VPS37C

UniProt: A5D8V6 · batch: proteostasis-pr-1217 · review status: COMPLETE
PN placement: 1 row, ALP — Autophagosome closure maturation and lysosome fusion → Sealing of autophagophore membrane → ESCRT-I complex component. PN-node mapping: leaf=mapped→GO:0000813; sealing group=mapped→GO:0000045; class=context_only (GO:0016236). Projected: GO:0000045 (more_specific_than_existing_goa), GO:0000813 (already_in_goa_exact).
Consistency: PARTIAL CONTRADICTION (same axis as VPS37B). ESCRT-I membership fully consistent: review ACCEPTs GO:0000813, with gene-specific support (ternary complex with TSG101/VPS28, PMID:15509564) and MVB sorting. Autophagy diverges: review MARK_AS_OVER_ANNOTATED both GO:0016236 macroautophagy rows and even MARK_AS_OVER_ANNOTATED a GO:0090148 membrane-fission row (noting the structural paper tested a VPS37B headpiece, not VPS37C), declining GO:0000045. PN still projects GO:0000045 to VPS37C.
PN story / NEW pressure: Over-reaches for autophagy. PN's group GO:0000045 asserts autophagosome assembly the review finds unsupported for VPS37C (phagophore closure is VPS37A-specific; PMID:21757351 explicitly notes UBAP1 ESCRT-I "contains VPS37A but not VPS37C"). ESCRT-I already captured. No NEW term beyond GO:0000813.
Mapping strategy: Flag. Leaf→GO:0000813 correct (already in GOA). Group→GO:0000045 over-reaches for VPS37C — same shared-node over-reach pattern as TOMM20/HSPA8/RAB7A; GO:0000045 should not propagate to VPS37C without gene-specific evidence.
Evidence alignment: Partial. PN cites only PMID:32424346, which the review uses for general ESCRT-I mechanism but explicitly flags as not VPS37C-specific (VPS37B headpiece). Review adds VPS37C-specific PMID:15509564 and ALG-2 context PMID:23924735, absent from PN. PN omits the UBAP1 caveat (PMID:21757351) the review relies on.
Verdict: Consistent on ESCRT-I; GO:0000045 projection over-reaches. Recommended edits: none to YAML (review correctly omits GO:0000045); flag PN sealing-group→GO:0000045 as non-propagating to VPS37C.