Consistency: CONFLICT on compartment. Review/notes establish G3 as the kidney-enriched (plus inner-ear) G isoform that assembles the tissue-specific pump (a4/B1/C2/d2) at the apical plasma membrane of collecting-duct intercalated cells for luminal acid secretion (IDA plasma membrane PMID:17360703; ATPase binding to a4/a1, IPI). The review explicitly KEEPs_AS_NON_CORE the IBA synaptic-vesicle/synaptic-vesicle-acidification annotations as generic family transfers irrelevant to G3, and asserts NO lysosomal role. PN places G3 under "lysosomal v-ATPase" and projects lysosomal lumen acidification — contradicting the plasma-membrane renal biology. PN Notes template ("pumps protons into the lysosome") mis-frames this isoform.
PN story / NEW pressure: PN's lysosomal lumen acidification (new_to_goa) OVER-REACHES for G3; evidenced compartment is apical plasma membrane (GO:0005886, IDA, ACCEPT), function is renal luminal acid secretion. GO:0046612/GO:0007042 verified real but wrong specialization. Lysosomal projection should NOT be propagated.
Mapping strategy: Tissue-restricted plasma-membrane isoform; lysosomal projection over-broad (TOMM20/HSPA8/RAB7A precedent). [MAP] flag G3 as an exception — safe targets are vacuolar V1 domain/complex (GO:0000221/GO:0016471) + plasma-membrane acid-secretion context already in the review; the specific G3-a-subunit ATPase-binding (GO:0051117) is the mechanistically informative core, not lysosomal acidification.