UPF1

UniProt: Q92900 · batch: proteostasis-batch-2026-06-07c · review status: COMPLETE
PN placement: Translation|Cytosolic translation|Translation termination|Modulation of termination ; PN-node mapping: type (Modulation of termination) no_mapping; group (Translation termination) mapped, ok_for_propagation → GO:0006415 translational termination; class/branch context_only, too_broad. Projected: GO:0006415 (goa_status=supported_by_goa_regulation).
Consistency: Mostly consistent on the gene's biology — deep-research/notes, review YAML and GOA all agree UPF1 is the central ATP-dependent SF1 RNA helicase/ATPase of NMD (core MF GO:0003724; core BP GO:0000184). But there is a framing tension with the PN-node mapping (see below): the review never frames UPF1 as a translation-termination factor; it is recruited at termination but its function is mRNA surveillance/decay, not polypeptide release.
PN story / NEW pressure: The PN "modulation of termination" story IS reflected in GOA — UPF1 carries GO:0006449 regulation of translational termination (verified real; 2 records, ECO:0000315/0000303), which the dossier correctly cites as supported_by_goa_regulation. This is the defensible frame and is already captured. No NEW term needed; UPF1's core (RNA helicase, NMD, ATPase) is fully annotated.
Mapping strategy: The GROUP projection onto GO:0006415 translational termination (verified: "release of a polypeptide chain from the ribosome … in response to a termination codon") is the wrong/over-broad term for UPF1 — UPF1 does not catalyze peptide release. UPF1 already has the precise GO:0006449 (regulation of termination) and GO:0000184 (NMD). The type-level no_mapping for "Modulation of termination" is correct; the group-level GO:0006415 projection should be GO:0006449, not GO:0006415, for UPF1 (precedent: TOMM20/HSPA8/RAB7A broader-term rejections).
Evidence alignment: PN row carries no reference titles; the review is heavily evidenced (NMD: PMID:26255671 TAS, GO:0000184 IEA; helicase: PMID:21419344, 26138914, 30218034 IDA; complex GO:0170010). No divergence to reconcile — PN provides no competing citations.
Verdict: Gene biology consistent; PN group→GO:0006415 (translational termination) over-reaches — UPF1's termination link is regulatory (GO:0006449), already in GOA.

Recommended edits: [MAP] for UPF1, replace/avoid the group projection GO:0006415 (translational termination, = peptide release) with GO:0006449 (regulation of translational termination), which is already in UPF1 GOA and is the accurate frame; UPF1's core remains NMD (GO:0000184) + RNA helicase (GO:0003724).