UFSP2

UniProt: Q9NUQ7 · batch: proteostasis-batch-2026-06-07c · review status: COMPLETE
PN placement: two rows — Translation|Cytosolic translation|Ribosome-associated QC|UFMylation and Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase ; PN-node mapping: type/group both mapped, ok_for_propagation → GO:0071569 protein ufmylation, GO:0071567 deUFMylase activity, group-level GO:0006515 PQC (from RQC group); UPS class/branch no_mapping.
Consistency: Strong. Deep-research/notes, review YAML, PN annotation and PN-node mapping agree: UFSP2 is the principal human UFM1-specific cysteine protease (Cys302) that deUFMylates substrates (RPL26/uL24, CYB5R3, TRIP4, etc.) and processes pro-UFM1; ER-membrane-tethered, acting on 60S after RQC splitting. GOA cross-check confirms goa_status: GO:0071567 already-in-GOA (12 records), GO:0071569 new-to-GOA (0), GO:0006515 new-to-GOA (0). No contradictions.
PN story / NEW pressure: PN's deUFMylase/ufmylation story is captured (GO:0071567 multiple IDA/IMP/IBA). The RQC-specific biology is ALSO captured by review-only terms NOT generated from the PN node: GO:0072344 rescue of stalled cytosolic ribosome (IDA, PMID:38383785) and GO:0032790 ribosome disassembly (IDA) — these are more precise than the PN group's GO:0006515 and are already in the review. So GO:0006515 (new-to-GOA) is defensible-but-redundant for UFSP2; the better RQC terms already exist. No new term required.
Mapping strategy: Unlike UFSP1, the GROUP→GO:0006515/RQC projection IS biologically defensible for UFSP2 (RPL26 deUFMylation enabling 60S recycling after RQC). However the review already holds the narrower, IDA-backed GO:0072344 / GO:0032790; GO:0006515 is broader than these. UPS-side deUFMylase node anchoring is correct.
Evidence alignment: PN row 2 cites PMID:29476094 (UFSP review) — absent from the review YAML, which spans many primaries (PMID:38383785, 35926457, 36543799, 25219498, 31595041, 27926783, 33473208, 32160526, 36893266, 37795761). Same biology; PN reference is a secondary review not used in the YAML.
Verdict: Consistent and complete; PN-projected GO:0006515 is correct but broader than the review's already-present GO:0072344/GO:0032790.

Recommended edits: [MAP] the RQC-group GO:0006515 projection is acceptable for UFSP2 but redundant/broader than the review's existing GO:0072344 (rescue of stalled cytosolic ribosome) and GO:0032790 (ribosome disassembly); prefer those narrower IDA-supported terms when representing UFSP2's RQC role.