Cilium life-cycle candidate members (generated by scripts/cilium_members.py)
68 candidates; 63 have a gene review; 48 have an HPA call at a cilium, basal body, centrosome or centriolar satellite.
HPA grades: E = Enhanced, S = Supported, A = Approved, U = Uncertain.
| stage | gene | UniProt | role | review | HPA cilia/centrosome calls | HPA main location |
|---|---|---|---|---|---|---|
| 1_basal_body_licensing | CEP83 | Q9Y592 | distal appendage root component | complete | Primary cilium (U); Primary cilium transition zone (U) | Golgi apparatus;Primary cilium;Primary cilium transition zone;Vesicles |
| 1_basal_body_licensing | SCLT1 | Q96NL6 | distal appendage component | complete | Basal body (S) | Basal body;Cytosol |
| 1_basal_body_licensing | CEP89 | Q96ST8 | distal appendage component | complete | Primary cilium (U); Basal body (S); Centrosome (S) | Cytosol |
| 1_basal_body_licensing | FBF1 | Q8TES7 | distal appendage component | complete | Primary cilium (U); Basal body (S); Centrosome (S) | Basal body;Centrosome |
| 1_basal_body_licensing | CEP164 | Q9UPV0 | distal appendage component; TTBK2 recruitment | complete | Primary cilium transition zone (U); Centrosome (S) | Centrosome;Primary cilium transition zone;Principal piece |
| 1_basal_body_licensing | TTBK2 | Q6IQ55 | kinase removing CP110-CEP97 cap | complete | Primary cilium (A); Primary cilium transition zone (A); Basal body (A) | Cytosol;Microtubules |
| 1_basal_body_licensing | CCP110 | O43303 | distal centriole cap (ciliogenesis suppressor) | complete | Centriolar satellite (A) | Centriolar satellite |
| 1_basal_body_licensing | CEP97 | Q8IW35 | distal centriole cap partner | complete | Basal body (A); Centrosome (S); Centriolar satellite (A) | Centriolar satellite;Centrosome;Cytosol |
| 1_basal_body_licensing | KIF24 | Q5T7B8 | MT-depolymerizing kinesin at mother centriole (ciliogenesis suppressor) | complete | - | not in HPA |
| 1_basal_body_licensing | MPHOSPH9 | Q99550 | distal centriole cap recruiter of CP110-CEP97 | none | Basal body (S); Centrosome (S) | Cytosol;Plasma membrane |
| 2_ciliary_vesicle | MYO5A | Q9Y4I1 | preciliary vesicle transport to distal appendages | complete | Primary cilium (A); Basal body (A); Centriolar satellite (A) | Centriolar satellite;Focal adhesion sites |
| 2_ciliary_vesicle | EHD1 | Q9H4M9 | ciliary vesicle formation | complete | Primary cilium (S); Primary cilium transition zone (S) | Plasma membrane |
| 2_ciliary_vesicle | EHD3 | Q9NZN3 | ciliary vesicle formation | complete | Primary cilium (S); Primary cilium transition zone (S) | Plasma membrane |
| 2_ciliary_vesicle | PACSIN1 | Q9BY11 | ciliary vesicle tubulation | none | - | Nucleoplasm;Vesicles |
| 2_ciliary_vesicle | RAB11A | P62491 | Rab cascade upstream GTPase | none | Primary cilium (U); Basal body (U); Centriolar satellite (S) | Centriolar satellite;Vesicles |
| 2_ciliary_vesicle | RAB3IP | Q96QF0 | Rabin8; RAB8 GEF | complete | Centrosome (S) | Nucleoplasm |
| 2_ciliary_vesicle | RAB8A | P61006 | ciliary membrane delivery GTPase | complete | Primary cilium (U); Basal body (U); Centriolar satellite (U) | Nucleoli;Nucleoplasm;Plasma membrane |
| 3_transition_zone | CEP290 | O15078 | transition zone scaffold | complete | Primary cilium (A); Basal body (U); Centrosome (A) | Basal body;Centrosome;Mid piece |
