ADRM1

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0008541 proteasome regulatory particle, lid subcomplex	IBA GO_REF:0000033	MODIFY	Summary: The evidence supports ADRM1/Rpn13 as a 19S regulatory-particle ubiquitin receptor, but the lid-subcomplex placement is less accurate for ADRM1 than the base-subcomplex placement used by the PN projection. Reason: Modify to proteasome regulatory particle, base subcomplex. Primary and structural literature describe Rpn13/ADRM1 as a 19S regulatory-particle subunit and as one of the base ubiquitin receptors; this supports the PN base-subcomplex projection and argues against retaining the lid-subcomplex term for ADRM1. Proposed replacements: proteasome regulatory particle, base subcomplex proteasome regulatory particle Supporting Evidence: PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex PMID:29636472 Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors Rpn10 and Rpn13, the base subunits within the holoenzyme PMID:33729481 Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin tag on the substrate file:human/ADRM1/ADRM1-deep-research-manual.md The Proteostasis PN projection is conservative for ADRM1; proteasome complex and regulatory-particle terms are safe, and literature supports modifying the lid-subcomplex annotation to the base subcomplex.
GO:0061133 endopeptidase activator activity	IBA GO_REF:0000033	MODIFY	Summary: ADRM1 activates the proteasome-associated deubiquitinase UCHL5/UCH37, so the current endopeptidase activator term is too generic and mechanistically imprecise. Reason: Modify to deubiquitinase activator activity. The cited evidence is about recruiting/activating UCH37/UCHL5 deubiquitinating activity at 26S proteasomes, not a broad endopeptidase activator role. Proposed replacements: deubiquitinase activator activity Supporting Evidence: PMID:16990800 hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes PMID:16990800 loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0070628 proteasome binding	IBA GO_REF:0000033	ACCEPT	Summary: ADRM1 binds/incorporates into the 26S proteasome regulatory particle through its Rpn13/Rpn2-associated receptor role. Reason: Accept as a direct molecular function. ADRM1 is a proteasome-associated ubiquitin receptor and interacts with the proteasome scaffolding protein Rpn2/PSMD1; this is also consistent with the PN regulatory-particle projection. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex PMID:20471946 hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding
GO:0005634 nucleus	IEA GO_REF:0000120	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005737 cytoplasm	IEA GO_REF:0000120	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005515 protein binding	IPI PMID:16713569 A protein-protein interaction network for human inherited at...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:16990800 A novel proteasome interacting protein recruits the deubiqui...	MODIFY	Summary: This protein-binding evidence is real but should be represented by more specific proteasome binding and UCHL5/UCH37 binding terms. Reason: Modify away from generic protein binding. The original evidence supports ADRM1 association with proteasome subunits and the UCHL5/UCH37 deubiquitinase, which are better captured by proteasome binding and ubiquitin-specific protease binding/deubiquitinase-regulator annotations. Proposed replacements: proteasome binding ubiquitin-specific protease binding Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:16990800 hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:17139257 hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds ...	MODIFY	Summary: This protein-binding evidence is real but should be represented by more specific proteasome binding and UCHL5/UCH37 binding terms. Reason: Modify away from generic protein binding. The original evidence supports ADRM1 association with proteasome subunits and the UCHL5/UCH37 deubiquitinase, which are better captured by proteasome binding and ubiquitin-specific protease binding/deubiquitinase-regulator annotations. Proposed replacements: proteasome binding ubiquitin-specific protease binding Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:16990800 hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:18497817 Proteasome subunit Rpn13 is a novel ubiquitin receptor.	MODIFY	Summary: This protein-binding row captures direct ubiquitin/UBL-substrate receptor evidence and should be replaced by ubiquitin binding. Reason: Modify to ubiquitin binding. Husnjak et al. identify Rpn13/ADRM1 as a proteasomal ubiquitin receptor and map ubiquitin binding to the Pru domain; generic protein binding hides the informative molecular function. Proposed replacements: ubiquitin binding Supporting Evidence: PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:20471946 Rpn13 functions as a ubiquitin receptor for the proteasome
GO:0005515 protein binding	IPI PMID:18922472 Distinct modes of regulation of the Uch37 deubiquitinating e...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:19490896 Assembly pathway of the Mammalian proteasome base subcomplex...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:19615732 Defining the human deubiquitinating enzyme interaction lands...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:20059542 Cross-species divergence of the major recognition pathways o...	MODIFY	Summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit interactions, but those should be represented with more specific terms. Reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is too broad for curation. Proposed replacements: ubiquitin binding proteasome binding Supporting Evidence: PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:20471946 hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding PMID:24811749 Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade ubiquitin-conjugated proteins
GO:0005515 protein binding	IPI PMID:21516116 Next-generation sequencing to generate interactome datasets.	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:24811749 Autoubiquitination of the 26S proteasome on Rpn13 regulates ...	MODIFY	Summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit interactions, but those should be represented with more specific terms. Reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is too broad for curation. Proposed replacements: ubiquitin binding proteasome binding Supporting Evidence: PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:20471946 hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding PMID:24811749 Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade ubiquitin-conjugated proteins
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:27107012 Pooled-matrix protein interaction screens using Barcode Fusi...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:28514442 Architecture of the human interactome defines protein commun...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:31064842 Phosphorylation of Tyr-950 in the proteasome scaffolding pro...	MODIFY	Summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit interactions, but those should be represented with more specific terms. Reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is too broad for curation. Proposed replacements: ubiquitin binding proteasome binding Supporting Evidence: PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:20471946 hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding PMID:24811749 Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade ubiquitin-conjugated proteins
GO:0005515 protein binding	IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0005515 protein binding	IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func...	MARK AS OVER ANNOTATED	Summary: This generic protein-binding annotation comes from interaction evidence, but generic protein binding is uninformative for ADRM1. Reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator. Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions. Supporting Evidence: PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37 PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0000502 proteasome complex	NAS PMID:29636472 Structural mechanism for nucleotide-driven remodeling of the...	ACCEPT	Summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly recovered in proteasome structural and biochemical studies. Reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex PMID:29636472 Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors Rpn10 and Rpn13, the base subunits within the holoenzyme PMID:33729481 Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin tag on the substrate
GO:0000502 proteasome complex	NAS PMID:33729481 Proteasome in action: substrate degradation by the 26S prote...	ACCEPT	Summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly recovered in proteasome structural and biochemical studies. Reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex PMID:29636472 Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors Rpn10 and Rpn13, the base subunits within the holoenzyme PMID:33729481 Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin tag on the substrate
GO:0000502 proteasome complex	NAS PMID:37228199 An abundance of free regulatory (19S) proteasome particles r...	ACCEPT	Summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly recovered in proteasome structural and biochemical studies. Reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex PMID:29636472 Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors Rpn10 and Rpn13, the base subunits within the holoenzyme PMID:33729481 Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin tag on the substrate
GO:0005829 cytosol	NAS PMID:12032076 Properties of the hybrid form of the 26S proteasome containi...	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0006979 response to oxidative stress	NAS PMID:35858375 Structural insights into the human PA28-20S proteasome enabl...	MARK AS OVER ANNOTATED	Summary: The cited PA28-20S structural work does not provide ADRM1-specific oxidative-stress function. Reason: Mark as over-annotated. Proteasome capacity and ADRM1/Rpn13 autoubiquitination can respond to proteotoxic stress, but the GOA-cited PA28-20S paper does not make ADRM1 a direct response-to-oxidative-stress gene product. Supporting Evidence: PMID:24811749 Rpn13 becomes extensively and selectively poly-ubiquitinated by the proteasome-associated ubiquitin ligase, Ube3c/Hul5 PMID:24811749 Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade ubiquitin-conjugated proteins
GO:0008021 synaptic vesicle	NAS PMID:37228199 An abundance of free regulatory (19S) proteasome particles r...	MARK AS OVER ANNOTATED	Summary: The cited work supports free 19S regulatory particles near synapses, but not ADRM1 as a synaptic-vesicle component. Reason: Mark as over-annotated. A 19S regulatory-particle pool at synapses is relevant proteasome biology, but synaptic vesicle is too specific for ADRM1 without direct ADRM1-resolved localization evidence. Supporting Evidence: PMID:37228199 unexpected abundance of free 19S particles near synapses
GO:0010498 proteasomal protein catabolic process	NAS PMID:33729481 Proteasome in action: substrate degradation by the 26S prote...	ACCEPT	Summary: ADRM1 contributes to proteasomal protein catabolism by recognizing ubiquitinated substrates as Rpn13 and supporting proteasome-associated UCHL5 activity. Reason: Accept as a direct proteostasis process at an appropriate broad level. ADRM1 is not the protease catalytic subunit, but its ubiquitin-receptor and UCHL5-regulatory roles are part of proteasomal substrate processing. Supporting Evidence: PMID:17139257 Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates and decreases the degradation of short-lived proteins PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:20471946 When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated cyclin B was strongly stimulated PMID:33729481 Proteasomes are also vital for maintaining intracellular protein quality control by removing misfolded or aggregate-prone damaged proteins
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process	NAS PMID:19489727 Recognition and processing of ubiquitin-protein conjugates b...	ACCEPT	Summary: ADRM1/Rpn13 functions in ubiquitin-dependent proteasomal degradation by binding ubiquitin signals and supporting 26S proteasome substrate processing. Reason: Accept as a core biological process. Multiple primary studies and reviews support ADRM1 as a 26S proteasome ubiquitin receptor required for efficient degradation of ubiquitin conjugates. Supporting Evidence: PMID:17139257 Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates and decreases the degradation of short-lived proteins PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:20471946 When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated cyclin B was strongly stimulated PMID:33729481 Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin tag on the substrate
