Focused function hypothesis
Hypothesis: The horse protein A0A3Q2KRK8 participates in cell projection organization.
Target: Equus caballus (NCBITaxon:9796), UniProt A0A3Q2KRK8. Gene label: WDPCP; verify identity independently rather than treating the label as proof.
Target GO claim: GO:0030030 — cell projection organization. Verify its definition and scope.
Decisive question
Evaluate the molecular scaffold and experimental basis for the broad cell-projection-organization process. Compare relevant mammalian structures and isoforms, and distinguish alterations affecting a specific biochemical property from those that undermine the whole process.
Identity and sequence inputs
- Target record: https://www.uniprot.org/uniprotkb/A0A3Q2KRK8/entry
- Human comparison lead: https://www.uniprot.org/uniprotkb/O95876/entry (WDPCP). Establish the relevant orthology/isoform relationship rather than assuming it.
- Frozen current UniProt sequence: 705 residues; SHA-256
a132072d392ff9ec8d0962a571a5ae3534476ecfc0679bdeb9051777f3aa5a0a. - These are current sequences downloaded for the cohort on 2026-09-08. Identity with the original prediction-time input has not been established. Evaluate the supplied sequence explicitly; document any different sequence used.
>A0A3Q2KRK8 Equus caballus WDPCP
MSFCLTELHLWSLKNTLHIGDRDIGVYQYYDKKDPPVTDHGNLEEKQKLAESRDYPWTLK
NRRPEKLRDSLKELEELMQNSQCVLSKWNNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDR
SLVGKLISDTISDALLTDSFIILSFFAQNKLCFIQFTKKMGSPDVNKRLEKLSALDYKIS
YYEIPGPVNRTTERRLAINCVQDIVVCWWPLVSDDAWPWAPISSEKNRANLLLLGYAQGR
LEVLSSVRTEWDPLDVRFGTKQPYQVLTVERSISVDKEPMADSCIYEYVRNKIHCVSVTR
IPLRSKAISCCRNVTEDKLILGCEDSSLILYETHRRVTLLAQAELLPSLICCHPTGSILL
VGSNQGELQIFDMALSPINIQLLAEDRSPRETLQFNKFFDVSSGLVQMQWIAPQVVSQKP
DSGDIYDLLFLRFDRGPLGVLLFKLGIFTRGQLGLVDIIFQYIHCDEICEAINILSSMNW
DTLGHQCFISMSAIVNHLLRQKLTPEREAQLEASLGTFYAPTRPLLDSTVLEYRDQISKY
ARRFFHHLLRYQRFEKAFLLAVDIGARDLFMDIHYLALDKGELALAEVARKKASDIDAES
ITSGVELLGPLHRGDTLNEAFVGLSLAPQREDTFPDNLPHFCSVHRHIIQQRTLNVSSNG
QVFNRRNKLEKDTCAGSLMPKTCNEEDQSFDVASYWKHQQWTMYA
Evidence and deliverable
Use primary literature and public sequence, structural and genomic resources. Select analyses that answer the decisive question; this is not a general gene review. Assess support and contrary evidence, and allow an unresolved outcome. Distinguish directly observed horse evidence, justified mammalian transfer, and results for a different protein model.
Do not consult the ai-gene-review repository's existing judgments, research syntheses or local bioinformatics analyses. Those are held out for comparison. Do not use agreement with ARBA or another prediction as biological validation. Preserve reproducible methods, accessions/versions, actual computation outputs and primary-source URLs/DOIs/PMIDs. Report the decisive findings and limitations, not just a verdict.