| 3_transition_zone | MKS1 | Q9NXB0 | MKS module | complete | Basal body (S) | Basal body;Nucleoli;Nucleoplasm |
| 3_transition_zone | TMEM67 | Q5HYA8 | MKS module | complete | - | not in HPA |
| 3_transition_zone | CC2D2A | Q9P2K1 | MKS module | complete | - | Connecting piece;Mid piece |
| 3_transition_zone | B9D1 | Q9UPM9 | MKS module | complete | Basal body (S) | Acrosome;Equatorial segment;Mid piece;Nucleoplasm |
| 3_transition_zone | B9D2 | Q9BPU9 | MKS module | complete | Basal body (S); Centrosome (U) | Golgi apparatus;Nucleoli |
| 3_transition_zone | TCTN1 | Q2MV58 | MKS module | complete | Primary cilium (A) | Actin filaments;Primary cilium |
| 3_transition_zone | TCTN2 | Q96GX1 | MKS module | complete | Primary cilium transition zone (A) | Golgi apparatus;Microtubules |
| 3_transition_zone | TMEM216 | Q9P0N5 | MKS module | complete | - | not in HPA |
| 3_transition_zone | TMEM231 | Q9H6L2 | MKS module | complete | - | Vesicles |
| 3_transition_zone | NPHP1 | O15259 | NPHP module | complete | - | not in HPA |
| 3_transition_zone | NPHP4 | O75161 | NPHP module | complete | - | Nucleoplasm |
| 3_transition_zone | RPGRIP1L | Q68CZ1 | NPHP module | complete | Primary cilium (S); Basal body (U) | Cytosol;Plasma membrane |
| 3_transition_zone | AHI1 | Q8N157 | transition zone | complete | Primary cilium (A); Centrosome (S) | Centrosome |
| 4_axoneme_extension_ift | IFT88 | Q13099 | IFT-B core | complete | Primary cilium (S); Basal body (S); Centriolar satellite (A) | End piece;Microtubules;Primary cilium |
| 4_axoneme_extension_ift | IFT52 | Q9Y366 | IFT-B core | complete | Primary cilium (A); Basal body (A) | Microtubules |
| 4_axoneme_extension_ift | IFT81 | Q8WYA0 | IFT-B core; tubulin binding | complete | Primary cilium (A); Basal body (A); Centrosome (A) | Cytosol |
| 4_axoneme_extension_ift | IFT74 | Q96LB3 | IFT-B core; tubulin binding | complete | Basal body (S); Centriolar satellite (S) | Basal body;Centriolar satellite;Golgi apparatus |
| 4_axoneme_extension_ift | IFT172 | Q9UG01 | IFT-B peripheral | complete | - | not in HPA |
| 4_axoneme_extension_ift | IFT140 | Q96RY7 | IFT-A | complete | Basal body (S) | Basal body |
| 4_axoneme_extension_ift | IFT122 | Q9HBG6 | IFT-A | complete | Primary cilium transition zone (S) | Cytosol;Mid piece;Primary cilium transition zone |
| 4_axoneme_extension_ift | WDR35 | Q9P2L0 | IFT-A | complete | - | not in HPA |
| 4_axoneme_extension_ift | TTC21B | Q7Z4L5 | IFT-A | complete | Primary cilium (A); Basal body (A); Centriolar satellite (A) | Basal body;Centriolar satellite;Primary cilium |
| 4_axoneme_extension_ift | KIF3A | Q9Y496 | kinesin-2 motor | complete | Primary cilium (A); Basal body (A) | Basal body;Cytosol;Nucleoplasm;Primary cilium |
| 4_axoneme_extension_ift | KIF3B | O15066 | kinesin-2 motor | complete | Primary cilium tip (A) | Flagellar centriole;Nucleoplasm;Primary cilium tip |
| 4_axoneme_extension_ift | KIFAP3 | Q92845 | kinesin-2 accessory | complete | Basal body (A) | Basal body;Microtubules |
| 4_axoneme_extension_ift | KIF17 | Q9P2E2 | homodimeric kinesin-2 | none | Primary cilium tip (A); Basal body (A) | Nucleoplasm |
| 4_axoneme_extension_ift | DYNC2H1 | Q8NCM8 | dynein-2 heavy chain | complete | - | Mid piece;Mitochondria |