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process	NAS PMID:33729481 Proteasome in action: substrate degradation by the 26S prote...	ACCEPT	Summary: ADRM1/Rpn13 functions in ubiquitin-dependent proteasomal degradation by binding ubiquitin signals and supporting 26S proteasome substrate processing. Reason: Accept as a core biological process. Multiple primary studies and reviews support ADRM1 as a 26S proteasome ubiquitin receptor required for efficient degradation of ubiquitin conjugates. Supporting Evidence: PMID:17139257 Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates and decreases the degradation of short-lived proteins PMID:18497817 Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain PMID:20471946 When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated cyclin B was strongly stimulated PMID:33729481 Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin tag on the substrate
GO:0061136 regulation of proteasomal protein catabolic process	NAS PMID:12032076 Properties of the hybrid form of the 26S proteasome containi...	ACCEPT	Summary: ADRM1 regulates proteasomal protein catabolism through substrate-recognition and UCHL5-recruitment mechanisms. Reason: Accept. The term is broad, but it fits ADRM1/Rpn13 as a ubiquitin receptor and UCHL5 recruiter whose loss or modification changes degradation of ubiquitin conjugates. Supporting Evidence: PMID:17139257 Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates and decreases the degradation of short-lived proteins PMID:20471946 When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated cyclin B was strongly stimulated PMID:24811749 Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade ubiquitin-conjugated proteins
GO:0071357 cellular response to type I interferon	NAS PMID:31380390 Regulation of Proteasome Activity by (Post-)transcriptional ...	MARK AS OVER ANNOTATED	Summary: The cited review discusses proteasome regulation in broad cellular contexts and does not establish ADRM1 as a direct type-I-interferon response effector. Reason: Mark as over-annotated. Type-I-interferon biology can regulate proteasome composition/activity, but ADRM1 should not receive a gene-level cellular response to type I interferon annotation from this broad proteasome-regulation review. Supporting Evidence: PMID:31380390 altered transcription of proteasomal subunits and activators
GO:0005654 nucleoplasm	IDA GO_REF:0000052	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	IDA GO_REF:0000052	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005634 nucleus	EXP PMID:16990800 A novel proteasome interacting protein recruits the deubiqui...	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005737 cytoplasm	EXP PMID:16990800 A novel proteasome interacting protein recruits the deubiqui...	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-174058	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-187574	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-188191	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-5635854	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-68825	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-69600	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-8939801	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-8952408	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-9762096	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005654 nucleoplasm	TAS Reactome:R-NUL-9604648	ACCEPT	Summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution. Reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed degradation events in nuclear pathways rather than independent ADRM1 pathway functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-1168640	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-1234159	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-1236970	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-1504193	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-174105	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-174202	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-174203	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-174255	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-180573	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-180603	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-209061	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-2130282	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-264458	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-353125	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-3640874	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-450466	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-4608855	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-4641256	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-4641260	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5362448	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5387392	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5607724	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5607731	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5610754	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5610758	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5610760	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5635868	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5658430	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5665854	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5665871	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5668481	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5668520	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5687112	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-5689539	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-68948	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-69016	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-75825	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8850992	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8852354	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8854044	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8854071	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8866553	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8866858	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8932355	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8956140	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8956184	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-8957265	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9755303	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9755306	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9766223	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-983150	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9907980	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9908026	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9908178	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9929352	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9929486	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9931314	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9934893	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-HSA-9954728	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-NUL-212917	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-NUL-5610751	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0005829 cytosol	TAS Reactome:R-NUL-9011324	ACCEPT	Summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm. Reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement of the proteasome catalyst in substrate-degradation events; they should not be read as separate substrate-specific ADRM1 functions. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:33729481 The 26S proteasome is the major proteasome species in eukaryotes, responsible for proteolysis in the cytoplasm, in the nucleus
GO:0140678 molecular function inhibitor activity	EXP PMID:20471946 Structure of proteasome ubiquitin receptor hRpn13 and its ac...	MARK AS OVER ANNOTATED	Summary: The evidence describes intramolecular/autoregulatory inhibition of free hRpn13 ubiquitin-receptor activity by its C-terminal domain, not ADRM1 acting primarily as a standalone inhibitor. Reason: Mark as over-annotated. The autoinhibitory structural state is real, but the core function of ADRM1 is proteasomal ubiquitin receptor/deubiquitinase regulator; proteasome docking activates ubiquitin binding, so a broad inhibitor-activity annotation overstates the gene product role. Supporting Evidence: PMID:20471946 hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding PMID:20471946 hRpn13's Uch37-binding domain can inhibit its activity as a ubiquitin receptor
GO:0000502 proteasome complex	IDA PMID:17323924 Mass spectrometric characterization of the affinity-purified...	ACCEPT	Summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly recovered in proteasome structural and biochemical studies. Reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex PMID:29636472 Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors Rpn10 and Rpn13, the base subunits within the holoenzyme PMID:33729481 Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin tag on the substrate
GO:0061133 endopeptidase activator activity	IDA PMID:16990800 A novel proteasome interacting protein recruits the deubiqui...	MODIFY	Summary: ADRM1 activates the proteasome-associated deubiquitinase UCHL5/UCH37, so the current endopeptidase activator term is too generic and mechanistically imprecise. Reason: Modify to deubiquitinase activator activity. The cited evidence is about recruiting/activating UCH37/UCHL5 deubiquitinating activity at 26S proteasomes, not a broad endopeptidase activator role. Proposed replacements: deubiquitinase activator activity Supporting Evidence: PMID:16990800 hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes PMID:16990800 loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity
GO:0002020 protease binding	IPI PMID:18922472 Distinct modes of regulation of the Uch37 deubiquitinating e...	MODIFY	Summary: The original protease-binding row is specifically UCHL5/UCH37 binding and should use the more informative ubiquitin-specific protease binding term. Reason: Modify to ubiquitin-specific protease binding. UCHL5/UCH37 is a proteasome-associated deubiquitinating enzyme, and ADRM1 binds/recruits it through the C-terminal DEUBAD region. Proposed replacements: ubiquitin-specific protease binding Supporting Evidence: PMID:16990800 hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes PMID:17139257 The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity PMID:18922472 The conserved DUB Uch37 is found on proteasomes PMID:20471946 Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37
GO:0070628 proteasome binding	IDA PMID:18162577 Relative structural and functional roles of multiple deubiqu...	ACCEPT	Summary: ADRM1 binds/incorporates into the 26S proteasome regulatory particle through its Rpn13/Rpn2-associated receptor role. Reason: Accept as a direct molecular function. ADRM1 is a proteasome-associated ubiquitin receptor and interacts with the proteasome scaffolding protein Rpn2/PSMD1; this is also consistent with the PN regulatory-particle projection. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex PMID:20471946 hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding
GO:0000502 proteasome complex	IDA PMID:16990800 A novel proteasome interacting protein recruits the deubiqui...	ACCEPT	Summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly recovered in proteasome structural and biochemical studies. Reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex PMID:29636472 Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors Rpn10 and Rpn13, the base subunits within the holoenzyme PMID:33729481 Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin tag on the substrate
GO:0006368 transcription elongation by RNA polymerase II	IMP PMID:11818576 Human Elongator facilitates RNA polymerase II transcription ...	UNDECIDED	Summary: The cached abstract for the cited Elongator paper does not connect ADRM1 to RNA polymerase II transcription elongation, but this is an IMP (experimental) annotation whose full text is not available. Reason: This is an experimental (IMP) annotation citing PMID:11818576, which is abstract-only in our cache (full_text_available:false), so the supporting evidence cannot be verified. Per project guidelines, unverifiable experimental annotations should be UNDECIDED rather than REMOVE. Biologically the annotation is implausible - ADRM1/Rpn13 is a 26S proteasome ubiquitin receptor and is not a subunit of the human Elongator complex (ELP1-6); its supported role is proteasomal ubiquitin recognition and UCHL5/UCH37 regulation. Flagged for a curator with full-text access to confirm mis-attribution before removal. Supporting Evidence: PMID:11818576 human Elongator facilitates transcription by RNA polymerase II
GO:0043248 proteasome assembly	IDA PMID:16990800 A novel proteasome interacting protein recruits the deubiqui...	MARK AS OVER ANNOTATED	Summary: ADRM1 is recruited to 26S proteasomes and recruits UCHL5, but the cited evidence does not clearly show a proteasome assembly process role. Reason: Mark as over-annotated. The evidence supports proteasome binding/base-subcomplex membership and UCHL5 recruitment. It does not show ADRM1 catalyzing or directing proteasome assembly as a core biological process. Supporting Evidence: PMID:16990800 we describe the identification of Adrm1 as a novel proteasome interacting protein in mammalian cells PMID:16990800 hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes PMID:17139257 we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex

