PN placement:Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin ; PN-node mapping: group Cul3 substrate receptor=mapped→GO:1990756 ubiquitin-like ligase-substrate adaptor activity (new_to_goa); class E3 ubiquitin and UBL ligases=context_only (too_broad→GO:0061630); subtype/type/branch=no_mapping.
Consistency: Deep-research (manual fallback), notes, review YAML, and the PN Cul3-adaptor mapping are mutually consistent. All converge on ABTB2 as a BTB/POZ substrate-adaptor that binds CUL3 and promotes TRAP1 ubiquitin-dependent degradation (PMID:41322190). No contradictions. The review prudently treats older BPOZ-2 papers as nomenclature-ambiguous with ABTB1 and excludes them as primary evidence.
PN story / NEW pressure: PN asserts adaptor activity not in the original GOA (which had only GO:0046982 heterodimerization IEA, GO:0005515 protein binding IPI, GO:0005654 nucleoplasm). The review adds the PN-projected GO:1990756 (OLS-verified real) as a direct IDA NEW annotation, supported by ABTB2-TRAP1 co-IP, TRAP1 ubiquitination/degradation, and reported ABTB2-cullin-3 interaction, plus companion GO:0016567 protein ubiquitination. This is gene-specific support, not domain-only projection. Conclusion: legitimate ADD, executed in the review.
Mapping strategy: This gene strengthens the Cul3-substrate-receptor group mapping with direct experimental evidence (unlike its paralog ABTB3). The group-level GO:1990756 scope is appropriate (adaptor activity, not catalytic E3); the review correctly avoids GO:0061630 ubiquitin protein ligase activity. No change needed.
Evidence alignment: PN row references (PMID:15071497, 23912815 — generic Cul3/BTB reviews) do NOT overlap the review's primary evidence (PMID:41322190, the 2025 PDAC study); the review rests on stronger gene-specific data than the PN row's domain-review citations. Generic 14-3-3 interactome (PMID:36931259) shared but marked over-annotated.
Verdict: Fully consistent; PN GO:1990756 projection validated by direct evidence and correctly added as NEW. Recommended edits: none (mapping and review aligned).