SQSTM1

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0035973 aggrephagy	IBA GO_REF:0000033	ACCEPT	Summary: Phylogenetic inference of aggrephagy, the core p62 process - selective autophagic clearance of ubiquitinated protein aggregates. Strongly corroborated by direct experimental evidence. Reason: Core biological process for p62; abundant IDA support (e.g. PMID:17580304, PMID:22017874) confirms the phylogenetic inference. Supporting Evidence: PMID:17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated
GO:0000423 mitophagy	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Phylogenetic inference of involvement in mitophagy. p62 is recruited to depolarized mitochondria and drives their perinuclear clustering but is dispensable for the clearance step itself. Reason: Real but secondary/supporting role; p62 is required for Parkin-induced mitochondrial clustering but not for mitochondrial clearance (PMID:20890124), so mitophagy is non-core relative to general aggrephagy/selective autophagy. Supporting Evidence: PMID:20890124 p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy
GO:0005080 protein kinase C binding	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Phylogenetic inference of protein kinase C binding, reflecting the well-documented PB1-mediated interaction of p62 with atypical PKCs (PRKCZ/PRKCI). Reason: Genuine interaction underlying the NF-kB signaling scaffold role, but secondary to the core autophagy-receptor function.
GO:0007032 endosome organization	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Phylogenetic inference of a role in endosome organization, consistent with the experimentally demonstrated function of ubiquitinated p62 as a perinuclear molecular bridge retaining endosomal vesicles. Reason: Experimentally supported (PMID:27368102) but a specialized, secondary role distinct from the core selective-autophagy receptor function.
GO:0044753 amphisome	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Phylogenetic inference that p62 acts in the amphisome, the hybrid organelle formed by autophagosome-endosome fusion along the autophagic pathway. Reason: Plausible transit compartment along the autophagy pathway (IDA support in PMID:19640926) but a non-core sub-localization.
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding	IBA GO_REF:0000033	ACCEPT	Summary: Phylogenetic inference of K63-linked polyubiquitin binding, the core molecular activity of the p62 UBA domain that recognizes ubiquitinated cargo. Reason: Core molecular function; the UBA domain preferentially binds K63-linked polyubiquitin (PMID:12857745), supported by direct experimental evidence.
GO:0016235 aggresome	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: Phylogenetic inference that p62 acts in the aggresome, the perinuclear inclusion where misfolded ubiquitinated proteins are concentrated prior to autophagic clearance. Reason: p62 is a common constituent of aggresomes/inclusion bodies, but this reflects the cargo-sequestration outcome rather than a distinct core compartment.
GO:0000407 phagophore assembly site	IEA GO_REF:0000120	ACCEPT	Summary: Electronic prediction of localization to the phagophore assembly site (PAS), where p62 nucleates ubiquitin condensates that initiate autophagosome formation. Reason: Consistent with the EXP-supported PAS localization (PMID:34471133) and the core role of p62 condensates in autophagy initiation.
GO:0005634 nucleus	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Electronic transfer of nuclear localization from the UniProt subcellular location. p62 shuttles to the nucleus and is found in PML bodies, recruiting ubiquitinated proteins there. Reason: Real but secondary localization (also EXP-supported, PMID:10708586); the dominant functional pool is cytoplasmic.
GO:0005764 lysosome	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Electronic transfer of lysosomal localization, consistent with p62 trafficking to lysosomes as a degraded autophagic cargo. Reason: Reflects the endpoint of autophagic delivery rather than a core site of action; non-core localization.
GO:0005770 late endosome	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Electronic transfer of late endosome localization, consistent with the aPKC/endosome-trafficking role of p62. Reason: Experimentally supported (PMID:9566925, PMID:12471037) but a secondary compartment relative to the core cytoplasmic/autophagic function.
GO:0005776 autophagosome	IEA GO_REF:0000120	ACCEPT	Summary: Electronic prediction of autophagosome localization, the core site where p62 delivers ubiquitinated cargo via LIR-ATG8 binding. Reason: Core localization, strongly supported by IDA evidence (e.g. PMID:17580304, PMID:37802024).
GO:0005783 endoplasmic reticulum	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Electronic transfer of ER localization, consistent with p62 functioning near ER membranes (e.g. with TRIM13 in ER-stress autophagy). Reason: Context-specific, secondary localization (PMID:22178386); not the core site of action.
GO:0005829 cytosol	IEA GO_REF:0000044	ACCEPT	Summary: Electronic transfer of cytosolic localization, the principal compartment where p62 oligomerizes, binds cargo and forms condensates. Reason: Core localization; redundant with abundant IDA/TAS cytosol annotations.
GO:0008270 zinc ion binding	IEA GO_REF:0000002	KEEP AS NON CORE	Summary: InterPro-based prediction of zinc ion binding via the ZZ-type zinc finger, which coordinates Zn(2+) and mediates RIPK1 binding. Reason: Correct structural metal-binding activity of the ZZ domain, but ancillary to the core ubiquitin-reader/adaptor function rather than a standalone core MF.
GO:0016234 inclusion body	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: ARBA machine-learning prediction of inclusion body localization, consistent with p62 being a hallmark constituent of cytoplasmic ubiquitin-positive inclusions. Reason: Real (p62 bodies/inclusions) but represents the cargo-sequestration outcome; non-core compartment.
GO:0016605 PML body	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Electronic transfer of PML body localization, consistent with p62 recruiting ubiquitinated proteins to nuclear PML bodies. Reason: Experimentally supported nuclear sub-localization (PMID:20168092) but a secondary site relative to cytoplasmic function.
GO:0030017 sarcomere	IEA GO_REF:0000044	KEEP AS NON CORE	Summary: Electronic transfer of sarcomere localization, reflecting p62 interactions with muscle proteins (titin/TTN, FHOD3, TRIM55). Reason: Tissue-specific peripheral localization; not a core compartment for the autophagy-receptor function.
GO:0031399 regulation of protein modification process	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: ARBA machine-learning prediction of involvement in regulation of protein modification, a very broad parent term. Reason: Overly generic; p62's specific roles (e.g. regulating TRAF6 ubiquitination, KEAP1-mediated ubiquitination) are better captured by more precise terms.
