Human microprotein census (auto-generated)

Human microprotein census (auto-generated)

Swiss-Prot human entries <= 100 aa: 776; unreviewed reference-proteome entries <= 100 aa (non-fragment): 8918.

GO coverage by class (Swiss-Prot <= 100 aa)

class n any GO informative GO experimental MF BP only protein binding
other characterized small protein 249 90.8% 85.9% 63.1% 53.4% 72.3% 4.8%
secreted peptide / hormone / defensin 168 98.8% 98.8% 54.2% 60.1% 76.2% 0.0%
sORF-class microprotein, putative (no protein-level evidence) 125 34.4% 26.4% 4.0% 5.6% 9.6% 8.0%
sORF-class microprotein, protein-level evidence 69 79.7% 76.8% 53.6% 23.2% 43.5% 2.9%
OXPHOS subunit 45 100.0% 100.0% 97.8% 64.4% 95.6% 0.0%
keratin-associated / cornified envelope 44 90.9% 88.6% 29.5% 22.7% 38.6% 2.3%
Ig/TCR gene segment 25 96.0% 96.0% 0.0% 0.0% 0.0% 0.0%
mtDNA-rRNA-encoded peptide (humanin-like) 21 81.0% 81.0% 19.0% 71.4% 66.7% 0.0%
ribosomal protein 16 100.0% 100.0% 87.5% 100.0% 100.0% 0.0%
metallothionein 14 100.0% 100.0% 71.4% 100.0% 100.0% 0.0%

GO coverage by length (all Swiss-Prot human)

length n any GO informative GO experimental MF BP
1-50 99 74.7% 73.7% 19.2% 32.3% 35.4%
51-100 677 84.5% 80.9% 52.6% 45.6% 61.9%
101-150 1503 89.4% 85.1% 51.4% 53.2% 70.1%
151-300 4236 94.9% 92.6% 70.6% 71.6% 79.1%
301-600 7859 97.9% 96.9% 74.2% 86.5% 89.7%
>600 6057 98.7% 97.9% 80.5% 86.0% 91.5%