📄 View Raw YAML

id: Q16186
gene_symbol: ADRM1
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: ADRM1 encodes the human proteasomal ubiquitin receptor Rpn13, a 19S regulatory-particle subunit/cofactor
  of the 26S proteasome. Its N-terminal Pru domain binds ubiquitin signals and the Rpn2/PSMD1 proteasome
  scaffold, while its C-terminal DEUBAD region binds the UCHL5/UCH37 deubiquitinase. Through these interactions
  ADRM1 helps recruit ubiquitinated substrates and coordinate deubiquitinase activity during proteasome-mediated
  protein degradation in cytosolic and nuclear proteostasis.
existing_annotations:
- term:
    id: GO:0008541
    label: proteasome regulatory particle, lid subcomplex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: part_of
  review:
    summary: The evidence supports ADRM1/Rpn13 as a 19S regulatory-particle ubiquitin receptor, but the
      lid-subcomplex placement is less accurate for ADRM1 than the base-subcomplex placement used by the
      PN projection.
    action: MODIFY
    reason: Modify to proteasome regulatory particle, base subcomplex. Primary and structural literature
      describe Rpn13/ADRM1 as a 19S regulatory-particle subunit and as one of the base ubiquitin receptors;
      this supports the PN base-subcomplex projection and argues against retaining the lid-subcomplex
      term for ADRM1.
    proposed_replacement_terms:
    - id: GO:0008540
      label: proteasome regulatory particle, base subcomplex
    - id: GO:0005838
      label: proteasome regulatory particle
    additional_reference_ids:
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
    - reference_id: file:human/ADRM1/ADRM1-deep-research-manual.md
      supporting_text: The Proteostasis PN projection is conservative for ADRM1; proteasome complex
        and regulatory-particle terms are safe, and literature supports modifying the lid-subcomplex
        annotation to the base subcomplex.
- term:
    id: GO:0061133
    label: endopeptidase activator activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: enables
  review:
    summary: ADRM1 activates the proteasome-associated deubiquitinase UCHL5/UCH37, so the current endopeptidase
      activator term is too generic and mechanistically imprecise.
    action: MODIFY
    reason: Modify to deubiquitinase activator activity. The cited evidence is about recruiting/activating
      UCH37/UCHL5 deubiquitinating activity at 26S proteasomes, not a broad endopeptidase activator role.
    proposed_replacement_terms:
    - id: GO:0035800
      label: deubiquitinase activator activity
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:16990800
      supporting_text: loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0070628
    label: proteasome binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: enables
  review:
    summary: ADRM1 binds/incorporates into the 26S proteasome regulatory particle through its Rpn13/Rpn2-associated
      receptor role.
    action: ACCEPT
    reason: Accept as a direct molecular function. ADRM1 is a proteasome-associated ubiquitin receptor
      and interacts with the proteasome scaffolding protein Rpn2/PSMD1; this is also consistent with the
      PN regulatory-particle projection.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16713569
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16990800
  qualifier: enables
  review:
    summary: This protein-binding evidence is real but should be represented by more specific proteasome
      binding and UCHL5/UCH37 binding terms.
    action: MODIFY
    reason: Modify away from generic protein binding. The original evidence supports ADRM1 association
      with proteasome subunits and the UCHL5/UCH37 deubiquitinase, which are better captured by proteasome
      binding and ubiquitin-specific protease binding/deubiquitinase-regulator annotations.
    proposed_replacement_terms:
    - id: GO:0070628
      label: proteasome binding
    - id: GO:1990381
      label: ubiquitin-specific protease binding
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17139257
  qualifier: enables
  review:
    summary: This protein-binding evidence is real but should be represented by more specific proteasome
      binding and UCHL5/UCH37 binding terms.
    action: MODIFY
    reason: Modify away from generic protein binding. The original evidence supports ADRM1 association
      with proteasome subunits and the UCHL5/UCH37 deubiquitinase, which are better captured by proteasome
      binding and ubiquitin-specific protease binding/deubiquitinase-regulator annotations.
    proposed_replacement_terms:
    - id: GO:0070628
      label: proteasome binding
    - id: GO:1990381
      label: ubiquitin-specific protease binding
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18497817
  qualifier: enables
  review:
    summary: This protein-binding row captures direct ubiquitin/UBL-substrate receptor evidence and should
      be replaced by ubiquitin binding.
    action: MODIFY
    reason: Modify to ubiquitin binding. Husnjak et al. identify Rpn13/ADRM1 as a proteasomal ubiquitin
      receptor and map ubiquitin binding to the Pru domain; generic protein binding hides the informative
      molecular function.
    proposed_replacement_terms:
    - id: GO:0043130
      label: ubiquitin binding
    additional_reference_ids:
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: Rpn13 functions as a ubiquitin receptor for the proteasome
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18922472
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19490896
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19615732
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20059542
  qualifier: enables
  review:
    summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit
      interactions, but those should be represented with more specific terms.
    action: MODIFY
    reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly
      recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is
      too broad for curation.
    proposed_replacement_terms:
    - id: GO:0043130
      label: ubiquitin binding
    - id: GO:0070628
      label: proteasome binding
    additional_reference_ids:
    - PMID:18497817
    - PMID:20471946
    - PMID:24811749
    supported_by:
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21516116
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24811749
  qualifier: enables
  review:
    summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit
      interactions, but those should be represented with more specific terms.
    action: MODIFY
    reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly
      recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is
      too broad for curation.
    proposed_replacement_terms:
    - id: GO:0043130
      label: ubiquitin binding
    - id: GO:0070628
      label: proteasome binding
    additional_reference_ids:
    - PMID:18497817
    - PMID:20471946
    - PMID:24811749
    supported_by:
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25416956
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107012
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28514442
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31064842
  qualifier: enables
  review:
    summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit
      interactions, but those should be represented with more specific terms.
    action: MODIFY
    reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly
      recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is
      too broad for curation.
    proposed_replacement_terms:
    - id: GO:0043130
      label: ubiquitin binding
    - id: GO:0070628
      label: proteasome binding
    additional_reference_ids:
    - PMID:18497817
    - PMID:20471946
    - PMID:24811749
    supported_by:
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31515488
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:40205054
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: NAS
  original_reference_id: PMID:29636472
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: NAS
  original_reference_id: PMID:33729481