GO:0005515 protein binding	IPI PMID:14676191 Comprehensive proteomic analysis of human Par protein comple...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:16169070 A human protein-protein interaction network: a resource for ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:16874300 The signaling adapter p62 is an important mediator of T help...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:17389358 Unc-51-like kinase 1/2-mediated endocytic processes regulate...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:18083104 Homeostatic levels of p62 control cytoplasmic inclusion body...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:19229298 Protein quality control during aging involves recruitment of...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:19250911 A role for NBR1 in autophagosomal degradation of ubiquitinat...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:19427866 Interactions with LC3 and polyubiquitin chains link nbr1 to ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:19615732 Defining the human deubiquitinating enzyme interaction lands...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:20010802 Nix is a selective autophagy receptor for mitochondrial clea...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:20168092 p62/SQSTM1 and ALFY interact to facilitate the formation of ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:20173742 The selective autophagy substrate p62 activates the stress r...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:20417604 The selective macroautophagic degradation of aggregated prot...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:20452972 p62/SQSTM1 is a target gene for transcription factor NRF2 an...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:20551902 CIN85 regulates dopamine receptor endocytosis and governs be...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:20562859 Network organization of the human autophagy system.	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:20808283 NBR1 is a new PB1 signalling adapter in Th2 differentiation ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:21149568 Formin follows function: a muscle-specific isoform of FHOD3 ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:21900206 A directed protein interaction network for investigating int...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:21988832 Toward an understanding of the protein interaction network o...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:22190034 Global landscape of HIV-human protein complexes.	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:23274085 Sestrins activate Nrf2 by promoting p62-dependent autophagic...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:23459205 Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:24089205 Autophagy promotes primary ciliogenesis by removing OFD1 fro...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:24316673 Autophagy variation within a cell population determines cell...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:24668264 Structural determinants in GABARAP required for the selectiv...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:24879152 Phosphorylation of NBR1 by GSK3 modulates protein aggregatio...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:25026213 Ubiquitylation of autophagy receptor Optineurin by HACE1 act...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:25040165 Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylat...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:25686248 Huntingtin functions as a scaffold for selective macroautoph...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:25910212 Widespread macromolecular interaction perturbations in human...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:25959826 Quantitative interaction proteomics of neurodegenerative dis...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:26344566 ATM functions at the peroxisome to induce pexophagy in respo...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:26524528 Autophagy mediates degradation of nuclear lamina.	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:26637326 ENC1 Modulates the Aggregation and Neurotoxicity of Mutant H...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:27728806 p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:29519959 P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) s...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:31169361 A Case Study on the Keap1 Interaction with Peptide Sequence ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:31616248 Systematic Affinity Purification Coupled to Mass Spectrometr...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:32296183 A reference map of the human binary protein interactome.	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:33436498 Cytoplasmic short linear motifs in ACE2 and integrin β(3) li...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:34524948 Global Proximity Interactome of the Human Macroautophagy Pat...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:34591642 A protein network map of head and neck cancer reveals PIK3CA...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:34799561 Large scale discovery of coronavirus-host factor protein int...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:35044719 Proteome-scale mapping of binding sites in the unstructured ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:35266954 The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its loc...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:37219487 Large-scale phosphomimetic screening identifies phospho-modu...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:37460613 P62/SQSTM1 binds with claudin-2 to target for selective auto...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:39009827 Proteome-scale characterisation of motif-based interactome r...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:8702753 p62, a phosphotyrosine-independent ligand of the SH2 domain ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0042802 identical protein binding	IPI PMID:16169070 A human protein-protein interaction network: a resource for ...	KEEP AS NON CORE	Summary: Reflects PB1-domain-mediated homo-oligomerization of p62 into filament-like arrays, a genuine self-association. Reason: Self-association via the PB1 domain is real and underlies condensate formation, but is ancillary to the core ubiquitin-reader/adaptor function; retained as non-core.
GO:0042802 identical protein binding	IPI PMID:20562859 Network organization of the human autophagy system.	KEEP AS NON CORE	Summary: Reflects PB1-domain-mediated homo-oligomerization of p62 into filament-like arrays, a genuine self-association. Reason: Self-association via the PB1 domain is real and underlies condensate formation, but is ancillary to the core ubiquitin-reader/adaptor function; retained as non-core.
GO:0042802 identical protein binding	IPI PMID:21900206 A directed protein interaction network for investigating int...	KEEP AS NON CORE	Summary: Reflects PB1-domain-mediated homo-oligomerization of p62 into filament-like arrays, a genuine self-association. Reason: Self-association via the PB1 domain is real and underlies condensate formation, but is ancillary to the core ubiquitin-reader/adaptor function; retained as non-core.
GO:0042802 identical protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	KEEP AS NON CORE	Summary: Reflects PB1-domain-mediated homo-oligomerization of p62 into filament-like arrays, a genuine self-association. Reason: Self-association via the PB1 domain is real and underlies condensate formation, but is ancillary to the core ubiquitin-reader/adaptor function; retained as non-core.
GO:0042802 identical protein binding	IPI PMID:25686248 Huntingtin functions as a scaffold for selective macroautoph...	KEEP AS NON CORE	Summary: Reflects PB1-domain-mediated homo-oligomerization of p62 into filament-like arrays, a genuine self-association. Reason: Self-association via the PB1 domain is real and underlies condensate formation, but is ancillary to the core ubiquitin-reader/adaptor function; retained as non-core.
GO:0042802 identical protein binding	IPI PMID:32296183 A reference map of the human binary protein interactome.	KEEP AS NON CORE	Summary: Reflects PB1-domain-mediated homo-oligomerization of p62 into filament-like arrays, a genuine self-association. Reason: Self-association via the PB1 domain is real and underlies condensate formation, but is ancillary to the core ubiquitin-reader/adaptor function; retained as non-core.