| 4_axoneme_extension_ift | DYNC2LI1 | Q8TCX1 | dynein-2 light intermediate chain | complete | Primary cilium (S); Basal body (S) | Cytosol;Mid piece |
| 4_axoneme_extension_ift | DYNC2I1 | Q8WVS4 | dynein-2 intermediate chain (WDR60) | complete | Primary cilium (S); Basal body (A); Centrosome (S) | Basal body;Centrosome |
| 4_axoneme_extension_ift | DYNC2I2 | Q96EX3 | dynein-2 intermediate chain (WDR34) | complete | Primary cilium (A); Basal body (S); Centrosome (S) | Basal body;Centrosome;Nucleoplasm |
| 5_membrane_composition | ARL13B | Q3SXY8 | ciliary membrane GTPase; ARL3 GEF | complete | Primary cilium (S); Primary cilium transition zone (S); Basal body (U) | Microtubules;Primary cilium;Primary cilium transition zone |
| 5_membrane_composition | ARL3 | P36405 | ciliary cargo release GTPase | complete | Primary cilium (S); Basal body (A); Centrosome (S) | Basal body;Centrosome;Nucleoplasm |
| 5_membrane_composition | INPP5E | Q9NRR6 | ciliary phosphoinositide phosphatase | complete | - | Golgi apparatus |
| 5_membrane_composition | TULP3 | O75386 | IFT-A adaptor for membrane protein entry | complete | Primary cilium (S); Primary cilium transition zone (S); Basal body (U) | Nucleoplasm;Primary cilium |
| 5_membrane_composition | PDE6D | O43924 | lipidated cargo carrier | complete | - | Vesicles |
| 5_membrane_composition | UNC119B | A6NIH7 | myristoylated cargo carrier | complete | - | Annulus;Cytokinetic bridge;Cytosol;Flagellar centriole;Mitotic spindle |
| 5_membrane_composition | RP2 | O75695 | ARL3 GAP | complete | - | End piece;Mid piece;Plasma membrane;Principal piece |
| 5_membrane_composition | BBS1 | Q8NFJ9 | BBSome (see modules/bbsome.yaml) | complete | - | Midbody |
| 5_membrane_composition | LZTFL1 | Q9NQ48 | BBSome regulator | complete | Primary cilium (U); Primary cilium transition zone (U) | Cytosol |
| 6_length_control | CILK1 | Q9UPZ9 | ciliary length kinase (ICK) | complete | Primary cilium (S); Primary cilium tip (S) | Golgi apparatus;Vesicles |
| 6_length_control | MAK | P20794 | ciliary length kinase | complete | Basal body (A) | Basal body;Connecting piece;Cytosol;Nucleoplasm |
| 6_length_control | KIF7 | Q2M1P5 | ciliary tip length regulator | complete | Primary cilium (S); Primary cilium tip (S) | Primary cilium;Primary cilium tip |
| 7_disassembly | AURKA | O14965 | ciliary disassembly kinase | complete | Basal body (S); Centrosome (S) | Basal body;Centrosome;Mitotic spindle |
| 7_disassembly | NEDD9 | Q14511 | AURKA activator (HEF1) | complete | - | Cytosol;Nucleoplasm |
| 7_disassembly | HDAC6 | Q9UBN7 | axonemal tubulin deacetylase | complete | Basal body (S); Centrosome (S) | Basal body;Centrosome;Cytosol |
| 7_disassembly | PLK1 | P53350 | disassembly kinase | complete | - | not in HPA |
| 7_disassembly | KIF2A | O00139 | MT depolymerase at basal body | complete | Basal body (U); Centrosome (E) | Annulus;Basal body;Centrosome;Nucleoli;Nucleoplasm |
| 7_disassembly | CIMAP3 | Q8TCI5 | Pitchfork (CIMAP3); AURKA activator | complete | - | not in HPA |
| 7_disassembly | DYNLT1 | P63172 | Tctex-1; resorption | complete | - | Acrosome;Cytosol |
| 7_disassembly | OFD1 | O75665 | centriolar satellite/distal centriole; autophagy link | none | Primary cilium (U) | Microtubules |