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: NAS
  original_reference_id: PMID:37228199
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: NAS
  original_reference_id: PMID:12032076
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0006979
    label: response to oxidative stress
  evidence_type: NAS
  original_reference_id: PMID:35858375
  qualifier: involved_in
  review:
    summary: The cited PA28-20S structural work does not provide ADRM1-specific oxidative-stress function.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. Proteasome capacity and ADRM1/Rpn13 autoubiquitination can respond
      to proteotoxic stress, but the GOA-cited PA28-20S paper does not make ADRM1 a direct response-to-oxidative-stress
      gene product.
    additional_reference_ids:
    - PMID:24811749
    supported_by:
    - reference_id: PMID:24811749
      supporting_text: Rpn13 becomes extensively and selectively poly-ubiquitinated by the proteasome-associated
        ubiquitin ligase, Ube3c/Hul5
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0008021
    label: synaptic vesicle
  evidence_type: NAS
  original_reference_id: PMID:37228199
  qualifier: located_in
  review:
    summary: The cited work supports free 19S regulatory particles near synapses, but not ADRM1 as a synaptic-vesicle
      component.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. A 19S regulatory-particle pool at synapses is relevant proteasome
      biology, but synaptic vesicle is too specific for ADRM1 without direct ADRM1-resolved localization
      evidence.
    additional_reference_ids:
    - PMID:37228199
    supported_by:
    - reference_id: PMID:37228199
      supporting_text: unexpected abundance of free 19S particles near synapses
- term:
    id: GO:0010498
    label: proteasomal protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:33729481
  qualifier: involved_in
  review:
    summary: ADRM1 contributes to proteasomal protein catabolism by recognizing ubiquitinated substrates
      as Rpn13 and supporting proteasome-associated UCHL5 activity.
    action: ACCEPT
    reason: Accept as a direct proteostasis process at an appropriate broad level. ADRM1 is not the protease
      catalytic subunit, but its ubiquitin-receptor and UCHL5-regulatory roles are part of proteasomal
      substrate processing.
    additional_reference_ids:
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    - PMID:33729481
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates
        and decreases the degradation of short-lived proteins
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated
        cyclin B was strongly stimulated
    - reference_id: PMID:33729481
      supporting_text: Proteasomes are also vital for maintaining intracellular protein quality control
        by removing misfolded or aggregate-prone damaged proteins
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:19489727
  qualifier: involved_in
  review:
    summary: ADRM1/Rpn13 functions in ubiquitin-dependent proteasomal degradation by binding ubiquitin
      signals and supporting 26S proteasome substrate processing.
    action: ACCEPT
    reason: Accept as a core biological process. Multiple primary studies and reviews support ADRM1 as
      a 26S proteasome ubiquitin receptor required for efficient degradation of ubiquitin conjugates.
    additional_reference_ids:
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    - PMID:33729481
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates
        and decreases the degradation of short-lived proteins
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated
        cyclin B was strongly stimulated
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:33729481
  qualifier: involved_in
  review:
    summary: ADRM1/Rpn13 functions in ubiquitin-dependent proteasomal degradation by binding ubiquitin
      signals and supporting 26S proteasome substrate processing.
    action: ACCEPT
    reason: Accept as a core biological process. Multiple primary studies and reviews support ADRM1 as
      a 26S proteasome ubiquitin receptor required for efficient degradation of ubiquitin conjugates.
    additional_reference_ids:
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    - PMID:33729481
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates
        and decreases the degradation of short-lived proteins
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated
        cyclin B was strongly stimulated
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0061136
    label: regulation of proteasomal protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:12032076
  qualifier: involved_in
  review:
    summary: ADRM1 regulates proteasomal protein catabolism through substrate-recognition and UCHL5-recruitment
      mechanisms.
    action: ACCEPT
    reason: Accept. The term is broad, but it fits ADRM1/Rpn13 as a ubiquitin receptor and UCHL5 recruiter
      whose loss or modification changes degradation of ubiquitin conjugates.
    additional_reference_ids:
    - PMID:17139257
    - PMID:20471946
    - PMID:24811749
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates
        and decreases the degradation of short-lived proteins
    - reference_id: PMID:20471946
      supporting_text: When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated
        cyclin B was strongly stimulated
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0071357
    label: cellular response to type I interferon
  evidence_type: NAS
  original_reference_id: PMID:31380390
  qualifier: involved_in
  review:
    summary: The cited review discusses proteasome regulation in broad cellular contexts and does not
      establish ADRM1 as a direct type-I-interferon response effector.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. Type-I-interferon biology can regulate proteasome composition/activity,
      but ADRM1 should not receive a gene-level cellular response to type I interferon annotation from
      this broad proteasome-regulation review.
    additional_reference_ids:
    - PMID:31380390
    supported_by:
    - reference_id: PMID:31380390
      supporting_text: altered transcription of proteasomal subunits and activators
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: EXP
  original_reference_id: PMID:16990800
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: EXP
  original_reference_id: PMID:16990800
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174058
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-187574
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-188191
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5635854
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-68825
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-69600
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8939801
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8952408
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9762096
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9604648
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1168640
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234159
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1236970
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1504193
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174105
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174202
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174203
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174255
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-180573
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-180603
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-209061
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2130282
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-264458
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-353125
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3640874
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-450466
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4608855
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4641256
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4641260
