PN placement:UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|CASH (aux domain IPR006633) ; PN-node mapping: subtype/type no_mapping; group Cul1 substrate receptor=mapped / ok_for_propagation_to_go → GO:1990756 (new_to_goa); class context_only/too_broad (GO:0061630).
Consistency: Consistent and well-aligned. Review explicitly executes the canonical F-box pattern: two NAS GO:0004842 ubiquitin-protein transferase annotations MODIFY → GO:1990756 (verified real), exactly matching the PN projection. DR ↔ YAML agree on BCL2/HGAL/PGAM5/RAGE substrates and SCF(FBXO10) membership.
PN story / NEW pressure: PN asserts the adaptor MF; review supplies it via MODIFY of the wrong catalytic-transferase terms — already captured/improved, not over-reach. Beyond the PN family story, the review carries substantial extra biology (apoptosis via BCL2 IMP PMID:23431138; mitochondrial OMM PGAM5 degradation; species caveat from Fbxo10 KO mice) that PN does not assert. No additional NEW GO pressure beyond GO:1990756. Validated substrates present (not a substrate-less F-box).
Mapping strategy: Gene does not change the node; status/scope correct. PN-projected GO:1990756 is at correct altitude (matches the review's MODIFY replacement target). Class GO:0061630 correctly too_broad.
Evidence alignment: PN cites only 15340381. Review uses PMID:23431138 (BCL2), 31570756 (HGAL), 34445249 (SCF), 10531035/10531037 (family cloning, source of the transferase NAS terms), plus Falcon PGAM5/RAGE leads. Expansion, no conflict.
Verdict: Consistent; review already implements the PN adaptor-MF mapping via MODIFY GO:0004842→GO:1990756.
Recommended edits: none to FBXO10-ai-review.yaml. [MAP] none — node mapping and review concur.