ARBA Rule Reviews Index
78 rule reviews. Includes reviews in progress; status and decisions reflect the source YAML.
Condition-set counts describe the sets recorded in each review, which may omit the full rule.
| Rule ID | Description | GO Terms | Status | Action | Parsimony | Literature | Recorded condition sets | Confidence |
|---|---|---|---|---|---|---|---|---|
| ARBA00000900 YAML |
Assigns the catalytic activity EC 2.3.2.27 (RING-type E3 ubiquitin transferase) through 304 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, 55 of them with a taxon. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 7 | Not recorded | |
| ARBA00001096 YAML |
Assigns the catalytic activity alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate (RHEA:16249, EC 5.1.3.15) to proteins matching three InterPro entries together: IPR025532 Glucose-6-phosphate 1-epimerase, IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase and IPR011013 Galactose mutarotase-like domain superfamily. | COMPLETE | ACCEPT | REDUNDANT | MODERATE | 1 | 0.80 | |
| ARBA00001712 YAML |
Assigns the catalytic activity alpha-D-galactose = beta-D-galactose (RHEA:28675, EC 5.1.3.3, galactose mutarotase) through two alternative condition sets: InterPro IPR008183 and IPR011013 in Metazoa, or CATH FunFam 2.70.98.10:FF:000003 in Eukaryota. | COMPLETE | ACCEPT | ACCEPTABLE | Not recorded | 2 | 0.80 | |
| ARBA00004173 YAML |
Assigns the UniProt subcellular location Mitochondrion (SL-0173) through 1,525 alternative condition sets built from CATH FunFam, InterPro and PANTHER signatures, each with a taxon condition. UniProt converts the location to GO:0005739 (mitochondrion) by GO_REF:0000044. | GO:0005739 mitochondrion |
COMPLETE | MODIFY | Not recorded | Not recorded | 14 | 0.75 |
| ARBA00004218 YAML |
ARBA rule assigning the subcellular location "Cytoplasmic vesicle, secretory vesicle, acrosome" through 38 alternative condition sets, each a conjunction of family signatures with a taxon condition. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 38 | Not recorded | |
| ARBA00004725 YAML |
ARBA rule assigning the pathway comment "Pyrimidine metabolism; UMP biosynthesis via de novo pathway" through 26 alternative condition sets built from InterPro, CATH FunFam, PANTHER and taxon conditions. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 26 | Not recorded | |
| ARBA00004841 YAML |
Assigns the pathway comment "Glycan metabolism; heparin biosynthesis" to chordate proteins that carry both the sulfotransferase domain (IPR000863) and the heparan sulphate N-deacetylase domain (IPR021930), or CATH FunFam 3.40.50.300:FF:000176. Both sets identify the bifunctional heparan sulfate N-deacetylase/N-sulfotransferases (NDST1-4). | COMPLETE | ACCEPT | Not recorded | Not recorded | 2 | 0.80 | |
| ARBA00005098 YAML |
Assigns the pathway comment "Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1" (the arginase step) through nine alternative condition sets: InterPro arginase signatures in Chordata, a PANTHER subfamily in Bacteria, and seven CATH FunFams of superfamily 3.40.800.10, each with its own taxon. | COMPLETE | ACCEPT | Not recorded | Not recorded | 9 | 0.80 | |
| ARBA00022438 YAML |
Assigns the UniProt keyword Aminopeptidase (KW-0031) through 90 alternative condition sets built from InterPro entries, PANTHER subfamilies and CATH FunFams, 38 of them with a taxon condition. | COMPLETE | ACCEPT | Not recorded | Not recorded | 90 | 0.80 | |
| ARBA00022487 YAML |
Assigns the UniProt keyword KW-0719 (Serine esterase) through 65 alternative condition sets built from InterPro, PANTHER and CATH FunFam signatures. | COMPLETE | ACCEPT | Not recorded | Not recorded | 65 | 0.60 | |
| ARBA00022603 YAML |
Assigns the UniProt keyword Methyltransferase (KW-0489) from 624 alternative condition sets of InterPro, FunFam, PANTHER and taxon conditions. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 0 | Not recorded | |
| ARBA00022670 YAML |