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5362448
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5387392
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5607724
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5607731
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5610754
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5610758
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5610760
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5635868
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5658430
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5665854
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5665871
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5668481
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5668520
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5687112
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5689539
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-68948
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-69016
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-75825
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8850992
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8852354
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8854044
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8854071
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8866553
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8866858
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8932355
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956140
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956184
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8957265
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9755303
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9755306
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9766223
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-983150
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9907980
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9908026
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9908178
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929352
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929486
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9931314
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9934893
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9954728
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-212917
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-5610751
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9011324
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0140678
    label: molecular function inhibitor activity
  evidence_type: EXP
  original_reference_id: PMID:20471946
  qualifier: enables
  review:
    summary: The evidence describes intramolecular/autoregulatory inhibition of free hRpn13 ubiquitin-receptor
      activity by its C-terminal domain, not ADRM1 acting primarily as a standalone inhibitor.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. The autoinhibitory structural state is real, but the core function
      of ADRM1 is proteasomal ubiquitin receptor/deubiquitinase regulator; proteasome docking activates
      ubiquitin binding, so a broad inhibitor-activity annotation overstates the gene product role.
    additional_reference_ids:
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
    - reference_id: PMID:20471946
      supporting_text: hRpn13's Uch37-binding domain can inhibit its activity as a ubiquitin receptor
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: IDA
  original_reference_id: PMID:17323924
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0061133
    label: endopeptidase activator activity
  evidence_type: IDA
  original_reference_id: PMID:16990800
  qualifier: enables
  review:
    summary: ADRM1 activates the proteasome-associated deubiquitinase UCHL5/UCH37, so the current endopeptidase
      activator term is too generic and mechanistically imprecise.
    action: MODIFY
    reason: Modify to deubiquitinase activator activity. The cited evidence is about recruiting/activating
      UCH37/UCHL5 deubiquitinating activity at 26S proteasomes, not a broad endopeptidase activator role.
    proposed_replacement_terms:
    - id: GO:0035800
      label: deubiquitinase activator activity
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:16990800
      supporting_text: loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0002020
    label: protease binding
  evidence_type: IPI
  original_reference_id: PMID:18922472
  qualifier: enables
  review:
    summary: The original protease-binding row is specifically UCHL5/UCH37 binding and should use the
      more informative ubiquitin-specific protease binding term.
    action: MODIFY
    reason: Modify to ubiquitin-specific protease binding. UCHL5/UCH37 is a proteasome-associated deubiquitinating
      enzyme, and ADRM1 binds/recruits it through the C-terminal DEUBAD region.
    proposed_replacement_terms:
    - id: GO:1990381
      label: ubiquitin-specific protease binding
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18922472
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
    - reference_id: PMID:18922472
      supporting_text: The conserved DUB Uch37 is found on proteasomes
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
- term:
    id: GO:0070628
    label: proteasome binding
  evidence_type: IDA
  original_reference_id: PMID:18162577
  qualifier: enables
  review:
    summary: ADRM1 binds/incorporates into the 26S proteasome regulatory particle through its Rpn13/Rpn2-associated
      receptor role.
    action: ACCEPT
    reason: Accept as a direct molecular function. ADRM1 is a proteasome-associated ubiquitin receptor
      and interacts with the proteasome scaffolding protein Rpn2/PSMD1; this is also consistent with the
      PN regulatory-particle projection.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: IDA
  original_reference_id: PMID:16990800
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0006368
    label: transcription elongation by RNA polymerase II
  evidence_type: IMP
  original_reference_id: PMID:11818576
  qualifier: involved_in
  review:
    summary: The cached abstract for the cited Elongator paper does not connect ADRM1 to RNA polymerase
      II transcription elongation, but this is an IMP (experimental) annotation whose full text is not available.
    action: UNDECIDED
    reason: This is an experimental (IMP) annotation citing PMID:11818576, which is abstract-only in our cache
      (full_text_available:false), so the supporting evidence cannot be verified. Per project guidelines,
      unverifiable experimental annotations should be UNDECIDED rather than REMOVE. Biologically the annotation
      is implausible - ADRM1/Rpn13 is a 26S proteasome ubiquitin receptor and is not a subunit of the human
      Elongator complex (ELP1-6); its supported role is proteasomal ubiquitin recognition and UCHL5/UCH37
      regulation. Flagged for a curator with full-text access to confirm mis-attribution before removal.
    additional_reference_ids:
    - PMID:11818576
    supported_by:
    - reference_id: PMID:11818576
      supporting_text: human Elongator facilitates transcription by RNA polymerase II
- term:
    id: GO:0043248
    label: proteasome assembly
  evidence_type: IDA
  original_reference_id: PMID:16990800
  qualifier: involved_in
  review:
    summary: ADRM1 is recruited to 26S proteasomes and recruits UCHL5, but the cited evidence does not
      clearly show a proteasome assembly process role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. The evidence supports proteasome binding/base-subcomplex membership
      and UCHL5 recruitment. It does not show ADRM1 catalyzing or directing proteasome assembly as a core
      biological process.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:11818576
  title: Human Elongator facilitates RNA polymerase II transcription through chromatin.
  findings:
  - statement: The paper supports human Elongator in RNA polymerase II transcription through chromatin,