GO:0001659 temperature homeostasis	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer (Ensembl Compara) prediction of involvement in temperature homeostasis from mouse. Reason: Pleiotropic, mouse-derived peripheral process; biologically plausible but not a core p62 function.
GO:0002931 response to ischemia	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of involvement in response to ischemia. Reason: Peripheral mouse-derived process; retained as non-core.
GO:0005080 protein kinase C binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Protein kinase C binding via the PB1 domain (atypical PKCs PRKCZ/PRKCI). Reason: Genuine interaction underlying the NF-kB scaffold role; secondary to the core autophagy-receptor function.
GO:0005739 mitochondrion	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of mitochondrial localization, consistent with recruitment to damaged mitochondria during mitophagy. Reason: Real in the mitophagy context but a secondary, condition-dependent localization; non-core.
GO:0006606 protein import into nucleus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of involvement in protein import into nucleus. Reason: Peripheral, indirectly related to nuclear shuttling; non-core.
GO:0006914 autophagy	IEA GO_REF:0000107	ACCEPT	Summary: Involvement in autophagy, the overarching process in which p62 functions as a selective receptor. Reason: Core process; supported by IMP/IDA evidence.
GO:0016235 aggresome	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of aggresome localization. Reason: Real (p62 is an aggresome constituent) but reflects sequestration outcome; non-core.
GO:0030674 protein-macromolecule adaptor activity	IEA GO_REF:0000107	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0031397 negative regulation of protein ubiquitination	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Direct evidence that p62 negatively regulates protein ubiquitination in specific contexts (e.g. via KEAP1 sequestration / TRAF6 modulation). Reason: Real regulatory effect but context-specific; non-core.
GO:0035255 ionotropic glutamate receptor binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer/ISS prediction of ionotropic glutamate receptor binding (synaptic context). Reason: Peripheral, neuron-specific interaction; non-core.
GO:0035973 aggrephagy	IEA GO_REF:0000107	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0042802 identical protein binding	IEA GO_REF:0000120	KEEP AS NON CORE	Summary: Reflects PB1-domain-mediated homo-oligomerization of p62 into filament-like arrays, a genuine self-association. Reason: Self-association via the PB1 domain is real and underlies condensate formation, but is ancillary to the core ubiquitin-reader/adaptor function; retained as non-core.
GO:0044754 autolysosome	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Autolysosome localization, the degradative endpoint of the autophagic pathway. Reason: Endpoint compartment; non-core.
GO:0044877 protein-containing complex binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of protein-containing complex binding. Reason: Generic binding term; non-core.
GO:0045202 synapse	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of activity at the synapse. Reason: Neuron-specific peripheral localization; non-core.
GO:0070342 brown fat cell proliferation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of involvement in brown fat cell proliferation (mouse metabolic phenotype). Reason: Tissue/metabolic pleiotropy from mouse; non-core.
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding	IEA GO_REF:0000107	ACCEPT	Summary: Direct evidence that p62 binds K63-linked polyubiquitin via its UBA domain - the chain-type preference central to cargo recognition. Reason: Core molecular function for selective autophagy.
GO:0097009 energy homeostasis	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of involvement in energy homeostasis (mouse metabolic phenotype). Reason: Metabolic pleiotropy from mouse; non-core.
GO:0097225 sperm midpiece	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of sperm midpiece localization. Reason: Tissue-specific peripheral localization; non-core.
GO:0097413 Lewy body	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of Lewy body localization, consistent with p62 being a constituent of these inclusions. Reason: Disease-inclusion localization (sequestration outcome); non-core.
GO:0098978 glutamatergic synapse	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer prediction of activity at the glutamatergic synapse. Reason: Neuron-specific peripheral localization; non-core.
GO:0140036 ubiquitin-modified protein reader activity	IEA GO_REF:0000107	ACCEPT	Summary: Direct evidence that p62 acts as a ubiquitin-modified protein reader, recognizing ubiquitinated cargo. Reason: Core molecular function of the selective autophagy receptor.
GO:0140693 molecular condensate scaffold activity	IEA GO_REF:0000107	ACCEPT	Summary: Direct evidence that p62 acts as a molecular condensate scaffold, driving phase separation into p62 bodies. Reason: Core molecular function enabling cargo concentration for autophagy.
GO:0140694 membraneless organelle assembly	IEA GO_REF:0000107	ACCEPT	Summary: Direct evidence that p62 drives assembly of membraneless organelles (p62 bodies) via phase separation. Reason: Core process underlying selective sequestration of ubiquitinated cargo.
GO:1900273 positive regulation of long-term synaptic potentiation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer/ISS prediction of positive regulation of long-term synaptic potentiation. Reason: Neuron-specific peripheral process; non-core.
GO:1903078 positive regulation of protein localization to plasma membrane	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: Ortholog-transfer/ISS prediction of positive regulation of protein localization to plasma membrane. Reason: Peripheral process; non-core.
GO:0043065 positive regulation of apoptotic process	TAS Reactome:R-HSA-205043	KEEP AS NON CORE	Summary: Reactome curation linking p62 to positive regulation of apoptosis in the NRIF death-signaling pathway. Reason: Indirect, context-specific; non-core.
GO:0036464 cytoplasmic ribonucleoprotein granule	IDA PMID:20357094 p62/sequestosome-1 associates with and sustains the expressi...	KEEP AS NON CORE	Summary: Localization to cytoplasmic ribonucleoprotein granules (TRIM5alpha/stress-granule-associated context). Reason: Context-specific condensate localization; non-core.
GO:0005829 cytosol	IDA GO_REF:0000052	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0000407 phagophore assembly site	EXP PMID:34471133 Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in...	ACCEPT	Summary: Experimental localization to the phagophore assembly site, where p62 condensates nucleate autophagosome formation. Reason: Core localization for autophagy initiation; supported by reconstitution/EXP evidence (PMID:34471133).
GO:0005634 nucleus	EXP PMID:10708586 p62 functions as a p38 MAP kinase regulator.	KEEP AS NON CORE	Summary: Experimental nuclear localization; p62 shuttles to the nucleus and PML bodies. Reason: Real but secondary localization (PMID:10708586); dominant pool is cytoplasmic.
GO:0005764 lysosome	EXP PMID:9566925 Localization of atypical protein kinase C isoforms into lyso...	KEEP AS NON CORE	Summary: Experimental lysosomal localization, consistent with p62 trafficking to lysosomes as autophagic cargo and via aPKC/endosome routes. Reason: Endpoint/secondary compartment; non-core.
GO:0005770 late endosome	EXP PMID:12471037 Association of the atypical protein kinase C-interacting pro...	KEEP AS NON CORE	Summary: Experimental late-endosome localization via the aPKC-interaction/endosome-trafficking role. Reason: Secondary compartment (PMID:9566925, PMID:12471037); non-core.
GO:0005770 late endosome	EXP PMID:9566925 Localization of atypical protein kinase C isoforms into lyso...	KEEP AS NON CORE	Summary: Experimental late-endosome localization via the aPKC-interaction/endosome-trafficking role. Reason: Secondary compartment (PMID:9566925, PMID:12471037); non-core.