Assigns the UniProt keyword Protease (KW-0645) through 1010 alternative condition sets. About half are single InterPro entries or PANTHER families; the rest are conjunctions of two or three conditions, some with a taxon. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 10 | Not recorded | |
| ARBA00022679 YAML |
Assigns the UniProt keyword KW-0808 (Transferase) through 4,603 alternative condition sets built from InterPro, PANTHER and CATH FunFam signatures. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 10 | Not recorded | |
| ARBA00022722 YAML |
Assigns the UniProt keyword Nuclease (KW-0540) through 538 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams. 326 sets are conjunctions of two or more conditions and 153 carry a taxon condition. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 287 | Not recorded | |
| ARBA00022759 YAML |
Assigns the UniProt keyword Endonuclease (KW-0255) through 320 alternative condition sets. Each set is one to three InterPro entries or PANTHER families, in about a third of the sets with a taxon. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 11 | Not recorded | |
| ARBA00022777 YAML |
Assigns the UniProt keyword KW-0418 (Kinase) through 1,392 alternative condition sets built from InterPro, PANTHER and CATH FunFam signatures. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 10 | Not recorded | |
| ARBA00022801 YAML |
ARBA rule assigning the UniProt keyword Hydrolase (KW-0378) through 4171 alternative condition sets built from InterPro, PANTHER and taxon conditions. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 4 | Not recorded | |
| ARBA00022806 YAML |
ARBA rule assigning the UniProt keyword Helicase (KW-0347) through 335 alternative condition sets built from InterPro, PANTHER and taxon conditions. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 2 | Not recorded | |
| ARBA00022825 YAML |
Assigns the UniProt keyword Serine protease (KW-0720) through 244 alternative condition sets, each one to three InterPro entries or PANTHER families, in part with a taxon. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 10 | Not recorded | |
| ARBA00022912 YAML |
Assigns the UniProt keyword KW-0904 (Protein phosphatase) through 214 alternative condition sets built from InterPro, PANTHER and CATH FunFam signatures. | COMPLETE | ACCEPT | Not recorded | Not recorded | 214 | 0.60 | |
| ARBA00023002 YAML |
Assigns the UniProt keyword KW-0560 Oxidoreductase through 2158 alternative condition sets of InterPro, PANTHER and CATH FunFam signatures, some with a taxon condition. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 4 | Not recorded | |
| ARBA00023137 YAML |
ARBA rule assigning the UniProt keyword Tyrosine-protein kinase (KW-0829) through 100 alternative condition sets built from InterPro, CATH FunFam, PANTHER and taxon conditions. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 5 | Not recorded | |
| ARBA00023239 YAML |
Assigns the UniProt keyword KW-0456 Lyase through 908 alternative condition sets of InterPro, PANTHER and CATH FunFam signatures, some with a taxon condition. | IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 0 | Not recorded | |
| ARBA00026249 YAML |
ARBA rule assigning GO:0004791 thioredoxin-disulfide reductase (NADPH) activity through three condition sets: three thioredoxin reductase InterPro signatures together, a thioredoxin reductase FunFam in Eukaryota, and a second thioredoxin reductase FunFam in Glires. | GO:0004791 thioredoxin-disulfide reductase (NADPH) activity |
COMPLETE | ACCEPT | Not recorded | STRONG | 3 | 0.75 |
| ARBA00026302 YAML |
Assigns GO:1901137 carbohydrate derivative biosynthetic process through 188 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams; 94 sets carry a taxon condition. | GO:1901137 carbohydrate derivative biosynthetic process |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 188 | Not recorded |
| ARBA00026372 YAML |
Assigns GO:0051998 (protein carboxyl O-methyltransferase activity) through six alternative condition sets covering three enzyme families: isoprenylcysteine carboxyl methyltransferases (sets 1, 3, 4), protein-L-isoaspartate O-methyltransferases (sets 2, 5) and leucine carboxyl methyltransferase 1 (set 6). | GO:0051998 protein carboxyl O-methyltransferase activity |