      not an ADRM1/Rpn13 role.
    supporting_text: human Elongator facilitates transcription by RNA polymerase II in a chromatin- and
      acetyl-CoA-dependent manner
    reference_section_type: ABSTRACT
- id: PMID:12032076
  title: Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.
  findings: []
- id: PMID:16713569
  title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell
    degeneration.
  findings: []
- id: PMID:16990800
  title: A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.
  findings:
  - statement: ADRM1/Rpn13 is a mammalian proteasome-interacting protein that recruits UCH37 to 26S
      proteasomes.
    supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    reference_section_type: ABSTRACT
  - statement: ADRM1/Rpn13 depletion reduces proteasome-associated UCH37 and deubiquitinating activity.
    supporting_text: loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes
    reference_section_type: ABSTRACT
- id: PMID:17139257
  title: hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.
  findings:
  - statement: ADRM1/Rpn13 is a 407-residue subunit of the human 19S regulatory complex.
    supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    reference_section_type: ABSTRACT
  - statement: ADRM1/Rpn13 binds UCH37 and enhances its isopeptidase activity.
    supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
      enzyme, UCH37, and enhances its isopeptidase activity
    reference_section_type: ABSTRACT
- id: PMID:17323924
  title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
  findings: []
- id: PMID:18162577
  title: Relative structural and functional roles of multiple deubiquitylating proteins associated with
    mammalian 26S proteasome.
  findings: []
- id: PMID:18497817
  title: Proteasome subunit Rpn13 is a novel ubiquitin receptor.
  findings:
  - statement: ADRM1/Rpn13 is a proteasomal ubiquitin receptor whose Pru domain binds ubiquitin.
    supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
      receptor for ubiquitin (Pru) domain
    reference_section_type: ABSTRACT
- id: PMID:18922472
  title: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the
    Ino80 chromatin-remodeling complex.
  findings: []
- id: PMID:19489727
  title: Recognition and processing of ubiquitin-protein conjugates by the proteasome.
  findings: []
- id: PMID:19490896
  title: Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific
    chaperones.
  findings: []
- id: PMID:19615732
  title: Defining the human deubiquitinating enzyme interaction landscape.
  findings: []
- id: PMID:20059542
  title: Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S
    proteasome-mediated proteolysis.
  findings: []
- id: PMID:20471946
  title: Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein
    hRpn2.
  findings:
  - statement: Human Rpn13 serves as a receptor for both ubiquitin and Uch37.
    supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
      and Uch37
    reference_section_type: ABSTRACT
  - statement: hRpn2/S1 binding activates hRpn13 for ubiquitin binding.
    supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
      interactions, thus activating hRpn13 for ubiquitin binding
    reference_section_type: ABSTRACT
- id: PMID:21516116
  title: Next-generation sequencing to generate interactome datasets.
  findings: []
- id: PMID:24811749
  title: Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
  findings:
  - statement: Rpn13 ubiquitination reduces the proteasome's ability to bind and degrade ubiquitin-conjugated
      proteins.
    supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
      ubiquitin-conjugated proteins
    reference_section_type: ABSTRACT
- id: PMID:25416956
  title: A proteome-scale map of the human interactome network.
  findings: []
- id: PMID:27107012
  title: Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
  findings: []
- id: PMID:28514442
  title: Architecture of the human interactome defines protein communities and disease networks.
  findings: []
- id: PMID:29636472
  title: Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated
    human 26S proteasome.
  findings: []
- id: PMID:31064842
  title: Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction
    with the ubiquitin receptor RPN13.
  findings: []
- id: PMID:31380390
  title: Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms.
  findings: []
- id: PMID:31515488
  title: Extensive disruption of protein interactions by genetic variants across the allele frequency
    spectrum in human populations.
  findings: []
- id: PMID:33729481
  title: 'Proteasome in action: substrate degradation by the 26S proteasome.'
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
  findings: []
- id: PMID:35858375
  title: Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification
    of endogenous proteins.
  findings: []
- id: PMID:37228199
  title: An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses.
  findings: []
- id: PMID:40205054
  title: Multimodal cell maps as a foundation for structural and functional genomics.
  findings: []
- id: Reactome:R-HSA-1168640
  title: Ubiquitinated IkB is degraded
  findings: []
- id: Reactome:R-HSA-1234159
  title: Proteasome proteolyzes ub-HIF-alpha
  findings: []
- id: Reactome:R-HSA-1236970
  title: Proteasomal clevage of exogenous antigen (26S proteasome catalyst)
  findings: []
- id: Reactome:R-HSA-1504193
  title: Ubiquitinated DVL is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-174058
  title: Degradation of multiubiquitinated Cdh1
  findings: []
- id: Reactome:R-HSA-174105
  title: Degradation of multiubiquitinated cell cycle proteins
  findings: []
- id: Reactome:R-HSA-174202
  title: Degradation of multiubiquitinated Securin
  findings: []
- id: Reactome:R-HSA-174203
  title: SCF-mediated degradation of Emi1
  findings: []
- id: Reactome:R-HSA-174255
  title: Degradation multiubiquitinated Cyclin A
  findings: []
- id: Reactome:R-HSA-180573
  title: Degradation of ubiquitinated CD4
  findings: []
- id: Reactome:R-HSA-180603
  title: Proteosome-mediated degradation of APOBEC3G
  findings: []
- id: Reactome:R-HSA-187574
  title: Degradation of ubiquitinated p27/p21 by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-188191
  title: APC/C:Cdh1-mediated degradation of Skp2
  findings: []
- id: Reactome:R-HSA-209061
  title: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
  findings: []
- id: Reactome:R-HSA-2130282
  title: Degradation of ubiquitinated beta catenin by the proteasome
  findings: []
- id: Reactome:R-HSA-264458
  title: Proteasome mediated degradation of COP1
  findings: []
- id: Reactome:R-HSA-353125
  title: 26S proteosome degrades ODC holoenzyme complex
  findings: []
- id: Reactome:R-HSA-3640874
  title: Ub-RibC-AXIN is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-450466
  title: AUF1:mRNA complex is degraded
  findings: []
- id: Reactome:R-HSA-4608855
  title: PRICKLE1 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-4641256
  title: Ubiquitinated AXIN is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-4641260
  title: Ubiquitinated DVL1 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5362448
  title: Hh C-terminal fragments are degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5387392
  title: processing defective Hh variants are degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5607724
  title: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
  findings: []
- id: Reactome:R-HSA-5607731
  title: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
  findings: []
- id: Reactome:R-HSA-5610754
  title: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
  findings: []
- id: Reactome:R-HSA-5610758
  title: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
  findings: []
- id: Reactome:R-HSA-5610760
  title: GLI1 is degraded by the proteasome after ubiquitination by ITCH
  findings: []
- id: Reactome:R-HSA-5635854
  title: GLI2,3 are degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5635868
  title: ub-GLI is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5658430
  title: NF1 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5665854
