Consistency: Deep research/notes, review, and PN diverge in emphasis. ATP6V0A4 is the a4 V0 a-subunit whose best-supported human biology is renal apical-plasma-membrane urinary acidification and inner-ear function (dRTA, hearing loss; PMID:10973252, PMID:14638902, PMID:12414817), NOT primarily lysosomal. The review does NOT add GO:0046610 or GO:0007042; it keeps lysosomal membrane KEEP_AS_NON_CORE (HDA, PMID:17897319) and explicitly questions the PN lysosomal projection.
PN story / NEW pressure: PN projects the same lysosomal V0/acidification terms it gives the c''/d2 subunits, but a4 lacks direct isoform-specific lysosomal-acidification evidence. The review's restraint is correct: the lysosomal projection over-reaches for a4 (the a-subunit isoforms are differentially targeted; a4 → apical PM, not lysosome). proposed_new_terms empty; lysosomal terms NOT added. Over-reaches / correctly declined in review.
Mapping strategy: This gene should change the node treatment: ATP6V0A4 is a weak/contraindicated member of the "lysosomal V0 component" leaf. GO:0046610/GO:0007042 are narrower than what a4 evidence supports and risk a false lysosome-specific claim — the TOMM20/RAB7A "leaf doesn't fit this member" pattern. The leaf mapping is fine for c''/d2 but should be flagged not-for-propagation to a4.
Evidence alignment: PN cites generic V-ATPase/mTORC1 titles (none a4-specific); review cites a rich a4-specific renal/inner-ear literature (PMID:10973252, 12649290, 14638902, 17360703, 12414817) entirely absent from the PN row. Clear divergence; review is far better sourced.
Verdict: PN LYSOSOMAL PROJECTION OVER-REACHES for a4 (renal-apical, not lysosomal); review correctly declined. Recommended edits: [MAP] flag GO:0046610 + GO:0007042 leaf/type projections as not_for_propagation to ATP6V0A4 (no a4-specific lysosomal evidence; isoform is apical-PM targeted); keep GO:0033179 (V0 domain, already in GOA).