COMPLETE | ACCEPT | Not recorded | Not recorded | 6 | 0.80 |
| ARBA00026480 YAML |
Assigns GO:0010605 negative regulation of macromolecule metabolic process through 343 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams; 107 sets carry a taxon condition. GO:0010605 is a high-level grouping term whose descendants include negative regulation of gene expression, mRNA catabolism and RNA-mediated gene silencing. | GO:0010605 negative regulation of macromolecule metabolic process |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 343 | Not recorded |
| ARBA00026572 YAML |
Assigns GO:0006139 nucleobase-containing compound metabolic process through 773 alternative condition sets of InterPro, PANTHER and CATH FunFam signatures, some with a taxon condition. | GO:0006139 nucleobase-containing compound metabolic process |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 0 | Not recorded |
| ARBA00026647 YAML |
Assigns GO:0010629 negative regulation of gene expression through 131 alternative condition sets of InterPro and CATH FunFam signatures, 59 of them with a taxon condition. | GO:0010629 negative regulation of gene expression |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 1 | Not recorded |
| ARBA00026698 YAML |
Assigns GO:0007034 vacuolar transport through 40 alternative condition sets, each a conjunction of InterPro or CATH FunFam signatures with a taxon. The sets cover ESCRT-III/Snf7-family proteins, ESCRT-I and ESCRT-II subunits, Vps4, sortilin/Vps10 and plant vacuolar sorting receptors, vacuolar syntaxins, GGA/VHS adaptors, NEDD4/Rsp5-type ubiquitin ligases and a few other families. | GO:0007034 vacuolar transport |
COMPLETE | ACCEPT | Not recorded | STRONG | 40 | 0.80 |
| ARBA00026708 YAML |
Assigns GO:0007031 (peroxisome organization) through 12 alternative condition sets that identify peroxins (PEX5, PEX7, PEX11, PEX12, PEX14/PEX33, the PEX28-PEX32 family), the dynamin-related fission GTPases DNM1/DRP3/DNM1L and VPS1, plant FIS1, and the fungal kinases KIN4 and FRK1. | GO:0007031 peroxisome organization |
COMPLETE | ACCEPT | Not recorded | Not recorded | 12 | 0.70 |
| ARBA00026799 YAML |
Assigns GO:0003951 (NAD+ kinase activity) from five alternative condition sets: one InterPro and PANTHER conjunction for the NAD kinase family, and four CATH FunFams each limited to a taxon. | GO:0003951 NAD+ kinase activity |
COMPLETE | ACCEPT | Not recorded | Not recorded | 5 | 0.75 |
| ARBA00026991 YAML |
Assigns GO:0015980 (energy derivation by oxidation of organic compounds) through 69 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, most with a taxon. The sets cover enzymes of glycolysis, the tricarboxylic acid cycle, respiratory electron transport and glycogen metabolism. | GO:0015980 energy derivation by oxidation of organic compounds |
COMPLETE | MODIFY | Not recorded | Not recorded | 69 | 0.60 |
| ARBA00027164 YAML |
Assigns GO:0006401 (RNA catabolic process) through 52 alternative condition sets built from InterPro, PANTHER and CATH FunFam signatures of RNA decay factors, most of them with a taxon condition. | GO:0006401 RNA catabolic process |
COMPLETE | ACCEPT | Not recorded | Not recorded | 52 | 0.70 |
| ARBA00027169 YAML |
Assigns GO:0120114 Sm-like protein family complex through 27 alternative condition sets of InterPro and CATH FunFam signatures, some with a taxon. The sets cover Sm and Lsm proteins and other protein components of the U1, U2, U5, U6, U7 and U11/U12 snRNPs. | GO:0120114 Sm-like protein family complex |
COMPLETE | ACCEPT | Not recorded | STRONG | 27 | 0.80 |
| ARBA00027389 YAML |
Assigns GO:0042546 cell wall biogenesis through 34 alternative condition sets. Every set combines one to three InterPro, PANTHER or CATH FunFam conditions with a taxon condition; the taxa range from single fungal and plant clades to Bacteria and "not Vertebrata". | GO:0042546 cell wall biogenesis |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 34 | Not recorded |
