Consistency: Strong. Deep research (Falcon), UniProt, GOA, and review YAML all agree FBXO22 is the SCF/CRL1 substrate receptor (substrates KDM4A/B, methylated TP53, BACH1, nuclear PTEN K221, PD-L1, BAG3, MTOR, NSP5). Review MODIFY of GO:0004842 (TAS transferase) → GO:1990756 exactly matches the PN group target. No contradictions.
PN story / NEW pressure: PN asserts only the generic adaptor role, already captured by the review (core_function MF = GO:1990756, verified real, def. "Usually mediated by F-box…proteins"). The rich substrate biology vastly exceeds GOA but the review correctly declines substrate-specific NEW terms (proposed_new_terms empty). Conclusion: PN adaptor claim ALREADY CAPTURED; substrate detail belongs in core_functions, not new GO.
Mapping strategy: Correct. This gene does not change the node; it is the canonical exemplar of the MODIFY-catalytic-MF→GO:1990756 pattern. GO:1990756 is neither broader nor narrower than the review's chosen core MF — they are identical. Class-level GO:0061630 correctly held as context_only/too_broad.
Evidence alignment: PN cites only "15340381 / rev" (PMID:15340381, an F-box family review; not in this review's reference list). Review is anchored on substrate-specific primary papers (PMID:37979583 MTOR, PMID:39223933 NSP5) plus founding F-box papers (PMID:10531035/10531037) and PMID:34445249. Divergence: PN's single review reference is thinner than and disjoint from the review's evidence base, but both support the same adaptor framing.
Verdict: CONSISTENT — no changes needed. Exemplary application of the F-box adaptor pattern.