FKBP8

UniProt: Q14318 · batch: proteostasis-batch-2026-06-07b · review status: COMPLETE
PN placement: 3 rows — (1) Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing; (2) Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type; (3) Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy. PN-node mapping: HSP90-cochaperone type=mapped→GO:0051879 Hsp90 protein binding (more_specific_than_existing_goa); PPIase group/type=mapped→GO:0003755 PPIase activity (already_in_goa_exact); Mitophagy type=mapped→GO:0000423 mitophagy (supported_by_goa_regulation); subtype/class/group/branch=no_mapping.
Consistency: Notes, review YAML, and all three PN mappings are mutually consistent. The review captures the full dual-role membrane-FKBP picture: conditional Ca2+/CaM-activated PPIase (GO:0003755, ACCEPT), HSP90 co-chaperone (multiple protein-binding rows MODIFY→GO:0051879), and mitophagy receptor (GO:1901524 ACCEPT x2). No contradiction.
PN story / NEW pressure: All three PN molecular roles are already in GOA/review. GO:0051879 (OLS-verified) is correctly "more_specific" — the review independently proposes it via MODIFY of HSP90 protein-binding rows. GO:0003755 is already_in_goa_exact (review ACCEPT, IEA). Mitophagy: PN maps GO:0000423 (mitophagy, verified real) but the review and GOA carry GO:1901524 regulation of mitophagy (IDA x2, PMID:28381481/31908024), not GO:0000423 itself — PN flags this honestly as supported_by_goa_regulation (FKBP8 is a receptor that regulates, rather than is, mitophagy). Nothing to ADD; all captured.
Mapping strategy: Three leaf mappings, all defensible and gene-appropriate; ancestors correctly no_mapping (TOMM20/HSPA8-style umbrella restraint). One nuance: the Mitophagy-receptor leaf projects GO:0000423 (the process), whereas FKBP8's experimental evidence is for the regulation term GO:1901524. supported_by_goa_regulation captures this, but if the projection is meant to land an annotation, GO:1901524 is the better-supported target.
Evidence alignment: PN row-3 titles ("FKBP8 recruits LC3A to mediate Parkin-independent mitophagy" = PMID:28381481; "Selective Autophagy: ATG8…LIR…Cargo Receptors") overlap the review's mitophagy anchors (PMID:28381481 cited; PMID:31908024 added). Strong overlap on mitophagy; PN does not surface the HSP90/dynein-relay (PMID:29916806) or CaM-activation (PMID:20707607) evidence the review adds — enrichment, not conflict.
Verdict: Consistent; all PN molecular roles captured; only nuance is mitophagy process (GO:0000423) vs regulation (GO:1901524) granularity. Recommended edits: [MAP] optionally retarget the Mitophagy-receptor leaf projection from GO:0000423 to GO:1901524 regulation of mitophagy to match FKBP8's experimental (IDA) evidence and the review.