| ARBA00027399 YAML |
Assigns GO:0008236 (serine-type peptidase activity) through 45 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, most with a taxon. The sets cover coagulation and complement proteases, trypsin-family enzymes, subtilisin-like proprotein convertases, HtrA/DegP proteases, tripeptidyl peptidases and others. | GO:0008236 serine-type peptidase activity |
COMPLETE | MODIFY | Not recorded | Not recorded | 45 | 0.70 |
| ARBA00027430 YAML |
ARBA rule assigning GO:0006066 alcohol metabolic process through 83 alternative condition sets built from InterPro, CATH FunFam, PANTHER and taxon conditions. | GO:0006066 alcohol metabolic process |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 3 | Not recorded |
| ARBA00027624 YAML |
Assigns GO:0031090 organelle membrane through 472 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams; 107 sets carry a taxon condition. | GO:0031090 organelle membrane |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 60 | Not recorded |
| ARBA00027651 YAML |
Assigns GO:0004721 phosphoprotein phosphatase activity through 82 alternative condition sets of InterPro, PANTHER and CATH FunFam signatures, half with a taxon condition. | GO:0004721 phosphoprotein phosphatase activity |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 1 | Not recorded |
| ARBA00027723 YAML |
ARBA rule assigning GO:0016740 transferase activity through 1340 alternative condition sets built from InterPro, CATH FunFam, PANTHER and taxon conditions. | GO:0016740 transferase activity |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 0 | Not recorded |
| ARBA00027853 YAML |
Assigns GO:0006720 isoprenoid metabolic process through 89 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, 70 of them with a taxon condition. The sets cover terpene synthases and cyclases, prenyl diphosphate synthases, carotenoid synthesis and cleavage enzymes, gibberellin and abscisic acid oxidases, mevalonate pathway enzymes and retinoid-metabolising enzymes. | GO:0006720 isoprenoid metabolic process |
COMPLETE | MODIFY | Not recorded | Not recorded | 89 | 0.60 |
| ARBA00027994 YAML |
ARBA rule assigning GO:0006338 chromatin remodeling through 167 alternative condition sets built from InterPro, CATH FunFam, PANTHER and taxon conditions. | GO:0006338 chromatin remodeling |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 4 | Not recorded |
| ARBA00028131 YAML |
Assigns GO:0004175 (endopeptidase activity) through 104 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, most with a taxon. The sets cover caspases, papain-like and legumain cysteine peptidases, aspartic peptidases, proteasome subunits, signal peptidases, trypsin- and subtilisin-like serine peptidases and several metallopeptidase families. | GO:0004175 endopeptidase activity |
COMPLETE | MODIFY | Not recorded | Not recorded | 104 | 0.55 |
| ARBA00028334 YAML |
Assigns GO:0010468 regulation of gene expression through 929 alternative condition sets of InterPro, PANTHER and CATH FunFam signatures, some with a taxon condition. | GO:0010468 regulation of gene expression |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 0 | Not recorded |
| ARBA00028538 YAML |
ARBA rule that assigned GO:0046467 membrane lipid biosynthetic process through 51 alternative condition sets built from InterPro, CATH FunFam and taxon conditions. GO has made the term obsolete and UniProt no longer serves the rule. | GO:0046467 obsolete membrane lipid biosynthetic process |
COMPLETE | DEPRECATE | Not recorded | Not recorded | 51 | 0.95 |
| ARBA00028584 YAML |
Assigns GO:0005778 (peroxisomal membrane) through 16 alternative condition sets covering peroxins (PEX2/10, PEX4, PEX11, PEX12, PEX13, PEX14 and the fungal DysF-domain peroxins), peroxisomal ABC transporters, PMP34 (SLC25A17), ATAD1, fatty acyl-CoA reductase, NBR1 and a Penicillium transporter FunFam, each with a taxon restriction. | GO:0005778 peroxisomal membrane |
