Consistency: Partial mismatch on the catalytic activity. Review, notes, and deep research converge that TXNDC11 is a disulfide reductase, not an isomerase/oxidase: only Trx5 carries a bona fide CXXC (CGFC, C692/C695), the other four Trx folds are degenerate, and Trx5 has reduction-potential (~−234 mV) behaving "as a reductase rather than an oxidase" (PMID:32065582; Timms 2016). The review's core MF and proposed_new_terms use GO:0015035 protein-disulfide reductase activity. The PN node projects GO:0003756 (isomerase). Verified via OLS: GO:0003756 (isomerase, S-S rearrangement) and GO:0015035 (reductase) are siblings under different parents, not parent/child — so GO:0003756 does not subsume the reductase function and is an over-projection for this specific member.
PN story / NEW pressure: Strong NEW pressure — TXNDC11 GOA has NO molecular-function term at all (only protein binding + localizations; verified goa.tsv). A catalytic MF should be added, but as GO:0015035 protein-disulfide reductase activity (verified real), not GO:0003756. The review also proposes a BP gap: glycoprotein ERAD (GO:0036503 ERAD pathway / GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway, both verified real) via the disulfide-linked EDEM2 mannose-trimming complex. Conclusion: ADD GO:0015035 (MF) + GO:0097466/GO:0036503 (BP).
Mapping strategy: The "Protein disulfide isomerases" group's GO:0003756 projection over-reaches for TXNDC11 specifically (it lacks canonical PDI isomerase activity). Group-level GO:0003756 may be right for canonical members but is the wrong activity class for this non-canonical reductase. The node mapping itself need not change, but TXNDC11 should be flagged as a group member whose projected isomerase term should NOT be propagated (scope exception), or projected as reductase.
Verdict: Inconsistent on activity class — PN GO:0003756 (isomerase) over-projects; review-supported activity is GO:0015035 reductase. MF is genuinely missing from GOA.
Recommended edits: [MAP] Flag TXNDC11 in the "Protein disulfide isomerases" group as a non-canonical reductase: do not propagate GO:0003756 to it; project GO:0015035 protein-disulfide reductase activity instead. [YAML] Optionally tighten the TXNDC11 proposed_new_terms to GO:0097466 (ubiquitin-dependent glycoprotein ERAD pathway) as the precise BP, and drop the GO:0003756 alternative wording in favor of GO:0015035.