UFSP1

UniProt: Q6NVU6 · batch: proteostasis-batch-2026-06-07c · review status: COMPLETE
PN placement: two rows — Translation|Cytosolic translation|Ribosome-associated QC|UFMylation and Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase ; PN-node mapping: type/group both mapped, ok_for_propagation → GO:0071569 protein ufmylation, GO:0071567 deUFMylase activity, plus group-level GO:0006515 PQC for misfolded/incompletely synthesized proteins (from RQC group); UPS class/branch no_mapping.
Consistency: Strong. Deep-research notes, review YAML, PN annotation and PN-node mapping all converge: UFSP1 is an active UFM1-specific cysteine protease (deUFMylase) that matures pro-UFM1 and removes an autoinhibitory UFM1 mark on UFC1; it is cytosolic and (unlike UFSP2) does NOT deUFMylate RPL26. GOA cross-check confirms goa_status: GO:0071567 already-in-GOA (4 records), GO:0071569 already-in-GOA (2), GO:0006515 new-to-GOA (0). No contradictions.
PN story / NEW pressure: PN's deUFMylase + ufmylation story is fully captured by existing annotations (GO:0071567 IDA/IBA, GO:0071569 IDA, GO:0008234, GO:0051604). The one element NOT in GOA is the group-level GO:0006515 (PQC). For UFSP1 this over-reaches: UFSP1 acts on UFM1/UFC1 maturation in the cytosol, not on ribosome-associated QC of misfolded/stalled nascent chains (that arm is UFSP2/RPL26). No defensible NEW term needed; deUFMylase activity already captured.
Mapping strategy: UFSP1 does not change the UPS-side node (correctly anchored on GO:0071567). On the Translation/RQC side, the GROUP→GO:0006515 projection is too broad for UFSP1 specifically (cytosolic UFM1-maturation enzyme, not a misfolded/incomplete-protein degradation factor). Status/scope on the deUFMylase nodes are right.
Evidence alignment: PN row 2 cites PMID:29476094 (Millrine UFSP review) — not in the review YAML, which instead anchors on the two primary 2022 papers (PMID:35525273, PMID:35926457) plus the HuRI interactome (PMID:32296183). Same biology, complementary references; no conflict.
Verdict: Consistent and complete; the only flag is the RQC-group GO:0006515 projection over-reaching for cytosolic UFSP1.

Recommended edits: [MAP] do not project group-level GO:0006515 (PQC for misfolded/incompletely synthesized proteins) onto UFSP1 — UFSP1 is a cytosolic UFM1-maturation/deUFMylase enzyme, not a ribosome-associated misfolded-protein QC factor (contrast UFSP2/RPL26).