COMPLETE | ACCEPT | Not recorded | STRONG | 16 | 0.65 |
| ARBA00028655 YAML |
Assigns GO:0006661 (phosphatidylinositol biosynthetic process) from eleven alternative condition sets covering PI synthase, phosphoinositide kinases and phosphatases, and two lipid-transfer protein families. | GO:0006661 phosphatidylinositol biosynthetic process |
COMPLETE | MODIFY | Not recorded | Not recorded | 11 | 0.70 |
| ARBA00028665 YAML |
Assigns GO:0048468 (cell development) through 392 alternative condition sets. Every set is a conjunction of one to three InterPro entries, PANTHER families or CATH FunFams with a taxon. | GO:0048468 cell development |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 10 | Not recorded |
| ARBA00028985 YAML |
Assigns GO:0016070 (RNA metabolic process) through 375 alternative condition sets built from InterPro entries, PANTHER families and CATH FunFams, about a quarter of them with a taxon. | GO:0016070 RNA metabolic process |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 10 | Not recorded |
| ARBA00029057 YAML |
ARBA rule assigning GO:0065003 protein-containing complex assembly through 88 alternative condition sets built from InterPro, CATH FunFam, PANTHER and taxon conditions. | GO:0065003 protein-containing complex assembly |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 3 | Not recorded |
| ARBA00035048 YAML |
Assigns GO:0005681 (spliceosomal complex) through 19 alternative condition sets, each one or two InterPro entries or CATH FunFams with a taxon. The sets cover spliceosomal cyclophilins, DEAH-box helicases, Sm proteins, snRNP proteins and other splicing factors. | GO:0005681 spliceosomal complex |
COMPLETE | ACCEPT | Not recorded | Not recorded | 19 | 0.75 |
| ARBA00035068 YAML |
Assigns GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity through two condition sets: CATH FunFam 2.30.29.30:FF:000038 in Primates (MTM1, MTMR1, MTMR2) and CATH FunFam 3.30.40.10:FF:000073 in Eukaryota (the FYVE-domain region of MTMR3 and MTMR4). | GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity |
COMPLETE | MODIFY | Not recorded | Not recorded | 2 | 0.80 |
| ARBA00043370 YAML |
Assigns GO:0140115 (export across plasma membrane) through 14 alternative condition sets that identify efflux transporters: bacterial SMR and Emr multidrug exporters, fungal MFS and ABC drug exporters, plant ABCB auxin transporters, metazoan ABCG2, sodium-exporting P-type ATPases, Na+/K+-ATPase alpha subunits, fungal Na+/H+ antiporters and Na+/Ca2+ exchangers. | GO:0140115 export across plasma membrane |
COMPLETE | ACCEPT | Not recorded | Not recorded | 14 | 0.60 |
| ARBA00045851 YAML |
Assigns a FUNCTION comment describing assembly of a p53/TP53 suppression complex that tethers SIRT1 and MDM2, and a possible role in spermatogenesis, to proteins of the MORN repeat-containing protein 3 family across Eukaryota. | COMPLETE | MODIFY | Not recorded | Not recorded | 2 | 0.80 | |
| ARBA00047230 YAML |
Assigns GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity to primate and eukaryotic myotubularin-family proteins through four alternative condition sets: the myotubularin-like phosphatase domain together with the protein-tyrosine phosphatase active site (Primates), and three myotubularin FunFams (Primates, Haplorrhini, Eukaryota). | GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity |
COMPLETE | ACCEPT | Not recorded | STRONG | 4 | 0.85 |
| ARBA00047239 YAML |
Assigns GO:0032206 positive regulation of telomere maintenance through eight alternative condition sets of CATH FunFams, most with a taxon condition: TRF2 (Mammalia), ATM (Eukaryota), tankyrase (Primates), MAPK1/MAPK3 (Haplorrhini), T-complex protein 1 subunit eta (Catarrhini), RTEL1, RuvB-like helicase (Mus) and SLX4 (Metazoa). | GO:0032206 positive regulation of telomere maintenance |
COMPLETE | ACCEPT | Not recorded | STRONG | 8 | 0.80 |
| ARBA00047244 YAML |
