PN placement:ALP → Autophagosome closure maturation and lysosome fusion → Sealing of autophagophore membrane → ESCRT-III complex component AND ALP → Microautophagy → General microautophagy machinery → ESCRT-III complex component (2 rows; shared CHMP template)
PN-node mapping: type → GO:0000815 ESCRT III complex (already_in_goa_exact); "Sealing" group → GO:0000045 autophagosome assembly (more_specific_than_existing_goa); classes context_only/too_broad; branch no_mapping.
Consistency: Consistent. The review identifies CHMP6 as the human Vps20 ortholog — the myristoylated ESCRT-II→ESCRT-III nucleator/acceptor (bridges ESCRT-II to CHMP4 polymerization), which is mechanistically upstream of sealing rather than the sealing effector itself. PN's generic component placement and the review's nucleator framing agree; autophagy entries (GO:0097352 IEA, GO:0016236 TAS PMID:20588296) are KEEP_AS_NON_CORE. No contradiction.
PN story / NEW pressure: PN projects GO:0000045 autophagosome assembly (verified real). CHMP6 support is family/role-inheritance, not a CHMP6-specific closure assay; the review explicitly states "cached evidence does not make CHMP6-specific autophagosome maturation the core function" and raises a suggested_question on this. A gene-specific GO:0000045 would over-reach. PN over-reaches for CHMP6 — already captured at non-core altitude; do not ADD.
Mapping strategy: No change. CHMP6's nucleation role fits the ESCRT-III-complex leaf (GO:0000815) well, but its upstream position makes the "Sealing" group→GO:0000045 projection a poor gene-specific fit; class-level context_only is the right ceiling.
Evidence alignment: Divergent. PN cites only the Cells "Key Regulators of Autophagosome Closure" review. Review cites primary literature (PMID:15511219 CHMP6/ESCRT-II acceptor, PMID:17984323, PMID:20588296, PMID:36107470 [verified]). No shared specific citations.
Verdict: Consistent; review correctly distinguishes CHMP6's nucleator role from generic sealing and resists the autophagy projection. Recommended edits: none.