PN placement:UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other ; PN-node mapping: subtype/type no_mapping; group Cul1 substrate receptor=mapped / ok_for_propagation_to_go → GO:1990756 (new_to_goa); class context_only/too_broad (GO:0061630).
Consistency: Consistent. DR ↔ YAML agree FBXO16 is a nuclear-acting CRL1/SCF substrate receptor driving K48-linked degradation of beta-catenin, hnRNPL, ULK1, RELA/p65. Review ACCEPTs SCF complex (GO:0019005) and SCF-dependent catabolism (GO:0031146); GO:1990756 is the core MF, matching PN.
PN story / NEW pressure: PN asserts the adaptor MF. GO:1990756 (verified real) is NOT in GOA for FBXO16 — but, as with FBXO8, it appears only in core_functions, not as a NEW existing_annotation; FBXO16 has NO MF annotation in its existing_annotations at all (only protein binding IPI + two NAS CC/BP). So the adaptor MF is a defensible ADD that the review states but does not formally annotate. Validated substrates present (not substrate-less).
Mapping strategy: Gene does not change the node; status/scope correct. PN-projected GO:1990756 at right altitude. Class GO:0061630 too_broad. A nuclear-localization theme (DR) is not yet annotated but PN does not assert it either.
Evidence alignment: PN cites only 15340381. Review uses PMID:32296183 (binary interactome, LOW), 34445249 (SCF/ComplexPortal CPX-7926), plus Falcon substrate leads (Khan 2019, Ji 2021, Zhang 2024, Sugimoto-Ishige 2025). Expansion, no conflict.
Recommended edits: [YAML] consider adding GO:1990756 as a NEW MF existing_annotation (currently FBXO16 carries no MF annotation; the adaptor activity lives only in core_functions) — mirrors the explicit NEW done for FBXO15. [MAP] none.