GO:0005783 endoplasmic reticulum	EXP PMID:22178386 TRIM13 regulates ER stress induced autophagy and clonogenic ...	KEEP AS NON CORE	Summary: Experimental ER localization in ER-stress autophagy contexts. Reason: Context-specific secondary localization (PMID:22178386); non-core.
GO:0033554 cellular response to stress	IDA PMID:37802024 S-acylation of p62 promotes p62 droplet recruitment into aut...	ACCEPT	Summary: Direct evidence that p62 participates in the cellular stress response (e.g. oxidative/proteotoxic stress, NRF2 activation). Reason: Genuine core-adjacent stress-response involvement directly demonstrated; underlies p62's cytoprotective KEAP1-NRF2 and proteostasis functions.
GO:0016236 macroautophagy	IMP PMID:22622177 The deubiquitinating enzyme USP36 controls selective autopha...	ACCEPT	Summary: Direct/mutant-phenotype evidence that p62 functions in macroautophagy as a selective cargo receptor. Reason: Core biological process; strongly supported across multiple IDA/IMP studies.
GO:0016236 macroautophagy	IDA PMID:27498865 TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p6...	ACCEPT	Summary: Direct/mutant-phenotype evidence that p62 functions in macroautophagy as a selective cargo receptor. Reason: Core biological process; strongly supported across multiple IDA/IMP studies.
GO:0030674 protein-macromolecule adaptor activity	IDA PMID:34893540 The N-terminal cysteine is a dual sensor of oxygen and oxida...	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0071211 protein targeting to vacuole involved in autophagy	IDA PMID:34893540 The N-terminal cysteine is a dual sensor of oxygen and oxida...	ACCEPT	Summary: Direct evidence that p62 targets proteins to the vacuole/lysosome via autophagy. Reason: Core: this is the cargo-delivery outcome of the p62 receptor function.
GO:0110076 negative regulation of ferroptosis	IMP PMID:26403645 Activation of the p62-Keap1-NRF2 pathway protects against fe...	KEEP AS NON CORE	Summary: Mutant-phenotype evidence that p62 negatively regulates ferroptosis via the KEAP1-NRF2 axis. Reason: Real cytoprotective effect downstream of NRF2 activation (PMID:26403645); a specialized secondary outcome, non-core.
GO:0140036 ubiquitin-modified protein reader activity	IDA PMID:34893540 The N-terminal cysteine is a dual sensor of oxygen and oxida...	ACCEPT	Summary: Direct evidence that p62 acts as a ubiquitin-modified protein reader, recognizing ubiquitinated cargo. Reason: Core molecular function of the selective autophagy receptor.
GO:0005776 autophagosome	IDA PMID:37802024 S-acylation of p62 promotes p62 droplet recruitment into aut...	ACCEPT	Summary: Autophagosome localization, the core organelle where p62 delivers and is degraded with ubiquitinated cargo via LIR-ATG8 binding. Reason: Core site of action; directly demonstrated across multiple IDA studies (e.g. PMID:17580304, PMID:37802024).
GO:0005829 cytosol	IDA PMID:29343546 p62 filaments capture and present ubiquitinated cargos for a...	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	IDA PMID:29507397 Polyubiquitin chain-induced p62 phase separation drives auto...	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	IDA PMID:37306101 Phosphorylation of phase-separated p62 bodies by ULK1 activa...	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0030674 protein-macromolecule adaptor activity	IDA PMID:31857589 Requirement for p62 acetylation in the aggregation of ubiqui...	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0030674 protein-macromolecule adaptor activity	IDA PMID:37802024 S-acylation of p62 promotes p62 droplet recruitment into aut...	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0033554 cellular response to stress	IDA PMID:17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradat...	ACCEPT	Summary: Direct evidence that p62 participates in the cellular stress response (e.g. oxidative/proteotoxic stress, NRF2 activation). Reason: Genuine core-adjacent stress-response involvement directly demonstrated; underlies p62's cytoprotective KEAP1-NRF2 and proteostasis functions.
GO:0035973 aggrephagy	IDA PMID:17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradat...	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0035973 aggrephagy	IDA PMID:31857589 Requirement for p62 acetylation in the aggregation of ubiqui...	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0035973 aggrephagy	IDA PMID:37802024 S-acylation of p62 promotes p62 droplet recruitment into aut...	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0043232 intracellular membraneless organelle	IDA PMID:31857589 Requirement for p62 acetylation in the aggregation of ubiqui...	ACCEPT	Summary: Direct evidence that p62 is active within intracellular membraneless organelles (p62 bodies/condensates). Reason: Core: p62 bodies are the membraneless organelles through which p62 concentrates cargo.
GO:0043232 intracellular membraneless organelle	IDA PMID:37802024 S-acylation of p62 promotes p62 droplet recruitment into aut...	ACCEPT	Summary: Direct evidence that p62 is active within intracellular membraneless organelles (p62 bodies/condensates). Reason: Core: p62 bodies are the membraneless organelles through which p62 concentrates cargo.
GO:0071211 protein targeting to vacuole involved in autophagy	IDA PMID:37802024 S-acylation of p62 promotes p62 droplet recruitment into aut...	ACCEPT	Summary: Direct evidence that p62 targets proteins to the vacuole/lysosome via autophagy. Reason: Core: this is the cargo-delivery outcome of the p62 receptor function.
GO:0140036 ubiquitin-modified protein reader activity	IDA PMID:31857589 Requirement for p62 acetylation in the aggregation of ubiqui...	ACCEPT	Summary: Direct evidence that p62 acts as a ubiquitin-modified protein reader, recognizing ubiquitinated cargo. Reason: Core molecular function of the selective autophagy receptor.
GO:0140693 molecular condensate scaffold activity	IDA PMID:31857589 Requirement for p62 acetylation in the aggregation of ubiqui...	ACCEPT	Summary: Direct evidence that p62 acts as a molecular condensate scaffold, driving phase separation into p62 bodies. Reason: Core molecular function enabling cargo concentration for autophagy.
GO:0140693 molecular condensate scaffold activity	IDA PMID:37802024 S-acylation of p62 promotes p62 droplet recruitment into aut...	ACCEPT	Summary: Direct evidence that p62 acts as a molecular condensate scaffold, driving phase separation into p62 bodies. Reason: Core molecular function enabling cargo concentration for autophagy.
GO:0140694 membraneless organelle assembly	IDA PMID:31857589 Requirement for p62 acetylation in the aggregation of ubiqui...	ACCEPT	Summary: Direct evidence that p62 drives assembly of membraneless organelles (p62 bodies) via phase separation. Reason: Core process underlying selective sequestration of ubiquitinated cargo.
GO:0140694 membraneless organelle assembly	IDA PMID:37802024 S-acylation of p62 promotes p62 droplet recruitment into aut...	ACCEPT	Summary: Direct evidence that p62 drives assembly of membraneless organelles (p62 bodies) via phase separation. Reason: Core process underlying selective sequestration of ubiquitinated cargo.
GO:0035973 aggrephagy	IDA PMID:22017874 Serine 403 phosphorylation of p62/SQSTM1 regulates selective...	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0035973 aggrephagy	IDA PMID:29343546 p62 filaments capture and present ubiquitinated cargos for a...	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0035973 aggrephagy	IDA PMID:29507397 Polyubiquitin chain-induced p62 phase separation drives auto...	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0035973 aggrephagy	IDA PMID:37306101 Phosphorylation of phase-separated p62 bodies by ULK1 activa...	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0043232 intracellular membraneless organelle	IDA PMID:22017874 Serine 403 phosphorylation of p62/SQSTM1 regulates selective...	ACCEPT	Summary: Direct evidence that p62 is active within intracellular membraneless organelles (p62 bodies/condensates). Reason: Core: p62 bodies are the membraneless organelles through which p62 concentrates cargo.
