SGTA

UniProt: O43765 · batch: proteostasis-batch-2026-06-07b · review status: COMPLETE
PN placement: Cytonuclear|Chaperone|HSP70-HSP90 joint cochaperone|CC-TPR and SGTA dimerization domain; ER proteostasis|Protein transport|GET pathway component ; PN-node mapping: mapped → GO:0031072 (HSP binding, more_specific_than_existing_goa), GO:0015031 (protein transport, new), GO:0006620 (post-translational ER targeting, already_in_goa_exact)
Consistency: Good. Review, notes and PN agree: cytosolic TPR co-chaperone for tail-anchored/hydrophobic clients, acting with BAG6 and ASNA1/TRC40 (GET) to deliver TA proteins to the ER; QC rheostat antagonizing RNF126/BAG6. Core MFs = molecular adaptor activity (GO:0060090), BAT3-complex binding (GO:1904288); core BP = GO:0006620 + GO:0071816 (TA insertion). GET role consistent with PN.
PN story / NEW pressure: No genuinely new role. PN's GO:0006620 already in review (ACCEPT, core) and GOA-exact. PN's GO:0015031 protein transport is a parent of the review's more specific GO:0006620/GO:0071816 → already captured at finer grain. PN's GO:0031072 (HSP binding) is broader than the review's GO:0051879 (Hsp90 binding). Conclude: already captured / over-reaches — nothing to ADD.
Mapping strategy: Both PN projections that aren't already exact (GO:0015031, GO:0031072) are BROADER than the review's terms (TOMM20/HSPA8/RAB7A precedent: reject broader). PN already self-flags them new/more_specific but they should not displace the gene-level specific terms. No mapping change warranted.
Evidence alignment: Review cites GET/BAG6 literature (e.g. PMID:23129660) and UniProt; PN row carries no extra reference titles, so no divergence to reconcile.
Verdict: Consistent; PN adds breadth only, no new defensible term. Recommended edits: none required; treat GO:0015031 and GO:0031072 as broader-than-review and do not propagate (gene-level GO:0006620/GO:0071816/GO:0051879 already finer) [MAP].