|
ARBA00026249
|
Rule predicting thioredoxin-disulfide reductase (NADPH) activity based on InterPro domains and CATH FunFam classifications. The rule uses three alternative condition sets targeting the same enzymatic function. |
GO:0004791 (thioredoxin-disulfide reductase (NADPH) activity)
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MODIFY
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ACCEPTABLE
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STRONG
|
3 |
0.92 |
|
ARBA00047244
|
Rule predicting amide catabolic process (GO:0043605) based on four condition sets: (1) urease domains (beta/gamma subunits and active site) across all organisms, (2) PM20D1 FunFams in Eukaryota, (3) ureide pathway hydrolases in Viridiplantae, and (4) (S)-ureidoglycine aminohydrolase in Streptophyta. The rule captures mechanistically diverse enzymes that share the common chemistry of amide bond hydrolysis but serve distinct biological functions. |
GO:0043605 (amide catabolic process)
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DEPRECATE
|
OVERLY_COMPLEX
|
STRONG
|
4 |
0.80 |
|
ARBA00085883
|
Rule predicting proteoglycan catabolic process (GO:0030167) based on four condition sets: (1) beta-galactosidase in Eukaryota, (2) alpha-L-iduronidase, (3) beta-hexosaminidase in Mus, and (4) N-acetylglucosamine-6-sulfatase in Metazoa. These enzymes are lysosomal hydrolases involved in sequential degradation of glycosaminoglycan (GAG) chains that constitute proteoglycans. However, beta-galactosidase and beta-hexosaminidase are primarily known for ganglioside degradation, raising questions about annotation specificity. |
GO:0030167 (proteoglycan catabolic process)
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MODIFY
|
REDUNDANT
|
STRONG
|
4 |
0.60 |
|
ARBA00089174
|
Rule predicting adaptive thermogenesis (GO:1990845) based on two alternative condition sets: PM20D1 FunFams in Eukaryota, and TRPV1 FunFams in Mus. The rule captures two mechanistically distinct pathways to thermogenic regulation. |
GO:1990845 (adaptive thermogenesis)
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MODIFY
|
REDUNDANT
|
STRONG
|
2 |
0.85 |