GO:0043232 intracellular membraneless organelle	IDA PMID:29343546 p62 filaments capture and present ubiquitinated cargos for a...	ACCEPT	Summary: Direct evidence that p62 is active within intracellular membraneless organelles (p62 bodies/condensates). Reason: Core: p62 bodies are the membraneless organelles through which p62 concentrates cargo.
GO:0043232 intracellular membraneless organelle	IDA PMID:29507397 Polyubiquitin chain-induced p62 phase separation drives auto...	ACCEPT	Summary: Direct evidence that p62 is active within intracellular membraneless organelles (p62 bodies/condensates). Reason: Core: p62 bodies are the membraneless organelles through which p62 concentrates cargo.
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding	IDA PMID:29343546 p62 filaments capture and present ubiquitinated cargos for a...	ACCEPT	Summary: Direct evidence that p62 binds K63-linked polyubiquitin via its UBA domain - the chain-type preference central to cargo recognition. Reason: Core molecular function for selective autophagy.
GO:0140036 ubiquitin-modified protein reader activity	IDA PMID:22017874 Serine 403 phosphorylation of p62/SQSTM1 regulates selective...	ACCEPT	Summary: Direct evidence that p62 acts as a ubiquitin-modified protein reader, recognizing ubiquitinated cargo. Reason: Core molecular function of the selective autophagy receptor.
GO:0140311 protein sequestering activity	IDA PMID:37306101 Phosphorylation of phase-separated p62 bodies by ULK1 activa...	ACCEPT	Summary: Direct evidence that p62 sequesters target proteins (e.g. into condensates) to control their activity/localization. Reason: Core: protein sequestration into p62 bodies is central to its receptor and KEAP1-regulatory functions.
GO:0140693 molecular condensate scaffold activity	IDA PMID:29343546 p62 filaments capture and present ubiquitinated cargos for a...	ACCEPT	Summary: Direct evidence that p62 acts as a molecular condensate scaffold, driving phase separation into p62 bodies. Reason: Core molecular function enabling cargo concentration for autophagy.
GO:0140693 molecular condensate scaffold activity	IDA PMID:29507397 Polyubiquitin chain-induced p62 phase separation drives auto...	ACCEPT	Summary: Direct evidence that p62 acts as a molecular condensate scaffold, driving phase separation into p62 bodies. Reason: Core molecular function enabling cargo concentration for autophagy.
GO:0140693 molecular condensate scaffold activity	IDA PMID:37306101 Phosphorylation of phase-separated p62 bodies by ULK1 activa...	ACCEPT	Summary: Direct evidence that p62 acts as a molecular condensate scaffold, driving phase separation into p62 bodies. Reason: Core molecular function enabling cargo concentration for autophagy.
GO:0140694 membraneless organelle assembly	IDA PMID:29343546 p62 filaments capture and present ubiquitinated cargos for a...	ACCEPT	Summary: Direct evidence that p62 drives assembly of membraneless organelles (p62 bodies) via phase separation. Reason: Core process underlying selective sequestration of ubiquitinated cargo.
GO:0140694 membraneless organelle assembly	IDA PMID:29507397 Polyubiquitin chain-induced p62 phase separation drives auto...	ACCEPT	Summary: Direct evidence that p62 drives assembly of membraneless organelles (p62 bodies) via phase separation. Reason: Core process underlying selective sequestration of ubiquitinated cargo.
GO:0005737 cytoplasm	IC PMID:31281713 p62 Negatively Regulates TLR4 Signaling via Functional Regul...	ACCEPT	Summary: Cytoplasm is the principal compartment where p62 oligomerizes, binds cargo and forms condensates. Reason: Core localization.
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway	IDA PMID:31281713 p62 Negatively Regulates TLR4 Signaling via Functional Regul...	ACCEPT	Summary: Direct evidence that p62 negatively regulates TLR4 signaling by acting on the TRAF6-ECSIT complex. Reason: Specific, directly demonstrated immune-signaling function (PMID:31281713).
GO:0140313 molecular sequestering activity	IDA PMID:31281713 p62 Negatively Regulates TLR4 Signaling via Functional Regul...	KEEP AS NON CORE	Summary: Direct evidence of molecular sequestering activity (sequestration of the TRAF6-ECSIT complex to dampen TLR4 signaling). Reason: Genuine sequestration activity in a specific signaling context; the broader protein-sequestering term captures the core role, so non-core here.
GO:0016236 macroautophagy	IDA PMID:36221902 Selective autophagy of RIPosomes maintains innate immune hom...	ACCEPT	Summary: Direct/mutant-phenotype evidence that p62 functions in macroautophagy as a selective cargo receptor. Reason: Core biological process; strongly supported across multiple IDA/IMP studies.
GO:0030163 protein catabolic process	IDA PMID:36221902 Selective autophagy of RIPosomes maintains innate immune hom...	ACCEPT	Summary: Direct evidence that p62 drives catabolism of its cargo proteins via selective autophagy. Reason: Core outcome of the receptor function; directly demonstrated.
GO:0030674 protein-macromolecule adaptor activity	IDA PMID:36221902 Selective autophagy of RIPosomes maintains innate immune hom...	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0071211 protein targeting to vacuole involved in autophagy	IDA PMID:36221902 Selective autophagy of RIPosomes maintains innate immune hom...	ACCEPT	Summary: Direct evidence that p62 targets proteins to the vacuole/lysosome via autophagy. Reason: Core: this is the cargo-delivery outcome of the p62 receptor function.
GO:0140036 ubiquitin-modified protein reader activity	IDA PMID:36221902 Selective autophagy of RIPosomes maintains innate immune hom...	ACCEPT	Summary: Direct evidence that p62 acts as a ubiquitin-modified protein reader, recognizing ubiquitinated cargo. Reason: Core molecular function of the selective autophagy receptor.
GO:0005776 autophagosome	IDA PMID:30612879 The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammaso...	ACCEPT	Summary: Autophagosome localization, the core organelle where p62 delivers and is degraded with ubiquitinated cargo via LIR-ATG8 binding. Reason: Core site of action; directly demonstrated across multiple IDA studies (e.g. PMID:17580304, PMID:37802024).
GO:0016236 macroautophagy	IDA PMID:30612879 The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammaso...	ACCEPT	Summary: Direct/mutant-phenotype evidence that p62 functions in macroautophagy as a selective cargo receptor. Reason: Core biological process; strongly supported across multiple IDA/IMP studies.
GO:0016236 macroautophagy	IDA PMID:32715615 Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS ...	ACCEPT	Summary: Direct/mutant-phenotype evidence that p62 functions in macroautophagy as a selective cargo receptor. Reason: Core biological process; strongly supported across multiple IDA/IMP studies.
GO:0030163 protein catabolic process	IDA PMID:30612879 The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammaso...	ACCEPT	Summary: Direct evidence that p62 drives catabolism of its cargo proteins via selective autophagy. Reason: Core outcome of the receptor function; directly demonstrated.
GO:0030163 protein catabolic process	IDA PMID:32715615 Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS ...	ACCEPT	Summary: Direct evidence that p62 drives catabolism of its cargo proteins via selective autophagy. Reason: Core outcome of the receptor function; directly demonstrated.
