PN row 1: Ubiquitin Proteasome System | E3 ubiquitin and UBL ligases | Cullin | degenerate, possible CUL3 inhibitor
UniProt: Q86Y37
In branches: UPS
Signature domains: IPR001373
Auxiliary domains: (none)
PN references (titles):
26238671
PN-node mapping records (path + ancestors):
[type] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, possible CUL3 inhibitor
status=no_mapping scope= GO=[]
rationale: Reviewed as a contextual, regulatory, adaptor, or uncertain UPS bucket. The shared label does not by itself establish a safe gene-level GO propagation.
[group] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin
status=mapped scope=ok_for_propagation_to_go GO=[GO:0160072 ubiquitin ligase complex scaffold activity]
rationale: This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity.
[class] Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases
status=context_only scope=too_broad_to_propagate GO=[GO:0061630 ubiquitin protein ligase activity]
rationale: This class is a genuine E3-ligase context, but its descendants include catalytic ligases, cullin scaffolds, substrate receptors, adaptors, cofactors, regulators, and UBL modifier systems. A class-level propagation would over-annotate.
[branch] Ubiquitin Proteasome System
status=no_mapping scope= GO=[]
rationale: Reviewed as the top-level UPS branch. It is a project taxonomy umbrella rather than a direct GO assertion; UPS propagation must come from manually curated child nodes.