MetaboLights MTBLS19 → GO BP enrichment
Input: MetaboLights MTBLS19
Generated by go_bp_enrichment.py — GO
biological-process ORA via the enzyme/gene layer: metabolite → Rhea
reaction → human Swiss-Prot enzyme (UniProt) → GO BP, with is_a/part_of
closure and a one-sided hypergeometric test (BH-FDR). Live + cached.
- Foreground: 143 human enzymes catalysing reactions that involve the study
metabolites (20 metabolites mapped to reactions). - Background: 4052 human reviewed metabolic enzymes with ≥1 GO BP term.
- Currency/cofactor metabolites: excluded by Rhea reaction-degree ≥ 500 (0 of the study's metabolites dropped: none).
Top enriched GO biological processes
| GO BP term | k/n | K/N | Fold | FDR |
|---|---|---|---|---|
| GO:0006629 lipid metabolic process | 123/143 | 829/4052 | 4.2× | 3.3e-63 |
| GO:0016042 lipid catabolic process | 68/143 | 233/4052 | 8.3× | 3.2e-46 |
| GO:0006631 fatty acid metabolic process | 65/143 | 257/4052 | 7.2× | 1.6e-39 |
| GO:0032787 monocarboxylic acid metabolic process | 72/143 | 398/4052 | 5.1× | 3.9e-34 |
| GO:0001676 long-chain fatty acid metabolic process | 38/143 | 106/4052 | 10.2× | 1.7e-27 |
| GO:0046503 glycerolipid catabolic process | 27/143 | 51/4052 | 15.0× | 1.5e-24 |
| GO:0046470 phosphatidylcholine metabolic process | 28/143 | 57/4052 | 13.9× | 2.1e-24 |
| GO:0046475 glycerophospholipid catabolic process | 22/143 | 31/4052 | 20.1× | 6.7e-24 |
| GO:0015718 monocarboxylic acid transport | 33/143 | 97/4052 | 9.6× | 6.4e-23 |
| GO:0009395 phospholipid catabolic process | 24/143 | 42/4052 | 16.2× | 6.4e-23 |
| GO:0019752 carboxylic acid metabolic process | 73/143 | 607/4052 | 3.4× | 6.4e-23 |
| GO:0006644 phospholipid metabolic process | 47/143 | 241/4052 | 5.5× | 4.5e-22 |
| GO:0043436 oxoacid metabolic process | 73/143 | 627/4052 | 3.3× | 4.5e-22 |
| GO:0046486 glycerolipid metabolic process | 45/143 | 225/4052 | 5.7× | 1.7e-21 |
| GO:0015909 long-chain fatty acid transport | 21/143 | 33/4052 | 18.0× | 1.9e-21 |
| GO:0015908 fatty acid transport | 24/143 | 50/4052 | 13.6× | 1.1e-20 |
| GO:0006650 glycerophospholipid metabolic process | 40/143 | 185/4052 | 6.1× | 3.3e-20 |
| GO:0046471 phosphatidylglycerol metabolic process | 19/143 | 29/4052 | 18.6× | 1.0e-19 |
| GO:0009056 catabolic process | 75/143 | 776/4052 | 2.7× | 7.9e-18 |
| GO:0019369 arachidonate metabolic process | 22/143 | 58/4052 | 10.7× | 3.4e-16 |
| GO:0006869 lipid transport | 35/143 | 178/4052 | 5.6× | 4.4e-16 |
| GO:0010876 lipid localization | 35/143 | 178/4052 | 5.6× | 4.4e-16 |
| GO:0008610 lipid biosynthetic process | 53/143 | 430/4052 | 3.5× | 7.2e-16 |
| GO:0044281 small molecule metabolic process | 87/143 | 1117/4052 | 2.2× | 1.6e-15 |
| GO:0072330 monocarboxylic acid biosynthetic process | 31/143 | 146/4052 | 6.0× | 4.1e-15 |
| GO:0006670 sphingosine metabolic process | 13/143 | 18/4052 | 20.5× | 3.5e-14 |
| GO:0046519 sphingoid metabolic process | 13/143 | 19/4052 | 19.4× | 1.0e-13 |
| GO:0006690 icosanoid metabolic process | 24/143 | 93/4052 | 7.3× | 1.6e-13 |
| GO:0030149 sphingolipid catabolic process | 16/143 | 34/4052 | 13.3× | 1.8e-13 |
| GO:0033559 unsaturated fatty acid metabolic process | 24/143 | 94/4052 | 7.2× | 2.0e-13 |
Where this sits
This completes the bridge from metabolomics to GO biological process by
routing through the curated enzyme/gene annotations (the layer GO-CAM also
builds on). It is organism-specific (human) by construction.
Compare with GO molecular-function enrichment (activities) on the same metabolites.