GO:0030674 protein-macromolecule adaptor activity	IDA PMID:30612879 The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammaso...	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0030674 protein-macromolecule adaptor activity	IDA PMID:32715615 Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS ...	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0071211 protein targeting to vacuole involved in autophagy	IDA PMID:30612879 The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammaso...	ACCEPT	Summary: Direct evidence that p62 targets proteins to the vacuole/lysosome via autophagy. Reason: Core: this is the cargo-delivery outcome of the p62 receptor function.
GO:0071211 protein targeting to vacuole involved in autophagy	IDA PMID:32715615 Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS ...	ACCEPT	Summary: Direct evidence that p62 targets proteins to the vacuole/lysosome via autophagy. Reason: Core: this is the cargo-delivery outcome of the p62 receptor function.
GO:0030674 protein-macromolecule adaptor activity	IDA PMID:27498865 TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p6...	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0030163 protein catabolic process	IDA PMID:27498865 TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p6...	ACCEPT	Summary: Direct evidence that p62 drives catabolism of its cargo proteins via selective autophagy. Reason: Core outcome of the receptor function; directly demonstrated.
GO:0035591 signaling adaptor activity	IDA PMID:27498865 TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p6...	ACCEPT	Summary: Direct evidence that p62 acts as a signaling adaptor bringing together components of signaling pathways (e.g. NF-kB, selective autophagy of immune regulators). Reason: Core scaffolding/adaptor molecular function; directly demonstrated (PMID:27498865).
GO:0071211 protein targeting to vacuole involved in autophagy	IDA PMID:27498865 TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p6...	ACCEPT	Summary: Direct evidence that p62 targets proteins to the vacuole/lysosome via autophagy. Reason: Core: this is the cargo-delivery outcome of the p62 receptor function.
GO:0140036 ubiquitin-modified protein reader activity	IDA PMID:27498865 TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p6...	ACCEPT	Summary: Direct evidence that p62 acts as a ubiquitin-modified protein reader, recognizing ubiquitinated cargo. Reason: Core molecular function of the selective autophagy receptor.
GO:0005515 protein binding	IPI PMID:26458771 Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis thro...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0010508 positive regulation of autophagy	IDA PMID:28871090 TRIM23 mediates virus-induced autophagy via activation of TB...	ACCEPT	Summary: Direct evidence that p62 positively regulates autophagy (e.g. via TBK1/TRIM23 activation). Reason: Core-adjacent positive regulation of autophagy; directly demonstrated (PMID:28871090).
GO:0038023 signaling receptor activity	IDA PMID:28871090 TRIM23 mediates virus-induced autophagy via activation of TB...	KEEP AS NON CORE	Summary: p62 reported to act as a signaling receptor (TRIM23/TBK1 virus-induced autophagy). Reason: 'Signaling receptor activity' overstates p62's adaptor/scaffold role; the condensate-scaffold/adaptor terms are more accurate, so non-core.
GO:0000425 pexophagy	IDA PMID:26344566 ATM functions at the peroxisome to induce pexophagy in respo...	ACCEPT	Summary: Direct evidence that p62 mediates pexophagy by bridging ROS-induced ubiquitinated PEX5 to autophagosomes. Reason: Core selective-autophagy function applied to peroxisomes; directly demonstrated (PMID:26344566).
GO:0030674 protein-macromolecule adaptor activity	IDA PMID:26344566 ATM functions at the peroxisome to induce pexophagy in respo...	ACCEPT	Summary: Direct evidence that p62 acts as a protein-macromolecule adaptor bridging ubiquitinated cargo to the ATG8/autophagosome machinery. Reason: Core molecular function of p62 as a selective autophagy receptor.
GO:0005829 cytosol	TAS Reactome:R-HSA-9759169	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9759172	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9766532	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9766645	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9766656	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9766677	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9766687	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9759154	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005776 autophagosome	IDA PMID:25365221 Spastic paraplegia proteins spastizin and spatacsin mediate ...	ACCEPT	Summary: Autophagosome localization, the core organelle where p62 delivers and is degraded with ubiquitinated cargo via LIR-ATG8 binding. Reason: Core site of action; directly demonstrated across multiple IDA studies (e.g. PMID:17580304, PMID:37802024).
GO:0043130 ubiquitin binding	TAS Reactome:R-HSA-205008	ACCEPT	Summary: Direct evidence that p62 binds ubiquitin via its UBA domain. Reason: Core molecular function underlying cargo recognition.
GO:0005515 protein binding	IPI PMID:31006538 Intrinsically Disordered Protein TEX264 Mediates ER-phagy.	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0006914 autophagy	IDA PMID:20452972 p62/SQSTM1 is a target gene for transcription factor NRF2 an...	ACCEPT	Summary: Involvement in autophagy, the overarching process in which p62 functions as a selective receptor. Reason: Core process; supported by IMP/IDA evidence.
GO:0031397 negative regulation of protein ubiquitination	IDA PMID:20452972 p62/SQSTM1 is a target gene for transcription factor NRF2 an...	KEEP AS NON CORE	Summary: Direct evidence that p62 negatively regulates protein ubiquitination in specific contexts (e.g. via KEAP1 sequestration / TRAF6 modulation). Reason: Real regulatory effect but context-specific; non-core.
GO:0005776 autophagosome	IDA PMID:22948227 MAPK15/ERK8 stimulates autophagy by interacting with LC3 and...	ACCEPT	Summary: Autophagosome localization, the core organelle where p62 delivers and is degraded with ubiquitinated cargo via LIR-ATG8 binding. Reason: Core site of action; directly demonstrated across multiple IDA studies (e.g. PMID:17580304, PMID:37802024).
GO:0035973 aggrephagy	IPI PMID:28404643 The BEACH-containing protein WDR81 coordinates p62 and LC3C ...	ACCEPT	Summary: Direct evidence that p62 mediates aggrephagy - selective autophagic clearance of ubiquitinated protein aggregates. Reason: Core biological process; the defining selective-autophagy activity of p62.
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding	IDA PMID:28404643 The BEACH-containing protein WDR81 coordinates p62 and LC3C ...	ACCEPT	Summary: Direct evidence that p62 binds K63-linked polyubiquitin via its UBA domain - the chain-type preference central to cargo recognition. Reason: Core molecular function for selective autophagy.
GO:0005515 protein binding	IPI PMID:28404643 The BEACH-containing protein WDR81 coordinates p62 and LC3C ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0035255 ionotropic glutamate receptor binding	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: Ortholog-transfer/ISS prediction of ionotropic glutamate receptor binding (synaptic context). Reason: Peripheral, neuron-specific interaction; non-core.
GO:1900273 positive regulation of long-term synaptic potentiation	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: Ortholog-transfer/ISS prediction of positive regulation of long-term synaptic potentiation. Reason: Neuron-specific peripheral process; non-core.
GO:1903078 positive regulation of protein localization to plasma membrane	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: Ortholog-transfer/ISS prediction of positive regulation of protein localization to plasma membrane. Reason: Peripheral process; non-core.