ARBA rule that assigned GO:0043605 amide catabolic process through four condition sets: urease signatures, PM20D1 FunFams in Eukaryota, ureide-pathway hydrolase FunFams in Viridiplantae, and an (S)-ureidoglycine aminohydrolase FunFam in Streptophyta. UniProt no longer serves the rule and the GO term is obsolete. | GO:0043605 obsolete amide catabolic process |
COMPLETE | DEPRECATE | Not recorded | Not recorded | 4 | 0.90 |
| ARBA00049204 YAML |
Assigns the superoxide dismutase reaction 2 superoxide + 2 H(+) = H2O2 + O2 (RHEA:20696, EC 1.15.1.1) through 23 alternative condition sets. Sets 1 and 3 to 8 and the FunFams of superfamilies 1.10.287.990 and 3.55.40.20 identify iron/manganese superoxide dismutases; set 2 and the FunFams of superfamily 2.60.40.200 identify copper/zinc superoxide dismutases. Most sets carry a taxon condition. | COMPLETE | ACCEPT | Not recorded | Not recorded | 23 | 0.85 | |
| ARBA00052213 YAML |
Assigns 3-oxopropanoate + NADP(+) + CoA = malonyl-CoA + NADPH + H(+) (EC 1.2.1.75) to archaeal proteins matching CATH FunFam 3.40.50.720:FF:000411. The FunFam contains both malonyl-CoA reductases and their aspartate-semialdehyde dehydrogenase paralogs, and the rule has no condition that separates them. | COMPLETE | MODIFY | ACCEPTABLE | MODERATE | 1 | 0.50 | |
| ARBA00067001 YAML |
Assigns EC 1.2.1.75 in the recommended name (displayed as "malonyl CoA reductase (malonate semialdehyde-forming)") to archaeal proteins matching CATH FunFam 3.40.50.720:FF:000411. The FunFam contains both malonyl-CoA reductases and their aspartate-semialdehyde dehydrogenase paralogs, and the rule has no condition that separates them. | COMPLETE | MODIFY | ACCEPTABLE | MODERATE | 1 | 0.50 | |
| ARBA00085337 YAML |
Assigns GO:0045454 (cell redox homeostasis) through 14 alternative condition sets, each one to three CATH FunFams with a taxon. The sets cover nitric oxide synthases in Primates, fungal and plant thioredoxins, peroxiredoxins, glutathione reductase, KRIT1, selenide water dikinase 1, the yeast mitochondrial porin and fungal SCO1-like proteins. | GO:0045454 cell redox homeostasis |
COMPLETE | ACCEPT | Not recorded | Not recorded | 14 | 0.70 |
| ARBA00085883 YAML |
Assigns GO:0030167 proteoglycan catabolic process through four alternative condition sets of CATH FunFams: beta-galactosidase (Euarchontoglires), alpha-L-iduronidase (no taxon condition), beta-hexosaminidase (Mus) and N-acetylglucosamine-6-sulfatase (Eukaryota). | GO:0030167 proteoglycan catabolic process |
COMPLETE | ACCEPT | Not recorded | STRONG | 4 | 0.80 |
| ARBA00086620 YAML |
Assigns GO:0043935 (sexual sporulation resulting in formation of a cellular spore) through four alternative condition sets, each a CATH FunFam with a taxon restriction: 14-3-3 proteins in Saccharomycetes, a syntaxin FunFam in Saccharomycetales, a chitin deacetylase FunFam in Eukaryota excluding Dictyostelia, and the sporulation protein kinase mde3 FunFam in Fungi. | GO:0043935 sexual sporulation resulting in formation of a cellular spore |
COMPLETE | ACCEPT | Not recorded | Not recorded | 4 | 0.75 |
| ARBA00087037 YAML |
Assigns GO:0005608 (laminin-121 trimer) through two condition sets, each a conjunction of three CATH FunFams with fungi excluded. Set 1 matches laminin subunit beta-2 and set 2 matches laminin subunit gamma-1. | GO:0005608 laminin-121 trimer |
COMPLETE | ACCEPT | Not recorded | Not recorded | 2 | 0.70 |
| ARBA00088058 YAML |
Assigns GO:0051010 (microtubule plus-end binding) through five condition sets: CLIP1/CLIP2 CAP-Gly FunFams in Glires, EB1 (MAPRE1) FunFams in Eukaryota, CLASP1/CLASP2 FunFams in Primates, the fungal EB FunFam (BIM1, mal3) and the CKAP5 FunFam in Dikarya (alp14, dis1). | GO:0051010 microtubule plus-end binding |
COMPLETE | ACCEPT | Not recorded | Not recorded | 5 | 0.85 |
| ARBA00088072 YAML |
Withdrawn ARBA rule. UniProt no longer serves it, and its condition sets were never recorded in this repository. It is reported to have assigned GO:0160103 tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity. | GO:0160103 tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity |
