CLGN

UniProt: O14967 · batch: proteostasis-batch-2026-06-07 · review status: COMPLETE
PN placement: ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone ; PN-node mapping: leaf [type] Lectin chaperone no_mapping; [group] N-glycosylation system → mapped GO:0006487 protein N-linked glycosylation (new_to_goa); class/branch unmapped.
Consistency: Mostly consistent on identity (testis-specific calnexin-family lectin-type ER membrane chaperone; clients = ADAM1/2/ADAM3; essential for sperm-zona binding/fertility) across notes, YAML, and PN. The friction is the projected GO term: the PN node projects GO:0006487 (the biosynthetic process that adds N-glycans), but CLGN is a lectin chaperone that binds monoglucosylated N-glycans on clients — it does not catalyze glycan transfer. The review correctly annotates GO:0044183 protein folding chaperone / GO:0006457 protein folding, not glycosylation.
PN story / NEW pressure: PN's "N-glycosylation system" framing over-reaches when projected as GO:0006487 for a lectin chaperone. CLGN's real, review-captured roles (folding chaperone, single fertilization GO:0007338) are already in GOA/review. GO:0006487 is verified real but is the WRONG process for this gene's mechanism → over-reaches; do not ADD to the gene.
Mapping strategy: The [group] projection is the problem. GO:0006487 is broader/orthogonal to what lectin chaperones do; it is analogous to the TOMM20/HSPA8/RAB7A "broader, rejected" precedent — the node groups the N-glycosylation machinery but its members (OST subunits vs lectin chaperones) do not share GO:0006487. Recommend the group either map to a glycoprotein-QC/folding term (e.g. a chaperone-mediated folding concept) or leave lectin-chaperone members unmapped at this node, so GO:0006487 is not propagated to CLGN.
Evidence alignment: PN listed no reference titles for this row. Review anchors on PMID:9177349 (knockout/zona-adhesion), PMID:17507649 (PDILT complex), PMID:9434179 (cloning). No conflict; the divergence is term choice, not evidence.
Verdict: Identity consistent, but PN GO:0006487 projection over-reaches for a lectin chaperone (binds, not synthesizes, N-glycans); should not propagate to CLGN.

Recommended edits: [MAP] Do not propagate GO:0006487 from N-glycosylation system to lectin-chaperone members (CLGN); remap the group to a folding/glycoprotein-QC term or leave lectin chaperones unmapped. [YAML] No glycosylation annotation should be added to CLGN.