  title: ADRM1:26S proteaseome binds UCHL5
  findings: []
- id: Reactome:R-HSA-5665871
  title: ADRM1 binds 26S proteasome
  findings: []
- id: Reactome:R-HSA-5668481
  title: Protesomal degradation of K48polyUb-TRAF3
  findings: []
- id: Reactome:R-HSA-5668520
  title: 26Sproteasome degrades K48polyUb-NIK
  findings: []
- id: Reactome:R-HSA-5687112
  title: MAPK6 is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-5689539
  title: ADRM1:26S proteaseome binds USP14
  findings: []
- id: Reactome:R-HSA-68825
  title: Ubiquitinated geminin is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-68948
  title: Ubiquitinated Orc1 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-69016
  title: Ubiquitinated Cdc6 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-69600
  title: Proteolytic degradation of ubiquitinated-Cdc25A
  findings: []
- id: Reactome:R-HSA-75825
  title: Proteasome mediated degradation of Cyclin D1
  findings: []
- id: Reactome:R-HSA-8850992
  title: Proteasome degrades polyubiquitinated PTEN
  findings: []
- id: Reactome:R-HSA-8852354
  title: GTSE1 facilitates proteasome-mediated degradation of TP53
  findings: []
- id: Reactome:R-HSA-8854044
  title: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
  findings: []
- id: Reactome:R-HSA-8854071
  title: Proteasome-mediated degradation of PolyUb-FBXL7
  findings: []
- id: Reactome:R-HSA-8866553
  title: misfolded CFTR is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-8866858
  title: CFTR F508del is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-8932355
  title: 26S proteasome degrades Ub-NFE2L2
  findings: []
- id: Reactome:R-HSA-8939801
  title: 26S proteasome degrades PolyUb-RUNX2
  findings: []
- id: Reactome:R-HSA-8952408
  title: Polyubiquitinated RUNX3 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-8956140
  title: NEDD8 and UBD bind NUB1 and the 26S proteasome
  findings: []
- id: Reactome:R-HSA-8956184
  title: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
  findings: []
- id: Reactome:R-HSA-8957265
  title: 26S proteasome degrades TP73 polyubiquitinated by ITCH
  findings: []
- id: Reactome:R-HSA-9755303
  title: 26S proteasome degrades HIFalpha
  findings: []
- id: Reactome:R-HSA-9755306
  title: ub UBXN7 is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-9762096
  title: Ub,pS335,S338,T NFE2L2 is degraded
  findings: []
- id: Reactome:R-HSA-9766223
  title: Proteasome-dependent degradation of ubiquitinated CDH1
  findings: []
- id: Reactome:R-HSA-983150
  title: Proteasomal cleavage of substrate
  findings: []
- id: Reactome:R-HSA-9907980
  title: Formation of the 19S regulatory particle base precursor
  findings: []
- id: Reactome:R-HSA-9908026
  title: Formation of the 19S regulatory particle precursor
  findings: []
- id: Reactome:R-HSA-9908178
  title: Formation of the 26S proteasome
  findings: []
- id: Reactome:R-HSA-9929352
  title: Ubiquitinated CD274 is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-9929486
  title: SPOP-mediated degradation of CD274 by 26S Proteosome
  findings: []
- id: Reactome:R-HSA-9931314
  title: Proteasomal degradation of polyUb-p-S195-CD274
  findings: []
- id: Reactome:R-HSA-9934893
  title: Proteolysis of K48polyUb-K,p-S-PER1,2,3
  findings: []
- id: Reactome:R-HSA-9954728
  title: The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide
  findings: []
- id: Reactome:R-NUL-212917
  title: Proteasome mediated degradation of PAK-2p34
  findings: []
- id: Reactome:R-NUL-5610751
  title: Gli2is degraded by the proteasome
  findings: []
- id: Reactome:R-NUL-9011324
  title: Proteasome degrades SAX-3 ubiquitinated by EBAX-1
  findings: []
- id: Reactome:R-NUL-9604648
  title: Proteasome degrades ubiquitinated mouse NICD4
  findings: []
- id: file:human/ADRM1/ADRM1-notes.md
  title: ADRM1 PN review notes
  findings: []
- id: file:human/ADRM1/ADRM1-deep-research-manual.md
  title: ADRM1 manual deep research
  findings: []
- id: file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_annotations.tsv
  title: Proteostasis PN projected annotations
  findings: []
core_functions:
- description: Proteasomal ubiquitin receptor activity within the 19S regulatory particle, linking ubiquitin-tagged
    substrates to the 26S proteasome for degradation.
  molecular_function:
    id: GO:0043130
    label: ubiquitin binding
  directly_involved_in:
  - id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  - id: GO:0010498
    label: proteasomal protein catabolic process
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005654
    label: nucleoplasm
  in_complex:
    id: GO:0008540
    label: proteasome regulatory particle, base subcomplex
  supported_by:
  - reference_id: PMID:18497817
    supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
      receptor for ubiquitin (Pru) domain
  - reference_id: PMID:20471946
    supporting_text: Rpn13 functions as a ubiquitin receptor for the proteasome
  - reference_id: PMID:33729481
    supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin
      tag on the substrate
- description: Recruitment and activation of the UCHL5/UCH37 deubiquitinase at the 26S proteasome regulatory
    particle.
  molecular_function:
    id: GO:0035800
    label: deubiquitinase activator activity
  directly_involved_in:
  - id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005654
    label: nucleoplasm
  in_complex:
    id: GO:0008540
    label: proteasome regulatory particle, base subcomplex
  supported_by:
  - reference_id: PMID:16990800
    supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
  - reference_id: PMID:16990800
    supporting_text: loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes
  - reference_id: PMID:17139257
    supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
      enzyme, UCH37, and enhances its isopeptidase activity
- description: Stable association with the 19S regulatory-particle/base proteasome subcomplex through
    Rpn2/PSMD1 and related regulatory-particle contacts.
  molecular_function:
    id: GO:0070628
    label: proteasome binding
  directly_involved_in:
  - id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005654
    label: nucleoplasm
  in_complex:
    id: GO:0008540
    label: proteasome regulatory particle, base subcomplex
  supported_by:
  - reference_id: PMID:16990800
    supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
      in mammalian cells
  - reference_id: PMID:17139257
    supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
  - reference_id: PMID:29636472
    supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
      Rpn10 and Rpn13, the base subunits within the holoenzyme
proposed_new_terms: []
suggested_questions:
- question: Should the current ADRM1/Rpn13 GO annotation to proteasome regulatory particle, lid subcomplex
    be replaced by proteasome regulatory particle, base subcomplex in GOA/PAINT?
  experts:
  - Youdong Mao
  - Michael H. Glickman
  - Keiji Tanaka
- question: Should ADRM1 receive direct ubiquitin binding and deubiquitinase activator activity annotations
    in GOA to replace generic protein binding and endopeptidase activator activity?
  experts:
  - Kylie J. Walters
  - Alfred L. Goldberg
  - Keiji Tanaka
suggested_experiments:
- experiment_type: endogenous proteasome structural proteomics
  hypothesis: Endogenous ADRM1 is a base/regulatory-particle ubiquitin receptor rather than a lid-subcomplex
    subunit.
  description: Map endogenous ADRM1 contacts and cryo-EM density in substrate-engaged human 26S proteasomes,
    comparing wild-type ADRM1 with Pru-domain and DEUBAD-domain mutants for Rpn2, ubiquitin-chain, and
    UCHL5 association.
- experiment_type: catalytic-rescue degradation assay
  hypothesis: ADRM1 supports ubiquitin-dependent substrate degradation through both Pru-domain ubiquitin
    recognition and DEUBAD-dependent UCHL5 activation.
  description: Rescue ADRM1-deficient cells with wild-type, ubiquitin-binding-defective, Rpn2-binding-defective,
    and UCHL5-binding-defective ADRM1 alleles, then quantify degradation of defined K48-ubiquitinated
    substrates and proteasome-associated UCHL5 activity.