sORF-class microproteins with protein-level evidence

symbol (UniProt gene) acc aa informative GO exp IBA IEA experimental GO terms name
AQP5-AS1 A0A7L8Y648 51 2 2 0 0 actin filament organization [GO:0007015, IMP]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058, IMP] Micropeptide inhibiting actin cytoskeleton
ASDURF L0R819 96 4 2 0 1 cytoplasm [GO:0005737, EXP]; RPAP3/R2TP/prefoldin-like complex [GO:1990062, IPI] ASNSD1 upstream open reading frame protein
BRD3OS A0A1B0GUI7 84 0 0 0 0 - Uncharacterized protein BRD3OS
C0HM83 58 4 2 0 2 nucleus [GO:0005634, IDA]; mitochondrion [GO:0005739, IDA] Protein SHMOOSE
C10orf53 Q8N6V4 93 0 0 0 0 - UPF0728 protein C10orf53
C18orf32 Q8TCD1 76 6 4 0 2 endoplasmic reticulum [GO:0005783, EXP]; endoplasmic reticulum [GO:0005783, IDA]; lipid droplet [GO:0005811, IDA]; positive regulation of canonical NF-kappaB signal transduction [GO:0043123, HMP] UPF0729 protein C18orf32
C19orf53 Q9UNZ5 99 0 0 0 0 - Leydig cell tumor 10 kDa protein homolog
C20orf202 A1L168 99 0 0 0 0 - Uncharacterized protein C20orf202
C2orf15 Q8WU43 91 1 1 0 0 RNA binding [GO:0003723, HDA] Uncharacterized protein C2orf15
C8orf17 Q9NRJ1 99 6 2 0 2 nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA] Protein MOST-1
CCDC179 H3BU77 68 0 0 0 0 - Coiled-coil domain-containing protein 179
CEBPZOS A8MTT3 80 3 2 0 1 mitochondrion [GO:0005739, HTP]; mitochondrial membrane [GO:0031966, EXP] Protein CEBPZOS
CHD9NB A0A1B0GV96 52 0 0 0 0 - CHD9 neighbor protein
CLMB Q96GX8 76 4 3 0 1 plasma membrane [GO:0005886, IDA]; membrane [GO:0016020, IDA]; adaptive thermogenesis [GO:1990845, IDA] Calcimembrin
DDIT3 P0DPQ6 34 4 2 0 2 nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA] DDIT3 upstream open reading frame protein
ERLN P0DI80 62 2 0 0 1 - Endoregulin
FAM240C A0A1B0GVR7 95 0 0 0 0 - Protein FAM240C
FBXW7-AS1 B0L3A2 85 8 7 0 1 endothelin receptor activity [GO:0004962, IDA]; plasma membrane [GO:0005886, IDA]; vascular endothelial growth factor signaling pathway [GO:0038084, IDA]; vascular endothelial growth factor binding [GO:0038085, IDA]; endothelin receptor signaling pathway [GO:0086100, IDA] Dual endothelin-1/VEGF signal peptide receptor
HOXB-AS3 C0HLZ6 53 3 3 0 0 regulation of RNA splicing [GO:0043484, IMP]; protein stabilization [GO:0050821, IMP]; negative regulation of pre-miRNA processing [GO:2000632, IDA] HOXB-AS3 peptide
HRURF P0DUH7 34 0 0 0 0 - Protein HRURF
KIAA0040 Q15053 99 1 0 0 1 - Uncharacterized protein KIAA0040
LINC-PINT A0A455ZAR2 87 3 2 0 1 negative regulation of transcription by RNA polymerase II [GO:0000122, IMP]; nucleus [GO:0005634, IDA] Transcriptional regulator PINT87aa
LINC01587 Q99440 93 1 0 0 0 - Uncharacterized protein encoded by LINC01587
MARCHF6-DT P0DW81 44 9 7 0 2 chromosome [GO:0005694, EXP]; nucleolus [GO:0005730, IDA]; regulation of protein ADP-ribosylation [GO:0010835, IDA]; negative regulation of protein ubiquitination [GO:0031397, IDA]; positive regulation of DNA repair [GO:0045739, IDA]; poly-ADP-D-ribose binding [GO:0072572, IDA]; site of DNA damage [GO:0090734, IDA] Poly-ADP-ribosylation-amplifying and CtIP-maintaining microp
MICOS10 Q5TGZ0 78 18 9 1 3 SAM complex [GO:0001401, HDA]; mitochondrion [GO:0005739, HDA]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial inner membrane [GO:0005743, EXP]; cristae formation [GO:0042407, IMP]; MICOS complex [GO:0061617, HDA]; MIB complex [GO:0140275, HDA] MICOS complex subunit MIC10
MIEF1 L0R8F8 70 14 13 0 1 mitochondrial fission [GO:0000266, IMP]; mitochondrion [GO:0005739, HTP]; mitochondrion [GO:0005739, IDA]; mitochondrial matrix [GO:0005759, EXP]; mitochondrial matrix [GO:0005759, IDA]; mitochondrial respiratory chain complex I assembly [GO:0032981, IMP]; positive regulation of mitochondrial translation [GO:0070131, IDA]; mitochondrial large ribosomal subunit binding [GO:0140978, IDA]; mitochondrial large ribosomal subunit assembly [GO:1902775, IDA]; mitochondrial large ribosomal subunit assembly [GO:1902775, IMP] Mitochondrial ribosome and complex I assembly factor AltMIEF
MIR155HG C0HMA1 17 6 4 0 2 negative regulation of dendritic cell antigen processing and presentation [GO:0002605, IDA]; nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; Hsp70 protein binding [GO:0030544, IPI] HSPA8-interacting micropeptide miPEP155
MLDHR C0HLV8 31 4 3 0 1 mitochondrion [GO:0005739, IDA]; negative regulation of oxidative phosphorylation [GO:0090324, IMP]; L-lactate dehydrogenase inhibitor activity [GO:0160193, IDA] PTEN upstream open reading frame MP31
MMP24OS A0A0U1RRL7 71 0 0 0 0 - Protein MMP24OS
MRLN P0DMT0 46 8 0 0 4 - Myoregulin
MTLN Q8NCU8 56 22 4 2 8 mitochondrion [GO:0005739, IDA]; fatty acid beta-oxidation [GO:0006635, IMP]; triglyceride homeostasis [GO:0070328, IMP]; mitochondrial respirasome assembly [GO:0097250, IDA] Mitoregulin
MYMX A0A1B0GTQ4 84 24 2 6 10 myoblast fusion [GO:0007520, IGI]; myoblast fusion involved in skeletal muscle regeneration [GO:0014905, IMP] Protein myomixer
