_goa) — defensible, already proposed by review. Row2 GO:0061630 over-reaches twice (wrong activity type AND wrong paper interpretation). If anything, PMID:21070969 supports GO:0043130 ubiquitin binding (verified real; molecular function), not ligase activity. Limb-development role (SHFM3, dactylaplasia) is correctly KEEP_AS_NON_CORE / positional, not a molecular function.
Mapping strategy: Row1 correct. Row2 mapping is wrong:GO:0061630 should not be projected to F-box receptors from this Ub-binding paper. Recommend the Row2 node project GO:0043130 ubiquitin binding (if at all) or no_mapping — analogous to FBXW7's IBA ubiquitin-binding which the curator marked over-annotated.
Evidence alignment: Row1 PN cites PMID:15340381 (family review). Review uses PMID:10405324/PMID:10471509 (SHFM3/dactylaplasia, HIGH), PMID:10945468, plus falcon (Lockwood 2013). Row2 PN's PMID:21070969 is NOT in the review and its claim (Ub-binding) is mischaracterized by the GO:0061630 mapping.
Verdict: Row1 CONSISTENT (ADD GO:1990756). Row2 PN node OVER-REACHES. Recommended edits: [MAP] change Row2 group Ubiquitin and UBL binding|E3 ligase projection for FBXW4 from GO:0061630 ubiquitin protein ligase activity to GO:0043130 ubiquitin binding, or set no_mapping — PMID:21070969 documents WD40 ubiquitin BINDING (regulating F-box turnover), not catalytic ligase activity; F-box proteins are non-catalytic.