COMPLETE | DEPRECATE | Not recorded | Not recorded | 0 | 0.95 |
| ARBA00089174 YAML |
Assigns GO:1990845 (adaptive thermogenesis) to Mus proteins that match both CATH FunFams 1.10.287.70:FF:000074 and 1.25.40.20:FF:000018, which are named for transient receptor potential cation channel subfamily V member 1. | GO:1990845 adaptive thermogenesis |
COMPLETE | ACCEPT | Not recorded | Not recorded | 1 | 0.75 |
| ARBA00089175 YAML |
ARBA rule assigning GO:1990849 vacuolar localization to eukaryotic proteins that carry two CATH FunFams named for pleckstrin homology domain-containing family M member 1 (PLEKHM1). | GO:1990849 vacuolar localization |
COMPLETE | MODIFY | ACCEPTABLE | STRONG | 1 | 0.70 |
| ARBA00089176 YAML |
ARBA rule assigning GO:1990840 response to lectin through two condition sets: two PAK-family kinase FunFams in Primates, and two p300/CBP FunFams in Catarrhini. | GO:1990840 response to lectin |
COMPLETE | ACCEPT | Not recorded | MODERATE | 2 | 0.60 |
| ARBA00089180 YAML |
Assigns GO:1990858 cellular response to lectin through two alternative condition sets of CATH FunFams with a taxon: a pair of FunFams that together select group I p21-activated kinases (PAK1, PAK2, PAK3) in Primates, and a pair that selects CREBBP and EP300 in Catarrhini. | GO:1990858 cellular response to lectin |
COMPLETE | MODIFY | Not recorded | WEAK | 2 | 0.60 |
| ARBA00089391 YAML |
Assigns GO:1903711 (spermidine transmembrane transport) to fungal proteins in CATH FunFam 1.20.1730.10:FF:000006 (Urea active transporter), the family of the DUR3 polyamine and urea transporter. | GO:1903711 spermidine transmembrane transport |
COMPLETE | ACCEPT | Not recorded | MODERATE | 1 | 0.75 |
| ARBA00089395 YAML |
A withdrawn rule. As recorded before withdrawal it had one condition set, CATH FunFam 1.20.1250.20:FF:000011 in Taphrinomycotina, and the earlier analysis of it recorded the consequent as GO:1903710 spermine transmembrane transport. | COMPLETE | DEPRECATE | Not recorded | Not recorded | 1 | 0.90 | |
| ARBA00090047 YAML |
Withdrawn rule. As last recorded it assigned GO:1904498 (protein localization to mitotic actomyosin contractile ring) to Taphrinomycotina proteins in CATH FunFam 1.20.58.2220:FF:000006 (Cytokinesis protein sepA), the family of S. pombe for3 (Formin-3) and cdc12. | GO:1904498 protein localization to mitotic actomyosin contractile ring |
COMPLETE | DEPRECATE | Not recorded | Not recorded | 1 | 0.90 |
| ARBA00090252 YAML |
Assigns GO:0000055 (ribosomal large subunit export from nucleus) to two groups of budding-yeast ribosomal proteins: ubiquitin-ribosomal protein eL40 fusions in Saccharomycotina, and ribosomal protein uL1 (L10a) in Saccharomycetes. Each condition set requires two CATH FunFams and a taxon. | GO:0000055 ribosomal large subunit export from nucleus |
IN_PROGRESS | UNDECIDED | Not recorded | Not recorded | 2 | Not recorded |
| ARBA00090718 YAML |
Assigns GO:0047545 ((S)-2-hydroxyglutarate dehydrogenase activity) to proteins that have the FAD dependent oxidoreductase domain (IPR006076), the FAD/NAD(P)-binding domain superfamily (IPR036188) and membership of PANTHER family PTHR43104 (L-2-hydroxyglutarate dehydrogenase, mitochondrial). | GO:0047545 (S)-2-hydroxyglutarate dehydrogenase activity |
COMPLETE | ACCEPT | Not recorded | Not recorded | 1 | 0.85 |
| ARBA00092121 YAML |
ARBA rule that assigned GO:1903833 positive regulation of cellular response to amino acid starvation to fungal proteins in CATH FunFam 3.10.20.30:FF:000003 (Developmentally-regulated GTP-binding protein 1). UniProt no longer serves the rule. | GO:1903833 positive regulation of cellular response to amino acid starvation |
COMPLETE | DEPRECATE | Not recorded | Not recorded | 1 | 0.90 |
| ARBA00095398 YAML |
Assigns GO:0034517 (ribophagy) to Saccharomycotina proteins that match both 60S ribosomal protein L12 (uL11) CATH FunFams, 1.10.10.250:FF:000002 and 3.30.1550.10:FF:000002. | GO:0034517 ribophagy |
COMPLETE | ACCEPT | Not recorded | MODERATE | 1 | 0.60 |
Generated from cached review YAML by just rules-index.