MYOCOS A0A1B0GUC4 80 0 0 0 0 - Myocilin opposite strand protein
NBDY A0A0U1RRE5 68 4 3 0 1 P-body [GO:0000932, IDA]; nuclear-transcribed mRNA catabolic process [GO:0000956, IDA]; negative regulation of cytoplasmic mRNA processing body assembly [GO:0010607, IDA] Negative regulator of P-body association
P3R3URF A0A087WWA1 95 1 0 1 0 - PIK3R3 upstream open reading frame protein
PIGBOS1 A0A0B4J2F0 54 5 3 0 2 mitochondrion [GO:0005739, HTP]; mitochondrial outer membrane [GO:0005741, IDA]; regulation of endoplasmic reticulum unfolded protein response [GO:1900101, IMP] Protein PIGBOS1
PRKCH C0HM02 26 10 10 0 0 negative regulation of translation [GO:0017148, IDA]; negative regulation of translation [GO:0017148, IMP]; protein serine/threonine kinase inhibitor activity [GO:0030291, IDA]; positive regulation of translation in response to stress [GO:0032056, IDA]; cellular response to amino acid starvation [GO:0034198, IDA]; translation regulator activity [GO:0045182, IDA]; protein serine/threonine kinase binding [GO:0120283, IPI] PRKCH upstream open reading frame 2
SCYGR1 A0A286YEY9 88 0 0 0 0 - Small cysteine and glycine repeat-containing protein 1
SCYGR3 A0A286YF60 100 0 0 0 0 - Small cysteine and glycine repeat-containing protein 3
SCYGR5 A0A286YF46 85 0 0 0 0 - Small cysteine and glycine repeat-containing protein 5
SCYGR7 A0A286YF01 96 0 0 0 0 - Small cysteine and glycine repeat-containing protein 7
SCYGR9 P0DSO2 92 0 0 0 0 - Small cysteine and glycine repeat-containing protein 9
SMIM1 B2RUZ4 78 10 6 3 1 plasma membrane [GO:0005886, IDA]; plasma membrane [GO:0005886, IMP]; cell surface [GO:0009986, IDA]; cell surface [GO:0009986, IMP]; protein homodimerization activity [GO:0042803, IDA] Small integral membrane protein 1
SMIM10 Q96HG1 83 1 0 0 1 - Small integral membrane protein 10
SMIM10L1 P0DMW3 68 1 1 0 0 mitochondrion [GO:0005739, HTP] Small integral membrane protein 10-like protein 1
SMIM11 P58511 58 1 0 0 1 - Small integral membrane protein 11
SMIM12 Q96EX1 92 2 1 0 1 mitochondrion [GO:0005739, HTP] Small integral membrane protein 12
SMIM13 P0DJ93 91 1 0 0 1 - Small integral membrane protein 13
SMIM14 Q96QK8 99 3 1 1 1 endoplasmic reticulum [GO:0005783, IDA] Small integral membrane protein 14
SMIM15 Q7Z3B0 74 1 0 0 1 - Small integral membrane protein 15
SMIM18 P0DKX4 95 1 0 0 1 - Small integral membrane protein 18
SMIM2 Q9BVW6 85 1 0 0 1 - Small integral membrane protein 2
SMIM22 K7EJ46 83 8 5 1 2 positive regulation of cell migration [GO:0030335, IMP]; regulation of actin cytoskeleton organization [GO:0032956, IMP]; regulation of cell population proliferation [GO:0042127, IMP]; regulation of cell cycle [GO:0051726, IMP]; lipid droplet formation [GO:0140042, IMP] Small integral membrane protein 22
SMIM26 A0A096LP01 95 7 5 1 1 mitochondrion [GO:0005739, IDA]; mitochondrial outer membrane [GO:0005741, EXP]; mitochondrial outer membrane [GO:0005741, IDA]; protein kinase binding [GO:0019901, IPI]; transmembrane transporter binding [GO:0044325, IPI] Small integral membrane protein 26
SMIM3 Q9BZL3 60 2 1 0 1 identical protein binding [GO:0042802, IPI] Small integral membrane protein 3
SMIM36 A0A1B0GVT2 93 1 0 0 1 - Small integral membrane protein 36
SMIM40 Q5STR5 79 1 0 0 1 - Small integral membrane protein 40
SMIM41 A0A2R8YCJ5 93 1 0 0 1 - Small integral membrane protein 41
SMIM43 Q4W5P6 63 10 2 0 5 transmembrane transporter binding [GO:0044325, IPI] Small integral membrane protein 43
SMIM5 Q71RC9 77 1 0 0 1 - Small integral membrane protein 5
SMIM8 Q96KF7 97 2 1 0 1 mitochondrion [GO:0005739, HTP] Small integral membrane protein 8
SNURF Q9Y675 71 7 1 1 4 nuclear speck [GO:0016607, IDA] SNRPN upstream reading frame protein
SPAAR A0A1B0GVQ0 90 11 5 0 5 lysosomal membrane [GO:0005765, IDA]; late endosome membrane [GO:0031902, IDA]; lysosomal proton-transporting V-type ATPase complex [GO:0046611, IDA]; cellular response to amino acid stimulus [GO:0071230, IMP]; negative regulation of TORC1 signaling [GO:1904262, IMP] Small regulatory polypeptide of amino acid response
STRIT1 P0DN84 35 8 0 0 2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator
TEX53 A0A1B0GU33 70 0 0 0 0 - Testis-expressed protein 53
TINCR A0A2R8Y7D0 87 9 3 0 3 nucleus [GO:0005634, EXP]; positive regulation of keratinocyte proliferation [GO:0010838, IMP]; anchoring junction [GO:0070161, EXP] Ubiquitin domain-containing protein TINCR
TUNAR A0A1B0GTB2 48 11 5 0 1 endoplasmic reticulum [GO:0005783, IDA]; endoplasmic reticulum membrane [GO:0005789, EXP]; endoplasmic reticulum calcium ion homeostasis [GO:0032469, IDA]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774, IDA]; ATPase binding [GO:0051117, IPI] Protein TUNAR
TZMP1 A0A1B0GUW7 55 3 2 0 1 ciliary transition zone [GO:0035869, IMP]; cilium assembly [GO:0060271, IMP] Transition zone microprotein 1
ZNF689 C0HLU2 46 6 4 0 2 nucleus [GO:0005634, IDA]; cytoplasm [GO:0005737, IDA]; regulation of transcription by RNA polymerase II [GO:0006357, IDA]; histone binding [GO:0042393, IDA] Transcriptional regulator SEHBP