GO:0005515 protein binding	IPI PMID:25422469 Disruption of FAT10-MAD2 binding inhibits tumor progression.	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005776 autophagosome	IDA PMID:24954904 WIPI2 links LC3 conjugation with PI3P, autophagosome formati...	ACCEPT	Summary: Autophagosome localization, the core organelle where p62 delivers and is degraded with ubiquitinated cargo via LIR-ATG8 binding. Reason: Core site of action; directly demonstrated across multiple IDA studies (e.g. PMID:17580304, PMID:37802024).
GO:0007032 endosome organization	IDA PMID:27368102 An ER-Associated Pathway Defines Endosomal Architecture for ...	KEEP AS NON CORE	Summary: Direct evidence that ubiquitinated p62 organizes endosomes as a perinuclear molecular bridge. Reason: Specialized secondary role (PMID:27368102); non-core relative to selective autophagy.
GO:0019899 enzyme binding	IPI PMID:27368102 An ER-Associated Pathway Defines Endosomal Architecture for ...	KEEP AS NON CORE	Summary: Enzyme binding (interaction with RNF26 ligase activity in endosome organization). Reason: Generic binding term; the specific adaptor/ubiquitin-ligase-binding roles are more informative.
GO:0031625 ubiquitin protein ligase binding	IDA PMID:27368102 An ER-Associated Pathway Defines Endosomal Architecture for ...	KEEP AS NON CORE	Summary: Ubiquitin protein ligase binding (interactions with TRIM E3 ligases and RNF26). Reason: Genuine interactions enabling selective autophagy of specific substrates; secondary to the core ubiquitin-reader function.
GO:0031625 ubiquitin protein ligase binding	IPI PMID:27368102 An ER-Associated Pathway Defines Endosomal Architecture for ...	KEEP AS NON CORE	Summary: Ubiquitin protein ligase binding (interactions with TRIM E3 ligases and RNF26). Reason: Genuine interactions enabling selective autophagy of specific substrates; secondary to the core ubiquitin-reader function.
GO:1905719 protein localization to perinuclear region of cytoplasm	IDA PMID:27368102 An ER-Associated Pathway Defines Endosomal Architecture for ...	KEEP AS NON CORE	Summary: Direct evidence that p62 promotes protein localization to the perinuclear region (endosome-organization role). Reason: Specialized secondary role (PMID:27368102); non-core.
GO:0016236 macroautophagy	IMP PMID:20168092 p62/SQSTM1 and ALFY interact to facilitate the formation of ...	ACCEPT	Summary: Direct/mutant-phenotype evidence that p62 functions in macroautophagy as a selective cargo receptor. Reason: Core biological process; strongly supported across multiple IDA/IMP studies.
GO:0000423 mitophagy	IGI PMID:20457763 Disease-causing mutations in parkin impair mitochondrial ubi...	KEEP AS NON CORE	Summary: Genetic-interaction evidence for involvement in mitophagy of depolarized mitochondria. Reason: Real but secondary role; p62 contributes to mitophagy (clustering) yet is dispensable for the clearance step (PMID:20890124).
GO:0098780 response to mitochondrial depolarisation	IGI PMID:20457763 Disease-causing mutations in parkin impair mitochondrial ubi...	KEEP AS NON CORE	Summary: Genetic-interaction evidence for involvement in response to mitochondrial depolarization (mitophagy context). Reason: Secondary mitophagy-associated process; non-core.
GO:0005515 protein binding	IPI PMID:27103069 Loss of C9ORF72 impairs autophagy and synergizes with polyQ ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005776 autophagosome	IDA PMID:19640926 LRRK2 regulates autophagic activity and localizes to specifi...	ACCEPT	Summary: Autophagosome localization, the core organelle where p62 delivers and is degraded with ubiquitinated cargo via LIR-ATG8 binding. Reason: Core site of action; directly demonstrated across multiple IDA studies (e.g. PMID:17580304, PMID:37802024).
GO:0044753 amphisome	IDA PMID:19640926 LRRK2 regulates autophagic activity and localizes to specifi...	KEEP AS NON CORE	Summary: Amphisome localization along the autophagy pathway (autophagosome-endosome fusion intermediate). Reason: Transit compartment (PMID:19640926); non-core.
GO:0044754 autolysosome	IDA PMID:19640926 LRRK2 regulates autophagic activity and localizes to specifi...	KEEP AS NON CORE	Summary: Autolysosome localization, the degradative endpoint of the autophagic pathway. Reason: Endpoint compartment; non-core.
GO:0005515 protein binding	IPI PMID:26347139 TRIM-mediated precision autophagy targets cytoplasmic regula...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:25126726 FLCN, a novel autophagy component, interacts with GABARAP an...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0031625 ubiquitin protein ligase binding	IPI PMID:25127057 TRIM proteins regulate autophagy and can target autophagic s...	KEEP AS NON CORE	Summary: Ubiquitin protein ligase binding (interactions with TRIM E3 ligases and RNF26). Reason: Genuine interactions enabling selective autophagy of specific substrates; secondary to the core ubiquitin-reader function.
GO:0061635 regulation of protein complex stability	IDA PMID:25127057 TRIM proteins regulate autophagy and can target autophagic s...	KEEP AS NON CORE	Summary: Direct evidence for regulation of protein complex stability (TRIM5 autophagy targeting context). Reason: Context-specific regulatory role; non-core.
GO:0010821 regulation of mitochondrion organization	NAS PMID:20890124 p62/SQSTM1 is required for Parkin-induced mitochondrial clus...	KEEP AS NON CORE	Summary: Author statement on regulation of mitochondrion organization (Parkin-induced clustering). Reason: Reflects the clustering role in mitophagy; secondary, non-core.
GO:0000422 autophagy of mitochondrion	NAS PMID:20098416 PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p6...	KEEP AS NON CORE	Summary: Author statement that p62 is involved in autophagy of mitochondrion (mitophagy). Reason: Supporting role in mitophagy; p62 mediates clustering of damaged mitochondria but is dispensable for clearance, so non-core.
GO:0005737 cytoplasm	IDA PMID:20168092 p62/SQSTM1 and ALFY interact to facilitate the formation of ...	ACCEPT	Summary: Cytoplasm is the principal compartment where p62 oligomerizes, binds cargo and forms condensates. Reason: Core localization.
GO:0005776 autophagosome	IDA PMID:20168092 p62/SQSTM1 and ALFY interact to facilitate the formation of ...	ACCEPT	Summary: Autophagosome localization, the core organelle where p62 delivers and is degraded with ubiquitinated cargo via LIR-ATG8 binding. Reason: Core site of action; directly demonstrated across multiple IDA studies (e.g. PMID:17580304, PMID:37802024).
GO:0016234 inclusion body	IDA PMID:20168092 p62/SQSTM1 and ALFY interact to facilitate the formation of ...	KEEP AS NON CORE	Summary: p62 localizes to inclusion bodies, the ubiquitin-positive cytoplasmic aggregates it helps form. Reason: Reflects cargo-sequestration outcome; non-core compartment.
GO:0016605 PML body	IDA PMID:20168092 p62/SQSTM1 and ALFY interact to facilitate the formation of ...	KEEP AS NON CORE	Summary: p62 localizes to nuclear PML bodies, recruiting ubiquitinated proteins there. Reason: Secondary nuclear sub-localization (PMID:20168092); non-core.
GO:0005829 cytosol	TAS Reactome:R-HSA-193641	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-193684	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-193694	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-193703	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-193705	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-204947	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-205008	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-209566	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-507719	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-5205649	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-5205663	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-5205673	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9664855	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9664880	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9664881	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9664892	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9759157	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9759158	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0005829 cytosol	TAS Reactome:R-HSA-9761900	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0070062 extracellular exosome	HDA PMID:19056867 Large-scale proteomics and phosphoproteomics of urinary exos...	KEEP AS NON CORE	Summary: High-throughput proteomic detection of p62 in urinary exosomes. Reason: Likely incidental detection in secreted vesicles; non-core localization.
