Consistency: CONFLICT on compartment. Review/notes establish G2 as the brain/neuron-enriched G-subunit isoform whose core process is synaptic vesicle lumen acidification (GO:0097401, ACCEPT IBA+IEA) at the synaptic vesicle membrane (GO:0030672, GO:0098850, ACCEPT); also non-core melanosome (EXP PMID:17081065). The review asserts NO lysosomal role and MARKs_AS_OVER_ANNOTATED the macroautophagy NAS. PN places G2 under "lysosomal v-ATPase" and projects lysosomal lumen acidification — mismatched to the established synaptic-vesicle biology. PN Notes template ("pumps protons into the lysosome") mis-frames this neuronal isoform.
PN story / NEW pressure: PN's lysosomal lumen acidification (new_to_goa) OVER-REACHES for G2; the evidenced acidification target is the synaptic vesicle lumen, already captured by GO:0097401 (more specific and correct). GO:0046612/GO:0007042 verified real but wrong specialization. Lysosomal projection should NOT be propagated; the review already has the correct compartment-specific acidification term.
Mapping strategy: Tissue-restricted neuronal isoform; lysosomal projection is over-broad (TOMM20/HSPA8/RAB7A precedent). [MAP] flag G2 as an exception — its acidification specialization is synaptic-vesicle (GO:0097401), not lysosomal; safe complex target is GO:0000221/GO:0016471 (already in review).
Evidence alignment: No overlap. PN cites generic V-ATPase/mTORC1 reviews; review cites G2-specific PMID:10202016 (MHC locus/identity, in notes), PMID:12384298 (brain tissue-specificity), PMID:17081065 (melanosome EXP), plus over-annotated interactome PMIDs. Review better-targeted.
Verdict: OVER-REACH — PN lysosomal projection wrong-compartment for this brain/synaptic-vesicle isoform; correct acidification term (GO:0097401) already present. Recommended edits: [MAP] exempt ATP6V1G2 from lysosomal-acidification/lysosomal-V1 projection; route to synaptic-vesicle acidification + vacuolar V1 complex terms already in the review.