PN placement:ALP → Lysosomal catabolism → Lysosomal lipid catabolism → Lysosomal sphingomyelin/ceramide metabolism → Lysosomal ceramidase AND ALP → Autophagic lysosome reformation → Specific function in autophagic lysosome reformation unknown (2 rows)
PN-node mapping: ceramidase subtype/type = no_mapping (mixed ASAH1/GALC/GBA1 bucket; no safe shared ceramidase term); lipid-catabolism group = context_only → GO:0016042; catabolism class = no_mapping; ALR class = context_only/too_broad → GO:0007040 lysosome organization; ALR group ("function unknown") = no_mapping; branch no_mapping.
Consistency: Excellent — the best-aligned of the set. Deep-research, review, PN, and mapping converge: core function is lysosomal acid glucosylceramidase (GO:0004348; LIMP-2/SCARB2-trafficked), and the ALR/Parkinson axis is a genuine but downstream/mechanism-unknown consequence of GCase loss. The review's handling (GO:0007040 lysosome organization; regulation of macroautophagy; "current GO lacks an autophagic lysosome reformation term") mirrors the PN node's context_only→GO:0007040 + "function unknown"→no_mapping exactly. No contradictions.
PN story / NEW pressure: The PN's ALR placement asserts a role not captured by an exact GO term — and the review correctly recognizes this. OLS confirms there is NO existing GO term "autophagic lysosome reformation" (only GO:0061739 = "protein lipidation involved in autophagosome assembly", unrelated). The review already mints the right response: proposed_new_terms includes "autophagic lysosome reformation" (parent GO:0007040) — candidate, correctly unverified/new — plus "lysosomal glucosylceramide catabolic process" (parent GO:0006680). No fabricated existing term used. Already captured (proposed_new_terms + suggested_questions); no further ADD warranted.
Mapping strategy: No change. Including GBA1 does not alter the node: the ALR group is rightly no_mapping ("function unknown"), the class rightly context_only→GO:0007040 (broader than GBA1's enzymatic core), and the ceramidase bucket rightly no_mapping (GBA1 is a glucosylceramidase, not a ceramidase — the PN's mixed ASAH1/GALC/GBA1 grouping is appropriately not propagated). PN-projected GO:0007040 is broader than the review's enzyme-level core, so non-propagation is the right call (cf. rejected broader projections).
Evidence alignment: Strong overlap. PN cites the ALR paper (Magalhaes et al., HMG 2016) = PMID:27378698 (verified via PubMed, DOI 10.1093/hmg/ddw185), and the review cites the SAME PMID:27378698 for ALR (in core_functions, the GO:0007040 annotation, and the proposed ALR term). PN's other refs (Schröder lysosome proteome; hLGDB) are localization/database context not needed by the review.
Verdict: Fully consistent; exemplary handling of a "GO-gap" PN node (proposed NEW term instead of forcing an existing one), with matching primary evidence. Recommended edits: none.