RNF170

RNF170

• UniProt: Q96K19 · batch: proteostasis-batch-2026-06-11 · review status: COMPLETE (thorough; multi-pass ER RING E3, IP3R-ERAD core + TLR3, ERLIN complex, SPG85/SNAX1 disease)
• PN placement: 3 rows — ER proteostasis|...|ERAD|...|ERAD-associated RING E3 ligase; UPS|...|RING|with transmembrane domain|ER; UPS|...|idiosyncratic RING complex|RNF170 / ERLIN complex|catalytic / RING, transmembrane. PN-node mapping: ERAD-RING subtype→GO:0061630 (in_goa); ERAD type→GO:0036503 (new_to_goa); ERAD group→GO:0036503 exact (new_to_goa); RING group→GO:0061630 (in_goa); RNF170/ERLIN-complex group→GO:0000151 ubiquitin ligase complex (new_to_goa). Projected: GO:0036503×2 (new), GO:0061630×2 (in GOA), GO:0000151 (new).
• Consistency: Excellent and notably aligned on the NEW pressure. Deep research, review and PN all foreground the IP3R/ITPR1 ERAD with the ERLIN1/ERLIN2 complex (PMID:21610068, verified via PubMed DOI) as the defining function that is currently ABSENT from the GOA — the review marks GO:0036503 ERAD pathway as action NEW for exactly this reason, matching the dossier goa_status=new_to_goa for GO:0036503. GOA confirmed to lack GO:0036503 and GO:0000151. No contradictions.
• PN story / NEW pressure: GO:0036503 ERAD pathway (verified real) is genuinely new_to_goa here — the review already proposes adding it (NEW) plus a substrate-specific child term "inositol 1,4,5-trisphosphate receptor catabolic process via the ERAD pathway" (proposed_new_terms, parent GO:0036503). PN's GO:0036503 projection = ADD, fully concordant. GO:0000151 ubiquitin ligase complex (verified real, NOT in GOA) is grounded by the constitutive ERLIN1/2 association — DEFENSIBLE ADD; the review does NOT currently capture complex membership (no GO:0000151). Conclude: ERAD ADD strongly justified (review agrees); GO:0000151 a defensible ADD the review missed.
• Mapping strategy: Correct. Catalytic RING → GO:0061630; ERAD group/type → GO:0036503 (exact); ERLIN-complex group → GO:0000151 (membership, conservative). The ERLIN/RNF170 module is ER-membrane, so child GO:0000835 ER ubiquitin ligase complex (verified in OLS) would be more precise. No node-status change warranted.
• Evidence alignment: Strong. PN ERLIN row cites "1610068" (truncated PMID = 21610068, the Lu et al. founding IP3R-ERAD paper) and "41481136" (UNVERIFIABLE — does not resolve as a PMID; likely a typo/garbled ID). Review's IP3R-ERAD evidence (PMID:21610068, 31636353, 38782601) is richer; the SNAX1/SPG85 genetics tie ligase activity to disease. PN RING row "19489725 / rev" not in review (family review).
• Verdict: Fully consistent and mutually reinforcing on the IP3R-ERAD NEW story; review already proposes the ERAD ADD. GO:0000151 complex membership is a defensible addition the review omits.
• Recommended edits: [YAML] add GO:0000151 ubiquitin ligase complex (or child GO:0000835 ER ubiquitin ligase complex; part_of, PMID:21610068/38782601 ERLIN1/2 association) as a non-core CC — currently absent from the review. [REF] verify PN row-3 reference "41481136" — does not resolve as a valid PMID (likely garbled); confirm intended citation.