ERLIN2

UniProt: O94905 (ERLN2_HUMAN, SPFH2; 3 isoforms) · batch: proteostasis-batch-2026-06-11 · review status: COMPLETE (all actioned; 11 plasma-membrane Reactome annotations MARK_AS_OVER_ANNOTATED).
PN placement: ER proteostasis|Organelle-specific protein degradation|ER associated degradation|ER handling of ERAD substrates and Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|noncatalytic / BAND 7 ; PN-node mapping: [group ERAD] mapped/exact GO:0036503; [type ER-handling] mapped/ok_for_propagation GO:0036503; [group idiosyncratic RING complex] mapped/ok_for_propagation GO:0000151 ubiquitin ligase complex; subtype/type/branch no_mapping; UPS class context_only/too_broad GO:0061630. (Dossier identical to ERLIN1.)
Consistency: Strong. Deep research (Veronese 2024 scaffold/TMUB1-RNF170; Zhu 2023 iPSC Ca2+/IP3R1; Cioffi/Trinchillo 2024 SPG18) ↔ review YAML (ERAD of IP3R + HMGCR via gp78/AMFR, cholesterol binding, SREBP restriction, E3-ligase binding RNF170/AMFR/SYVN1/RNF139/RNF185-RNF5, membrane raft) ↔ PN annotation all agree. No contradictions.
PN story / NEW pressure: PN asserts ERAD + non-catalytic E3-complex membership — both already captured (GO:0036503 IDA PMID:19240031; GO:0031625 ubiquitin protein ligase binding has an experimental IPI PMID:24019521, stronger than ERLIN1). Sterol-accelerated HMGCR ERAD (PMID:21343306) and the 2024 scaffold/cholesterol-esterification role (PMID:38782601) extend beyond GOA but are cited. No NEW term forced; optional MF ADD GO:0160072 "ubiquitin ligase complex scaffold activity" (verified real). Verdict: already captured; scaffold-activity term optional.
Mapping strategy: Same as ERLIN1 — ERAD mapping correct; GO:0000151 over-reaches (catalytic-complex CC projected onto non-catalytic BAND 7 scaffold). Prefer GO:0000835 "ER ubiquitin ligase complex" (verified real). Distinct from ERLIN1: the plasma-membrane annotations are correctly MARK_AS_OVER_ANNOTATED (Reactome FGFR1 bulk-membrane curation), consistent with ER-membrane SPFH biology — handled well, no change needed.
Evidence alignment: PN cites opaque workbook IDs (1610068, 41481136 — not PMIDs). Review anchors to PMID:19240031, 24217618, 21343306, 24019521, 38782601, 40225166 + ComplexPortal CPX-7121. Note review flags RNF213 (Zhu/PMID:40225166) as a mutant-context ligase distinct from canonical RNF170 — correctly not conflated.
Verdict: Consistent and high-quality; PN story already captured. GO:0000151 projection mildly over-reaches (non-catalytic scaffold); prefer GO:0000835 / GO:0160072. PM over-annotation correctly handled.

Recommended edits: [MAP] Replace/qualify the GO:0000151 group projection with GO:0000835 "ER ubiquitin ligase complex" (CC), noting ERLINs are non-catalytic BAND 7 subunits. [YAML, optional] Consider adding MF GO:0160072 "ubiquitin ligase complex scaffold activity" to core_functions.