Gene Description

Existing Annotations Review

Core Functions

Proteasomal ubiquitin receptor activity within the 19S regulatory particle, linking ubiquitin-tagged substrates to the 26S proteasome for degradation.

Recruitment and activation of the UCHL5/UCH37 deubiquitinase at the 26S proteasome regulatory particle.

Stable association with the 19S regulatory-particle/base proteasome subcomplex through Rpn2/PSMD1 and related regulatory-particle contacts.

References

Suggested Questions for Experts

Suggested Experiments

Deep Research

Manual

ADRM1 manual deep research

Core identity

Primary evidence

PN projection assessment

Curation conclusions

📚 Additional Documentation

Notes

ADRM1 notes

Pn Notes

ADRM1 PN Consistency Notes

Source Files Checked

Deep Research Files

AIGR Review Snapshot

PN Consistency Summary

Full Consistency Review

PN Dossier Context

PN row 1: Ubiquitin Proteasome System | Proteasome and associated proteins | proteasome regulatory particle subunit | base, nonATPase | PRU, DEUBAD

PN row 2: Ubiquitin Proteasome System | Ubiquitin and UBL binding | proteasomal subunits | regulatory particle | idiosyncratic Ub binding / PRU

Projected GO annotations (5)

Note

📄 View Raw YAML