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-204947	KEEP AS NON CORE	Summary: Reactome curation placing p62 in the nucleoplasm in the NRIF death-signaling context. Reason: Indirect/context-specific nuclear localization; non-core.
GO:0005515 protein binding	IPI PMID:20357094 p62/sequestosome-1 associates with and sustains the expressi...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradat...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005776 autophagosome	IDA PMID:17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradat...	ACCEPT	Summary: Autophagosome localization, the core organelle where p62 delivers and is degraded with ubiquitinated cargo via LIR-ATG8 binding. Reason: Core site of action; directly demonstrated across multiple IDA studies (e.g. PMID:17580304, PMID:37802024).
GO:0006914 autophagy	IMP PMID:17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradat...	ACCEPT	Summary: Involvement in autophagy, the overarching process in which p62 functions as a selective receptor. Reason: Core process; supported by IMP/IDA evidence.
GO:0005515 protein binding	IPI PMID:22178386 TRIM13 regulates ER stress induced autophagy and clonogenic ...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:22421968 TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-fa...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0005515 protein binding	IPI PMID:8618896 Phosphotyrosine-independent binding of a 62-kDa protein to t...	KEEP AS NON CORE	Summary: Records a physical interaction captured as bare 'protein binding'. Per curation guidelines this term is uninformative about the actual molecular function. Reason: Experimental interaction evidence (IPI) is retained, but bare protein binding does not describe a specific molecular function; the informative activities are captured by ubiquitin-reader/adaptor/condensate-scaffold terms.
GO:0046578 regulation of Ras protein signal transduction	NAS PMID:8618896 Phosphotyrosine-independent binding of a 62-kDa protein to t...	KEEP AS NON CORE	Summary: Author statement on regulation of Ras signal transduction (early RASA1/Lck-binding work). Reason: Historical/weak; non-core.
GO:0016236 macroautophagy	ISS GO_REF:0000024	ACCEPT	Summary: Direct/mutant-phenotype evidence that p62 functions in macroautophagy as a selective cargo receptor. Reason: Core biological process; strongly supported across multiple IDA/IMP studies.
GO:0006914 autophagy	TAS PMID:19816510 Essential role of the unfolded protein response regulator GR...	ACCEPT	Summary: Involvement in autophagy, the overarching process in which p62 functions as a selective receptor. Reason: Core process; supported by IMP/IDA evidence.
GO:0005080 protein kinase C binding	IPI PMID:14676191 Comprehensive proteomic analysis of human Par protein comple...	KEEP AS NON CORE	Summary: Protein kinase C binding via the PB1 domain (atypical PKCs PRKCZ/PRKCI). Reason: Genuine interaction underlying the NF-kB scaffold role; secondary to the core autophagy-receptor function.
GO:0006511 ubiquitin-dependent protein catabolic process	TAS PMID:8702753 p62, a phosphotyrosine-independent ligand of the SH2 domain ...	KEEP AS NON CORE	Summary: Author statement linking p62 to ubiquitin-dependent protein catabolism (early polyubiquitin-binding work). Reason: Correct but generic; the specific autophagic targeting/catabolic terms are more informative.
GO:0030971 receptor tyrosine kinase binding	TAS PMID:8650207 Molecular cloning of a phosphotyrosine-independent ligand of...	KEEP AS NON CORE	Summary: Author statement on receptor tyrosine kinase binding (TrkA/NTRK1). Reason: Genuine RTK interaction underlying NGF/NF-kB signaling; secondary, non-core.
GO:0043122 regulation of canonical NF-kappaB signal transduction	IMP PMID:12857745 Structure of the ubiquitin-associated domain of p62 (SQSTM1)...	ACCEPT	Summary: Mutant-phenotype evidence that p62 regulates canonical NF-kB signaling (UBA-domain-dependent ubiquitin binding). Reason: Well-established signaling-scaffold function; directly demonstrated (PMID:12857745).
GO:0043130 ubiquitin binding	IDA PMID:12857745 Structure of the ubiquitin-associated domain of p62 (SQSTM1)...	ACCEPT	Summary: Direct evidence that p62 binds ubiquitin via its UBA domain. Reason: Core molecular function underlying cargo recognition.
GO:0005829 cytosol	TAS PMID:8650207 Molecular cloning of a phosphotyrosine-independent ligand of...	ACCEPT	Summary: Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation. Reason: Core localization; many redundant TAS/IDA copies.
GO:0008104 intracellular protein localization	TAS PMID:8650207 Molecular cloning of a phosphotyrosine-independent ligand of...	KEEP AS NON CORE	Summary: Author statement on a role in intracellular protein localization (early aPKC/endosome targeting work). Reason: Broad/historical; non-core.
GO:0016197 endosomal transport	TAS PMID:12857745 Structure of the ubiquitin-associated domain of p62 (SQSTM1)...	KEEP AS NON CORE	Summary: Author statement on endosomal transport (NF-kB/TRAF6 signaling context). Reason: Secondary trafficking role; non-core.
GO:0019901 protein kinase binding	IDA PMID:8650207 Molecular cloning of a phosphotyrosine-independent ligand of...	KEEP AS NON CORE	Summary: Protein kinase binding (e.g. atypical PKCs, ULK1, MAP2K5) underlying p62 signaling scaffolds. Reason: Genuine but generic interaction class; secondary to the core function.
GO:0035556 intracellular signal transduction	TAS PMID:8650207 Molecular cloning of a phosphotyrosine-independent ligand of...	KEEP AS NON CORE	Summary: Author statement on involvement in intracellular signal transduction (Lck/NF-kB scaffolding). Reason: Broad signaling role; non-core.
GO:0042169 SH2 domain binding	IDA PMID:8650207 Molecular cloning of a phosphotyrosine-independent ligand of...	KEEP AS NON CORE	Summary: SH2 domain binding - the original phosphotyrosine-independent Lck SH2-domain ligand activity. Reason: Historical/defining-but-peripheral interaction; non-core.
GO:0045944 positive regulation of transcription by RNA polymerase II	TAS PMID:12857745 Structure of the ubiquitin-associated domain of p62 (SQSTM1)...	KEEP AS NON CORE	Summary: Reactome curation linking p62 to positive regulation of Pol II transcription (NRIF pathway). Reason: Indirect transcriptional effect; non-core.

Gene Description

Existing Annotations Review

Core Functions

Acts as the prototypical selective autophagy receptor, recognizing ubiquitinated cargo (preferentially K63-linked polyubiquitin) through its UBA domain and bridging it to ATG8-family proteins on the autophagosome via its LIR motif, thereby delivering cargo for autophagic degradation.

Acts as an activator of the NFE2L2/NRF2 antioxidant pathway by sequestering KEAP1 (via the phospho-Ser349 KIR motif) into p62 bodies, preventing KEAP1-mediated NRF2 degradation and inducing cytoprotective gene expression; SQSTM1 is itself an NRF2 target, forming a positive feedback loop.

Serves as a signaling adaptor/scaffold that assembles multiprotein complexes (e.g. atypical PKCs, TRAF6, RIPK1) to regulate NF-kB and related innate-immune signaling, including negative regulation of TLR4 signaling through control of the TRAF6-ECSIT complex.

References

Suggested Questions for Experts

Suggested Experiments

Deep Research

Falcon

📚 Additional Documentation

Notes

Pn Notes

📄 View Raw YAML