PN placement:UPS|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR ; PN-node mapping: group Cul1 substrate receptor=mapped/ok_for_propagation→GO:1990756; F-box/LRR subtype+type=no_mapping; class=context_only/too_broad→GO:0061630.
Consistency: Fully consistent. Falcon DR (VPS34/PIK3C3 phosphodegron axis; CAAX-isoprenylation/RIM1; PR55alpha), the review YAML, the PN F-box LRR substrate-receptor placement, and the GO:1990756 group mapping all converge. No contradictions.
PN story / NEW pressure: PN projects GO:1990756 (verified real, OLS: "binding...brings together a ubiquitin-like ligase and its substrate. Usually mediated by F-box...proteins") as new_to_goa. Review independently ADDS GO:1990756 as action: NEW (IDA, PMID:34731788), replacing five bare protein binding (SKP1/PR55alpha) IPI annotations. Matches PN projection exactly. Conclude: ADD — warranted and concordant.
Mapping strategy: Gene supports, does not change, the node. KEY PATTERN holds: F-box = SCF substrate receptor, catalysis in RBX1; the correct shared MF is the GO:1990756 adaptor term at the receptor group, with the catalytic GO:0061630 correctly held at class level as too_broad. No PN-projected term is broader than the review (unlike TOMM20/HSPA8 precedent). Scopes correct.
Evidence alignment: PN reference is only "15340381 / rev" (Jin et al. F-box family review), not directly in the review's PMID set; review anchors on the human PR55alpha study PMID:34731788 (HIGH/VERIFIED) plus FBXL family review PMID:33234069 and Falcon DR for the VPS34 axis. Divergence is benign — PN uses a generic family review; review uses gene-specific primary literature.
Verdict: Consistent; GO:1990756 NEW warranted and matches PN (new_to_goa). No over-reach.
Recommended edits: none to FBXL20-ai-review.yaml; PN mappings sound as-is.